Photoresponsive Drug Delivery Systems: Challenges and Progress
Source abstract
Abstract
Abstract Photoresponsive drug delivery systems (PDDSs) have emerged as a promising toolbox for drug delivery, offering precise control over the site, duration, and dosage of light‐triggered medication. It allows controlled drug release, photo‐triggered targeting, diagnosis, and treatment, improving the precision and efficacy of therapies for various diseases. Despite progress in designing different PDDSs, clinical translation has been limited due to various obstacles. Herein, this review article focuses on three critical challenges of PDDSs: 1) accumulation at diseased lesions, 2) precision of light irradiation, and 3) penetration of light in tissues. Also, this article summarizes and discusses current advancements and strategies to address these challenges. Overall, it emphasizes the need to clarify the current challenges from bench to bedside and develop strategies to enhance therapeutic outcomes, increase compatibility and patient compliance, and unlock the possibilities in different clinical therapies.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Gold and Silver Nanoparticles Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Pharmacy Shanghai Pudong Hospital, Fudan University Pudong Medical Center & School of Pharmacy Key Laboratory of Smart Drug Delivery Ministry of Education Fudan University Shanghai 201399 China
Department of Pharmacology School of Basic Medical Sciences & State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University Shanghai 200438 China
State Key Laboratory of Pharmaceutical Biotechnology & Department of Pharmacology and Pharmacy Li Ka Shing Faculty of Medicine & Dr Li Dak‐Sum Research Centre The University of Hong Kong Pokfulam 999077 Hong Kong China
Funding
National Natural Science Foundation of China
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