journal article·2023-12Open access

Dual‐Active Center AgFeCu Nanocatalyst for Tumor Destruction via Self‐Catalytically Enhanced Mild Photothermal Therapy

Xuegang Niu, Yang Zhu, Chenyu Ding, Jing Ma, Penghui Wei, Yuanxiang Lin, Wenhua Fang, Qiu He, Chunwang Li, Junjie Cheng, Jianhua Zou, Lisen Lin, Xiaoyuan Chen, Dezhi Kang

Advanced Functional Materials· Volume 33· Issue 51

Abstract

Abstract Mild photothermal therapy (mPTT) has emerged as a highly promising approach for tumor ablation. However, the heat‐induced overexpression of heat shock proteins (HSPs) limits its efficacy by increasing cellular temperature tolerance. Herein, a self‐catalytically enhanced mild PTT strategy that directly disrupts the structure of HSPs to restore tumor cell sensitivity is proposed. In the proof‐of‐concept study, AgFeCu nanoparticles (AgFeCu NPs) with dual‐active catalytic centers (Fe‐Cu) and near‐infrared photothermal properties are developed. The AgFeCu NPs can efficiently catalyze the conversion of endogenous hydrogen peroxide into hydroxyl radicals in situ, leading to the degradation of HSPs and enhancing the therapeutic effects of mild PTT mediated by their Ag‐based substrates. Furthermore, AgFeCu NPs can also induce oxidative stress by depleting intracellular glutathione and promoting lipid peroxidation, thereby triggering tumor ferroptosis and resulting in significant tumor elimination in a U87MG murine tumor model. This self‐catalytically enhanced strategy maximizes the efficacy of mild PTT while minimizing damage to healthy tissues, which is expected to provide valuable insights for the development of next‐generation photothermal nanoagents for improved tumor therapeutics.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Endoplasmic Reticulum Stress and Disease · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neurosurgery Neurosurgery Research Institute the First Affiliated Hospital of Fujian Medical University Fuzhou 350005 China

Department of Neurosurgery National Regional Medical Center Binhai Campus of the First Affiliated Hospital of Fujian Medical University Fuzhou 350209 China

Fujian Provincial Institutes of Brain Disorders and Brain Sciences the First Affiliated Hospital of Fujian Medical University Fuzhou 350005 China

MOE Key Laboratory for Analytical Science of Food Safety and Biology College of Chemistry Fuzhou University Fuzhou 350108 China

Department of Chemistry University of Science and Technology of China Hefei 230026 China

Departments of Diagnostic Radiology Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore

Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore

Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Institute of Molecular and Cell Biology Agency for Science, Technology, and Research (A*STAR) 61 Biopolis Drive, Proteos Singapore 138673 Singapore

Funding

National Natural Science Foundation of China · National Medical Research Council

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