Multifunctional “Janus‐Type” Bilayer Films Combine Broad‐Range Tissue Adhesion with Guided Drug Release

Abstract Tissue healing is a challenging process that requires the successful and simultaneous management of conflicting priorities. While promoting wound closure, a battle must be won against different external factors that may adversely affect the healing process. Here this problem is approached by creating asymmetrically designed double‐layer Janus‐type bilayer films where distinct functions are implemented into the two sides of the film. Once deployed, those Janus‐type films exhibit strong adhesion to a wide variety of wet tissues and canalize the release of integrated therapeutics toward the tissue side. At the same time, the outer surface of the films acts as a shield against tribological stress, pathogens, and cellular immune recognition. Moreover, when compared to untreated wounds, Janus‐treated skin lesions show accelerated wound closure as well as fast formation of new, intact tissue. Having performed their tasks, Janus‐type films degrade without leaving any traces on the tissues, which makes it possible to apply them to sensitive body surfaces. Thus, it is expected that the Janus‐type bilayer films designed here can be used in a variety of medical applications where conflicting demands must be met at the same time.