Bio‐Micromotor Tweezers for Noninvasive Bio‐Cargo Delivery and Precise Therapy

Abstract Active and targeted bio‐cargo delivery by micromotors holds exciting prospects in biomedical applications. However, such delivery still faces great challenges when implemented in bio‐microenvironments with minimal invasiveness, flexible controllability, and full biocompatibility. Here, a noncontact delivery platform based on bio‐micromotor tweezers is reported, which fulfill these demands by using hydrodynamic forces to exert precision control over bio‐cargos. The concept is based on two optically trapped living microalgae cells with intrinsic motility and biocompatibility: The rotating cells generate highly localized flow fields, which can trap and drive cargos of arbitrary material and shape along controllable trajectories in different biological media in a noncontact manner. The proposed strategy is effective for both biological cells and drugs with minimalized biological damages due to the absence of harmful and cumbersome loading/unloading steps of bio‐cargos on micromotors. Importantly, it is further applied to realize targeted drug delivery into single cancer cell for precise therapy. Such bio‐micromotor tweezers provide great potential for different biomedical applications such as, targeted drug/cell delivery, drug testing, accurate diagnosis, and precise therapy.