DataVXAdvanced Functional MaterialsPaper
journal article·2022-06Open access

Scalable Thousand Channel Penetrating Microneedle Arrays on Flex for Multimodal and Large Area Coverage BrainMachine Interfaces

Sang Heon Lee, Martin Thunemann, Keundong Lee, Daniel R. Cleary, Karen J. Tonsfeldt, Hongseok Oh, Farid Azzazy, Youngbin Tchoe, Andrew M. Bourhis, Lorraine Hossain, Yun Goo Ro, Atsunori Tanaka, Kıvılcım Kılıç, Anna Devor, Shadi A. Dayeh

Advanced Functional Materials· Volume 32· Issue 25
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Source abstract

Abstract

Abstract The Utah array powers cutting‐edge projects for restoration of neurological function, such as BrainGate, but the underlying electrode technology has itself advanced little in the last three decades. Here, advanced dual‐side lithographic microfabrication processes is exploited to demonstrate a 1024‐channel penetrating silicon microneedle array (SiMNA) that is scalable in its recording capabilities and cortical coverage and is suitable for clinical translation. The SiMNA is the first penetrating microneedle array with a flexible backing that affords compliancy to brain movements. In addition, the SiMNA is optically transparent permitting simultaneous optical and electrophysiological interrogation of neuronal activity. The SiMNA is used to demonstrate reliable recordings of spontaneous and evoked field potentials and of single unit activity in chronically implanted mice for up to 196 days in response to optogenetic and to whisker air‐puff stimuli. Significantly, the 1024‐channel SiMNA establishes detailed spatiotemporal mapping of broadband brain activity in rats. This novel scalable and biocompatible SiMNA with its multimodal capability and sensitivity to broadband brain activity will accelerate the progress in fundamental neurophysiological investigations and establishes a new milestone for penetrating and large area coverage microelectrode arrays for brain–machine interfaces.
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Research context

Biomaterials

OpenAlex topics: Neuroscience and Neural Engineering · EEG and Brain-Computer Interfaces · Neural dynamics and brain function

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Integrated Electronics and Biointerfaces Laboratory Department of Electrical and Computer Engineering University of California San Diego CA 92093 USA

Biomedical Engineering Department Boston University Boston MA 02215 USA

Department of Neurological Surgery University of California San Diego La Jolla CA 92093 USA

Department of Obstetrics, Gynecology, and Reproductive Sciences Center for Reproductive Science and Medicine University of California San Diego La Jolla CA 92093 USA

Graduate Program of Materials Science and Engineering University of California San Diego La Jolla CA 92093 USA

Athinoula A. Martinos Center for Biomedical Imaging Department of Radiology Harvard Medical School Massachusetts General Hospital Charlestown MA 02129 USA

Funding

National Institutes of Health · National Science Foundation · American University of Beirut · Division of Civil, Mechanical and Manufacturing Innovation · Division of Electrical, Communications and Cyber Systems · National Institute of Neurological Disorders and Stroke · National Institute on Drug Abuse · National Institute of Mental Health · National Institute of Biomedical Imaging and Bioengineering

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