DataVXAdvanced Functional MaterialsPaper
journal article·2024-04

Strong and Tough Biofibers Designed by Dual Crosslinking for Sutures

Yao Xiao, Ze Yang, Baoling Guo, Baiheng Wu, Rongrong Liu, Shikai Zhang, Peng Zhao, Jian Ruan, Xingyu Lu, Kai Liu, Dong Chen

Advanced Functional Materials· Volume 34· Issue 14
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Source abstract

Abstract

Abstract High‐performance bio‐based fibers have unique advantages in biocompatibility for biomedical applications, such as sutures, hernia patches, and blood vessels. Herein, strong and tough biofibers based on regenerated silk fibroins (RSFs) are designed by a dual‐crosslinking strategy and prepared continuously in situ via a single‐channel microfluidic device. During the wet spinning process, covalent bonds between tyrosines are introduced by photo crosslinking and coordination interactions of Zn2+ ions with serines are built between RSFs, forming a dual‐crosslinked, and inter‐connected network and effectively improving the mechanical performances of RSF fibers. By optimizing the wet spinning parameters and applying an optimal post‐stretching treatment, dual‐crosslinked RSF fibers exhibit an excellent tensile strength of 891 MPa, a remarkable Young's modulus of 15.0 GPa, a large tensile strain of 20.1%, and an outstanding toughness of 114 MJ m−3, which are superior to other regenerated biofibers. In addition to the outstanding mechanical performances, dual‐crosslinked RSF fibers also possess excellent temperature adaptability, fatigue resistance, biocompatibility, and biodegradability, making them ideal candidates for biomedical applications. In vivo tests of dual‐crosslinked RSF fibers as sutures demonstrate a good wound healing performance with smaller scar and lower inflammation.
Source: crossref · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Silk-based biomaterials and applications · Electrospun Nanofibers in Biomedical Applications · Surface Modification and Superhydrophobicity

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Medical Oncology The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310003 P. R. China

College of Energy Engineering and State Key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou Zhejiang 310003 P. R. China

College of Chemical and Biological Engineering Zhejiang Key Laboratory of Smart Biomaterials Zhejiang University Hangzhou Zhejiang 310027 P. R. China

Longyan First Affiliated Hospital of Fujian Medical University Longyan Fujian 364000 P. R. China

College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material Technology Ministry of Education Hangzhou Normal University Hangzhou 311121 P. R. China

Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province Instrumentation and Service Center for Molecular Sciences Westlake University Hangzhou Zhejiang Province 310024 P. R. China

State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China

Department of Chemistry Tsinghua University Beijing 100084 P. R. China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China

References (43)

Show source-provided references
1. 10.1002/anie.20200239910.1002/anie.202002399 ↗
2. 10.1002/ange.20191239910.1002/ange.201912399 ↗
3. 10.1016/j.cclet.2023.10845710.1016/j.cclet.2023.108457 ↗
4. 10.1002/anie.20201284810.1002/anie.202012848 ↗
5. 10.1016/j.cclet.2022.04.07910.1016/j.cclet.2022.04.079 ↗
6. 10.1016/j.eng.2021.06.03010.1016/j.eng.2021.06.030 ↗
7. 10.1002/adfm.20211215610.1002/adfm.202112156 ↗
8. 10.1002/adma.20170249810.1002/adma.201702498 ↗
9. 10.1038/s41570-021-00325-x10.1038/s41570-021-00325-x ↗
10. 10.1016/j.nantod.2022.10148510.1016/j.nantod.2022.101485 ↗
11. 10.1021/acsnano.2c0344010.1021/acsnano.2c03440 ↗
12. 10.1038/nmat311510.1038/nmat3115 ↗
13. 10.31635/ccschem.020.20200023110.31635/ccschem.020.202000231 ↗
14. 10.1126/science.118893610.1126/science.1188936 ↗
15. 10.1038/nmat270410.1038/nmat2704 ↗
16. 10.1038/nchembio.178910.1038/nchembio.1789 ↗
17. Vollrath F. · J. Biotechnol. · 2000 · 74 · 67
18. 10.1002/admi.20220196210.1002/admi.202201962 ↗
19. 10.1002/sstr.20230008010.1002/sstr.202300080 ↗
20. 10.1242/jeb.37.4.88910.1242/jeb.37.4.889 ↗
21. 10.1016/S0022-2836(61)80028-410.1016/S0022-2836(61)80028-4 ↗
22. 10.1098/rstb.1975.006210.1098/rstb.1975.0062 ↗
23. 10.31635/ccschem.020.20200033010.31635/ccschem.020.202000330 ↗
24. 10.1002/adfm.20140052610.1002/adfm.201400526 ↗
25. 10.1002/adhm.20190064410.1002/adhm.201900644 ↗
26. 10.1039/C5TB00970G10.1039/C5TB00970G ↗
27. 10.1038/nmat446310.1038/nmat4463 ↗
28. 10.1038/nature0408510.1038/nature04085 ↗
29. 10.1002/anie.20181073510.1002/anie.201810735 ↗
30. 10.1016/j.jmbbm.2014.04.00810.1016/j.jmbbm.2014.04.008 ↗
31. 10.1021/acs.jafc.2c0134910.1021/acs.jafc.2c01349 ↗
32. 10.1126/science.116816210.1126/science.1168162 ↗
33. 10.1016/j.cej.2020.12679310.1016/j.cej.2020.126793 ↗
34. 10.1021/acssuschemeng.9b0271310.1021/acssuschemeng.9b02713 ↗
35. 10.1038/s41467-023-35807-710.1038/s41467-023-35807-7 ↗
36. 10.3390/polym1212293610.3390/polym12122936 ↗
37. 10.1016/j.jmst.2020.02.08610.1016/j.jmst.2020.02.086 ↗
38. 10.1002/jrs.477610.1002/jrs.4776 ↗
39. 10.1038/s41598-018-33935-510.1038/s41598-018-33935-5 ↗
40. Gunvanthrao Yernale N. · Bioinorg. Chem. Appl. · 2014 · 2014
41. 10.1021/la010791y10.1021/la010791y ↗
42. 10.1126/science.aaj215610.1126/science.aaj2156 ↗
43. 10.1038/418741a10.1038/418741a ↗