Self‐Propelled Tags for Protein Detection
Source abstract
Abstract
Abstract Protein detection is of tremendous significance for biological and biomedical sciences. Because there is no equivalent of polymerase chain reaction available as a tool for protein detection, researchers must rely on tags to enhance the limits of detection. One of the crucial steps is the actual labeling of proteins, which relies on diffusion of the label, which is very slow, or external mixing of the label and protein is needed. Here, a conceptually new approach is demonstrated: self‐propelled tags that autonomously move in the solution and enhance protein detection. The tags used here are based on IrO2/Pt bilayer microtubules, which can self‐propel and act as moving tags for enhanced protein electrochemical detection. This completely new label‐based protein detection concept using self‐propelled tag will find a wide spectrum of applications.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Micro and Nano Robotics · Advanced biosensing and bioanalysis techniques · Modular Robots and Swarm Intelligence
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Center for Advanced Functional Nanorobots Department of Inorganic Chemistry University of Chemistry and Technology Prague Technická 5 ,166 28 Prague 6 Czech Republic
Department of Chemical and Biomolecular Engineering Yonsei University 50 Yonsei‐ro, Seodaemun‐gu Seoul 03722 Korea
Department of Medical Research China Medical University Hospital China Medical University No. 91 Hsueh‐Shih Road Taichung 40402 Taiwan
Future Energy and Innovation Laboratory Central European Institute of Technology Brno University of Technology Purkyňova 656/123 Brno CZ‐616 00 Czech Republic
Funding
Grantová Agentura České Republiky
References (56)
Show source-provided references
1. 10.1021/cr300248x10.1021/cr300248x ↗
2. 10.1021/cr500279h10.1021/cr500279h ↗
3. 10.1021/acs.chemrev.6b0022010.1021/acs.chemrev.6b00220 ↗
4. 10.1002/adfm.20160096110.1002/adfm.201600961 ↗
5. 10.1021/acsami.8b0160710.1021/acsami.8b01607 ↗
6. 10.1021/acs.chemrev.7b0003710.1021/acs.chemrev.7b00037 ↗
7. 10.1021/acs.chemrev.5b0010010.1021/acs.chemrev.5b00100 ↗
8. 10.1021/cr300120g10.1021/cr300120g ↗
9. 10.1021/acs.chemrev.5b0026510.1021/acs.chemrev.5b00265 ↗
10. 10.3390/s1807201010.3390/s18072010 ↗
11. 10.1021/cr400273r10.1021/cr400273r ↗
12. 10.1021/acs.chemrev.5b0004710.1021/acs.chemrev.5b00047 ↗
13. 10.1039/C4NR01321B10.1039/C4NR01321B ↗
14. 10.1002/adfm.20160475910.1002/adfm.201604759 ↗
15. 10.1039/C7SC02434G10.1039/C7SC02434G ↗
16. 10.1021/acsnano.5b0280710.1021/acsnano.5b02807 ↗
17. 10.1002/admt.20180050210.1002/admt.201800502 ↗
18. 10.1021/acsami.9b0833210.1021/acsami.9b08332 ↗
19. 10.1002/adfm.20160116510.1002/adfm.201601165 ↗
20. 10.1002/anie.20150197110.1002/anie.201501971 ↗
21. 10.1021/acs.nanolett.5b0314010.1021/acs.nanolett.5b03140 ↗
22. 10.1021/ja107234910.1021/ja1072349 ↗
23. 10.1002/smll.20130306810.1002/smll.201303068 ↗
24. 10.1021/nn301175b10.1021/nn301175b ↗
25. 10.1021/nl203717q10.1021/nl203717q ↗
26. 10.1021/nn305372n10.1021/nn305372n ↗
27. 10.1021/acssensors.5b0030010.1021/acssensors.5b00300 ↗
28. 10.1021/acs.nanolett.5b0194510.1021/acs.nanolett.5b01945 ↗
29. 10.1016/j.apmt.2017.07.01110.1016/j.apmt.2017.07.011 ↗
30. 10.1016/j.apmt.2018.08.00410.1016/j.apmt.2018.08.004 ↗
31. 10.1016/j.apmt.2017.09.00510.1016/j.apmt.2017.09.005 ↗
32. 10.1016/j.apmt.2019.02.00410.1016/j.apmt.2019.02.004 ↗
33. 10.1021/acs.analchem.6b0057410.1021/acs.analchem.6b00574 ↗
34. 10.1038/s41467-018-06727-810.1038/s41467-018-06727-8 ↗
35. 10.1021/acsami.9b0060510.1021/acsami.9b00605 ↗
36. 10.1039/C7NR01168G10.1039/C7NR01168G ↗
37. 10.1002/smll.20110159310.1002/smll.201101593 ↗
38. 10.1039/C2NR32400H10.1039/C2NR32400H ↗
39. 10.1016/j.trac.2016.03.00910.1016/j.trac.2016.03.009 ↗
40. 10.1021/nl203717q10.1021/nl203717q ↗
41. 10.1002/adma.20190182810.1002/adma.201901828 ↗
42. 10.1002/adfm.20150105010.1002/adfm.201501050 ↗
43. 10.1021/acs.analchem.5b0089010.1021/acs.analchem.5b00890 ↗
44. 10.1016/S0956-5663(03)00275-610.1016/S0956-5663(03)00275-6 ↗
45. 10.1002/cjoc.20079023910.1002/cjoc.200790239 ↗
46. 10.1039/C7NJ00756F10.1039/C7NJ00756F ↗
47. 10.1016/0013-4686(94)85168-910.1016/0013-4686(94)85168-9 ↗
48. Kakooei S. · Int. J. Electrochem. Sci. · 2013 · 8 · 329010.1016/S1452-3981(23)14390-2 ↗
49. 10.1002/sia.622510.1002/sia.6225 ↗
50. https://assets.thermofisher.com/TFS‐Assets/LSG/manuals/dynabeads_m280tosylactivated_man.pdf (accessed: September 2019).
51. 10.1021/nn302396910.1021/nn3023969 ↗
52. 10.1016/j.bios.2014.05.06610.1016/j.bios.2014.05.066 ↗
53. 10.1002/smll.20150235010.1002/smll.201502350 ↗
54. 10.1021/nl301726g10.1021/nl301726g ↗
55. 10.1093/ilar.46.3.25810.1093/ilar.46.3.258 ↗
56. 10.1016/j.snb.2008.03.03710.1016/j.snb.2008.03.037 ↗