journal article·2022-11

Biomimetic Aggregation‐Induced Emission Nanodots with Hitchhiking Function for T Cell‐Mediated Cancer Targeting and NIR‐II Fluorescence‐Guided Mild‐Temperature Photothermal Therapy

Xing Yang, Ting Yang, Qiqi Liu, Xiuwen Zhang, Xinghua Yu, Ryan T. K. Kwok, Luo Hai, Pengfei Zhang, Ben Zhong Tang, Lintao Cai, Ping Gong

Advanced Functional Materials· Volume 32· Issue 45
Publisher page

Abstract

Abstract Photothermal therapy (PTT) holds potential as an alternative approach for effective cancer treatment since it exerts minimal side effects on normal tissues. However, the photothermal stimulation increases the expression of heat shock protein (HSP) in tumor cells, rendering the tumor cells insensitive to heat and thus constraining the effects of PTT. In this study, biomimetic aggregation‐induced emission (AIE) photothermal agents with hitchhiking ability (DC@BPBBT dots) are developed by coating the nanoaggregates of the NIR AIE polymeric photothermal agents with dendritic cell (DC) membranes. Notably, the inner nanoaggregate (BPBBT dots) holds bright second‐window near infrared (NIR‐II) fluorescence (quantum yield of up to 3.47%) and a high photothermal conversion performance (photothermal conversion efficiency of up to 30.5%), and the outer cell membrane can facilitate the hitchhiking of DC@BPBBT dots on endogenous T cells and enhance the tumor delivery efficiency by about 1.2 times. Furthermore, DC@BPBBT dots can activate and stimulate T cells in vivo to secrete cytokine tumor necrosis factor α (TNF‐α), which can reduce the expression of heat shock protein 70 (HSP70) to render tumor cells more sensitive to heat. This study not only provides an alternative heat shock protein inhibition strategy based on immune cell interactions but also provides a hitchhike approach for drug delivery in cancer photothermal immunotherapy.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Extracellular vesicles in disease · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangdong Key Laboratory of Nanomedicine Shenzhen engineering Laboratory of nanomedicine and nanoformulations CAS‐HK Joint Lab for Biomaterials CAS Key Lab for Health Informatics Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 P. R. China

University of Chinese Academy of Sciences Beijing 100049 P. R. China

Institute of Basic Medicine and Cancer (IBMC) Chinese Academy of Sciences Hangzhou Zhejiang 310022 P. R. China

Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction Institute for Advanced Study and Division of Life Science The Hong Kong University of Science and Technology Hong Kong 99907 P. R. China

Central Laboratory National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Shenzhen 518116 P. R. China

School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen Guangdong 518172 P. R. China

Funding

Innovation and Technology Commission · National Natural Science Foundation of China · China Postdoctoral Science Foundation

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