Molecular Self-Assembly of an Unusual Dinuclear Ruthenium(III) Complex Based on the Nucleobase Guanine
Source abstract
Abstract
The study of crystal structures based on complexes containing purine nucleobases is a significant research subject, mainly regarding the diagnosis and treatment of some diseases and the investigation of genetic mutations and biochemical structures in life sciences. We have obtained and characterized a new dinuclear ruthenium(III) complex based on guanine with the formula [{Ru(µ-Cl)(µ-gua)}2Cl4]·2H2O (1) (gua = guanine). 1 was characterized by means of Fourier transform infrared spectroscopy (FT–IR), scanning electron microscopy and energy dispersive X-ray analysis (SEM–EDX), single-crystal X-ray diffraction (XRD), Hirshfeld surface analysis and cyclic voltammetry (CV). The study of its electrochemical properties allowed us to investigate the presence of guanine molecules when linked to the ruthenium(III) ion in 1. The well-resolved voltammetric response together with the reliability and stability achieved through 1 could provide a step forward to developing new ruthenium-based platforms, devices and modified electrodes adequate to study this purine nucleobase.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Metal complexes synthesis and properties · DNA and Nucleic Acid Chemistry · RNA and protein synthesis mechanisms
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Instituto de Ciencia Molecular (ICMol), Universitat de València, c/Catedrático José Beltrán 2, Paterna, 46980 València, Spain
Funding
Ministry of Science and Innovation · VLC-BIOCLINIC
References (42)
Show source-provided references
1. Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells10.1126/science.1152241 ↗
2. A New View into the Regulation of Purine Metabolism—The Purinosome10.1016/j.tibs.2016.09.009 ↗
3. G-quadruplexes and their regulatory roles in biology10.1093/nar/gkv862 ↗
4. Alzheimer’s Disease: Biomarkers in the Genome, Blood, and Cerebrospinal Fluid10.3389/fneur.2017.00102 ↗
5. Elevated blood purine levels as a biomarker of seizures and epilepsy10.1111/epi.16839 ↗
6. Protein carbonyl content: A novel biomarker for aging in HIV/AIDS patients10.1016/j.bjid.2016.09.007 ↗
7. Nucleic acid oxidation is associated with biomarkers of neurodegeneration in CSF in people with HIV10.1212/NXI.0000000000000902 ↗
8. Determination of purines and pyrimidines in beer samples by capillary zone electrophoresis10.1016/S0003-2670(01)01570-7 ↗
9. Determination and profiling of purines in foods by using HPLC and LC-MS10.1080/15257770.2013.865744 ↗
10. Regarding ruthenium10.1038/nchem.917 ↗
11. Allylic ruthenium(IV) complexes in catalysis10.1016/j.ccr.2011.10.018 ↗
12. Thiolato-bridged dinuclear arene ruthenium complexes and their potential as anticancer drugs10.1016/j.ccr.2015.10.007 ↗
13. The development of anticancer ruthenium(II) complexes: From single molecule compounds to nanomaterials10.1039/C7CS00195A ↗
14. Alessio, E. (2017). Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective. Eur. J. Inorg. Chem., 1549–1560.10.1002/ejic.201600986 ↗
15. Alessio, E., and Messori, L. (2019). NAMI-A and KP1019/1339, Two Iconic Ruthenium Anticancer Drug Candidates Face-to-Face: A Case Story in Medicinal Inorganic Chemistry. Molecules, 24.10.3390/molecules24101995 ↗
16. Organometallic Ruthenium(II) Diamine Anticancer Complexes: Arene-Nucleobase Stacking and Stereospecific Hydrogen-Bonding in Guanine Adducts10.1021/ja017482e ↗
17. Hexachlororhenate(IV) salts of ruthenium(III) cations: X-ray structure and magnetic properties10.1016/j.ica.2011.09.010 ↗
18. Molecular Self-Assembly in a Family of Oxo-Bridged Dinuclear Ruthenium(IV) Systems10.1021/acs.cgd.9b01702 ↗
19. Synthesis, Crystal Structure, Magnetic Properties, and Theoretical Studies of [{Cu(mepirizole)Br}2(μ-OH)(μ-pz)] (Mepirizole = 4-Methoxy-2-(5-methoxy-3-methyl-1H-pyrazol-1-yl)-6-methylpyrimidine; pz = Pyrazolate), a Novel μ-Pyrazolato−μ-Hydroxo-Dibridged Copper(II) Complex10.1021/ic034126j ↗
20. Self-Assembly of a Chiral Carbonate- and Cytidine-Containing Dodecanuclear Copper(II) Complex: A Multiarm-Supplied Globular Capsule10.1021/ic801815s ↗
21. Cubane-Type CuII4 and MnII2MnIII2 Complexes Based on Pyridoxine: A Versatile Ligand for Metal Assembling10.1021/ic4016355 ↗
22. Enhancement of Intermolecular Magnetic Exchange through Halogen···Halogen Interactions in Bisadeninium Rhenium(IV) Salts10.1021/acs.cgd.7b00841 ↗
23. Field-induced slow relaxation of magnetisation in two one-dimensional homometallic dysprosium(III) complexes based on alpha- and beta-amino acids10.1039/D0DT01126F ↗
24. Orts-Arroyo, M., Ten-Esteve, A., Ginés-Cárdenas, S., Castro, I., Martí-Bonmatí, L., and Martínez-Lillo, J. (2021). A gadolinium(III) complex based on the thymine nucleobase with properties suitable for magnetic resonance imaging. Int. J. Mol. Sci., 22.10.20944/preprints202103.0662.v1 ↗
25. Orts-Arroyo, M., Castro, I., and Martínez-Lillo, J. (2021). Detection of Hypoxanthine from Inosine and Unusual Hydrolysis of Immunosuppressive Drug Azathioprine through the Formation of a Diruthenium(III) System. Biosensors, 11.10.3390/bios11010019 ↗
26. Hexahalorhenate(IV) salts of protonated ciprofloxacin: Antibiotic-based single-ion magnets10.1039/D1CE01337H ↗
27. Orts-Arroyo, M., Sanchis-Perucho, A., Moliner, N., Castro, I., Lloret, F., and Martínez-Lillo, J. (2022). One-Dimensional Gadolinium (III) Complexes Based on Alpha- and Beta-Amino Acids Exhibiting Field-Induced Slow Relaxation of Magnetization. Inorganics, 10.10.3390/inorganics10030032 ↗
28. Solution, solid state and biological characterization of ruthenium(III)-DMSO complexes with purine base derivatives10.1016/j.jinorgbio.2003.12.001 ↗
29. (2017). SHELXTL-2017/1, Bruker Analytical X-ray Instruments, Bruker.
30. (2018). DIAMOND 4.5.0, Crystal Impact GbR., Crystal Impact.
31. IR spectra of guanine and hypoxanthine isolated molecules10.1016/0022-2860(87)80024-8 ↗
32. IR Spectra of Crystalline Nucleobases: Combination of Periodic Harmonic Calculations with Anharmonic Corrections Based on Finite Models10.1021/acs.jpcb.9b06285 ↗
33. Hirshfeld surface analysis10.1039/B818330A ↗
34. Turner, M.J., McKinnon, J.J., Wolff, S.K., Grimwood, D.J., Spackman, P.R., Jayatilaka, D., and Spackman, M.A. (2017). Crystal Explorer 17, University of Western Australia.
35. Synthesis and characterization of Ru(III) complexes with 2-((E)-((4-((4-bromophenyl)ethynyl)phenyl)imino)methyl-4-((E)-phenyldiazenyl)phenol and their use as a precursor for RuO2 nanoparticles10.1016/j.molstruc.2018.08.085 ↗
36. Sur, V.P., Mazumdar, A., Kopel, P., Mukherjee, S., Vítek, P., Michalkova, H., Vaculovičová, M., and Moulick, A. (2020). A Novel Ruthenium Based Coordination Compound Against Pathogenic Bacteria. Int. J. Mol. Sci., 21.10.3390/ijms21072656 ↗
37. Magnetic and electrochemical properties of transition metal complexes with multiple metal-to-metal bonds. II. Tetrabutyratodiruthenium(n+) with n = 0 and 110.1021/ic50144a035 ↗
38. Electrochemical studies of a novel ruthenium(II,III) dimer, trifluoroacetamidatoruthenium chloride (Ru2(HNOCCF3)4Cl)10.1021/ic00164a012 ↗
39. An unprecedented up-field shift in the 13C NMR spectrum of the carboxyl carbons of the lantern-type dinuclear complex TBA[Ru2(O2CCH3)4Cl2] (TBA+ = tetra(n-butyl)ammonium cation)10.1039/C5DT01680K ↗
40. A neutral paddlewheel-type diruthenium(III) complex with benzamidinato ligands: Synthesis, crystal structure, magnetism, and electrochemical and absorption properties10.1016/j.poly.2017.03.005 ↗
41. Simultaneous detection of guanine, adenine, thymine, and cytosine at polyaniline/MnO2 modified electrode10.1016/j.electacta.2013.10.064 ↗
42. Electrochemical detection of adenine and guanine using a three-dimensional WS2 nanosheet/graphite microfiber hybrid electrode10.1016/j.elecom.2019.01.007 ↗