Evaluation of resorbable barrier for preventing surgical adhesions

Abstract The barrier material of Fe 3+ cross-linked pure carboxy-methylcellulose (CMC) has been evaluated in the prevention of postoperative adhesion formation in the injured Achilles tendon using rabbit model. Adhesion formation between the wounds has been assessed and quantitated 14 days after the surgery of 30 rabbits, each of which had two test sites. The use of a Fe 3+ cross-linked carboxy-methylcellulose (CMC) barrier material has effectively reduced the postoperative adhesion formation with 88% fewer adhesions observed in these models without any adverse impact on the tissues, which implies great potential in preventing the postoperative adhesions and deserves clinical evaluation.