(Z)-2-(2-(Anthracen-9-ylmethylene)hydrazineyl)pyrimidine-rhodium(III): Crystal Structure and DNA Binding Property
Source abstract
Abstract
A new rhodium(III) complex of a 9-anthrahydrazone ligand ((Z)-2-(2-(Anthracen-9-ylmethylene)hydrazineyl)pyrimidine, 9-PMAH) is six-coordinated respectively by one bidentate ligand, one solvent DMSO, and three chlorides, to form a distorted octahedral coordination geometry. The ligand chelates to Rh(III) via the hydrazone N atom (N1) and pyrimidine N atom (N3), whereas DMSO coordinates to Rh(III) via the S atom. The three chloride ligands (Cl1, Cl2, and Cl3) are in a mer-configuration of the octahedron, with the DMSO cis- to the pyrimidine nitrogen. In solution, the complex may exist in the positively charged species, [RhIIICl2(DMSO)(9-PMAH)]+, but can be stable in this mode for no less than 48 h. It was suggested by the fluorescence spectroscopic analysis that the complex showed much higher intercalative binding ability with ct-DNA than the typical DNA intercalator, EtBr.
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Research context
OpenAlex topics: Metal complexes synthesis and properties · DNA and Nucleic Acid Chemistry · HIV/AIDS drug development and treatment
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Material Science and Energy Engineering, Foshan University, Foshan 528000, China
School of Chemistry & Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China
Funding
National Natural Science Foundation of China · Key Project of Biomedicine and Health in Colleges and Universities of Guangdong Province · Medical Science and Technology Research Fund of Guangdong Province
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