DataVXAdvanced Functional MaterialsPaper
journal article·2024-10Open access

Highly Conjugated Nanozyme with Non Coordination Saturation for Cascaded Enhanced POD Reaction Driving Antibacterial Therapy

Mutian Yang, Youxing Liu, Ludan Zhang, Yuping Qian, Ningyu Li, Guanmeng Zhang, Yuxiang Hu, Xin Li, Yanjun Ge, Yang Peng, Jinna Ren, Yong Jiang, Shaojun Guo, Yuguang Wang

Advanced Functional Materials· Volume 34· Issue 42
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Source abstract

Abstract

Abstract The misuse of antibiotics leads to emergence of drug‐resistant bacteria. Developing artificial nanozymes with high stability and excellent catalytic performance is desirable to substitute for antibiotics, but still remains huge challenge. Herein, the study reports a new strategy for cascaded enhanced peroxidase (POD) reaction driving antibacterial therapy via constructing 2D conjugated metal‐organic frameworks (MOFs) with non coordination saturation as nanozyme. It is demonstrated that the non coordination saturation Cu atom promotes the adsorption of H 2 O 2 , followed by the Cu‐HHTP MOFs with high conjugated structure can enhance the photogenerated electron transfer for ·OH generation in POD reaction. The sequential enhancement of substrate adsorption and decomposition endows the as‐made Cu‐HHTP MOFs with outstanding antibacterial property of >99.9999% elimination with a concentration only 1/133 that of traditional nanozyme. In addition, the study also certifies its excellent in vivo antimicrobial activity and biocompatibility, indicating the therapeutic potential for infections by drug‐resistant bacteria.
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Research context

NanomaterialsBiomaterialsCatalysis & surfaces

OpenAlex topics: Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of General Dentistry II Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials & Central Laboratory Peking University School and Hospital of Stomatology No.22,...

School of Materials Science and Engineering Peking University Beijing 100871 P. R. China

Changsha Stomatological Hospital Changsha 410000 P. R. China

Department of Prosthodontics Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials Beijing 100081 P. R. China

Funding

National Natural Science Foundation of China · China Postdoctoral Science Foundation

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