Advanced Materials in Wireless, Implantable Electrical Stimulators that Offer Rapid Rates of Bioresorption for Peripheral Axon Regeneration

Hexia Guo; Dom D'Andrea; Jie Zhao; Yue Xu; Zheng Qiao; Lindsay E. Janes; Nikhil K. Murthy; Rui Li; Zhaoqian Xie; Zhen Song; Rohan Meda; Jahyun Koo; Wubin Bai; Yeon Sik Choi; Sumanas W. Jordan; Yonggang Huang; Colin K. Franz; John A. Rogers

doi:10.1002/adfm.202102724

journal article·2021-07Open access

Advanced Materials in Wireless, Implantable Electrical Stimulators that Offer Rapid Rates of Bioresorption for Peripheral Axon Regeneration

Hexia Guo, Dom D'Andrea, Jie Zhao, Yue Xu, Zheng Qiao, Lindsay E. Janes, Nikhil K. Murthy, Rui Li, Zhaoqian Xie, Zhen Song, Rohan Meda, Jahyun Koo, Wubin Bai, Yeon Sik Choi, Sumanas W. Jordan, Yonggang Huang, Colin K. Franz, John A. Rogers

Advanced Functional Materials· Volume 31· Issue 29

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Source abstract

Abstract

Abstract Injured peripheral nerves typically exhibit unsatisfactory and incomplete functional outcomes, and there are no clinically approved therapies for improving regeneration. Post‐operative electrical stimulation (ES) increases axon regrowth, but practical challenges, from the cost of extended operating room time to the risks and pitfalls associated with transcutaneous wire placement, have prevented broad clinical adoption. This study presents a possible solution in the form of advanced bioresorbable materials for a type of thin, flexible, wireless implant that provides precisely controlled ES of the injured nerve for a brief time in the immediate post‐operative period. Afterward, rapid, complete, and safe modes of bioresorption naturally and quickly eliminate all of the constituent materials in their entirety, without the need for surgical extraction. The unusually high rate of bioresorption follows from the use of a unique, bilayer enclosure that combines two distinct formulations of a biocompatible form of polyanhydride as an encapsulating structure, to accelerate the resorption of active components and confine fragments until complete resorption. Results from mouse models of tibial nerve transection with re‐anastomosis indicate that this system offers levels of performance and efficacy that match those of conventional wired stimulators, but without the need to extend the operative period or to extract the device hardware.

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Research context

Biomaterials

OpenAlex topics: Nerve injury and regeneration · Electrospun Nanofibers in Biomedical Applications · Neuroscience and Neural Engineering

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Materials Science and Engineering Querrey Simpson Institute for Bioelectronics Northwestern University Evanston IL 60208 USA

Laboratory of Regenerative Rehabilitation Shirley Ryan AbilityLab Chicago IL 60611 USA

Department of Materials Science Fudan University Shanghai 200433 China

Department of Biomedical Engineering Northwestern University Evanston IL 60208 USA

Department of Materials Science and Engineering Northwestern University Evanston IL 60208 USA

Division of Plastic and Reconstructive Surgery Department of Surgery Simpson Querrey Institute Northwestern University Chicago IL 60611 USA

Laboratory of Regenerative Rehabilitation Shirley Ryan AbilityLab Department of Neurological Surgery Northwestern University Chicago IL 60611 USA

State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering Mechanics International Research Center for Computational Mechanics Dalian University of Technology Dalian 116024 China

School of Biomedical Engineering Interdisciplinary Program in precision Public Health Korea University Seoul 02841 Republic of Korea

Department of Civil and Environmental Engineering Mechanical Engineering Materials Science and Engineering Center for Bio‐integrated Electronics Querrey Simpson Institute for Bioelectronics Northwestern University Evanston IL 60208 USA

Laboratory of Regenerative Rehabilitation Shirley Ryan AbilityLab Department of Physical Medicine and Rehabilitation The Ken and Ruth Davee Department of Neurology Northwestern University Feinberg School of Medicine Chicago IL 60611 USA

Department of Materials Science and Engineering Biomedical Engineering Neurological Surgery Chemistry Mechanical Engineering Electrical and Computer Engineering Center for Bio‐integrated Electronics Querrey Simpson Institute for Bioelectronics Northwestern University Evanston IL 60208 USA

Funding

National Science Foundation · National Natural Science Foundation of China · Liaoning Revitalization Talents Program · Fundamental Research Funds for the Central Universities

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