DataVXAdvanced Functional MaterialsPaper
journal article·2022-10

A Smart Silk‐Based Microneedle for Cancer Stem Cell Synergistic Immunity/Hydrogen Therapy

Jingbo Yang, Guangmeng Li, Jun Yuan, Sibo Jing, Xiangjiang Wang, Fanwen Yang, Yang Liu, Youde Ding, Gang Li, Guoxi Xie, Ailin Tao, Ming Liu, Maobin Xie

Advanced Functional Materials· Volume 32· Issue 41
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Source abstract

Abstract

Abstract Cancer stem cells (CSCs) are responsible for the melanoma recurrence, progression, and ineffective therapy. Despite striking anti‐CSCs results in immunotherapy with anti‐programmed death‐1 antibodies (aPD‐1), the therapeutic efficacy is restricted by the evolution of immune evasion of CSCs. Here, a wearable silk‐based microneedle device (SMND) integrating a synergistic immunity and hydrogen therapy is developed. The device mainly consists of a double‐layered MN patch (DLMNP), which employs aPD‐1 loaded silk fibroin (SF) as the inner matrix for immunotherapy, while ammonia borane‐loaded mesoporous silica nanoparticles (AB‐MSN) encapsulated polycaprolactone as the outer thermal‐responsive coating for H2 releasing. SMND can realize thermally responsive drug release triggered by a smartphone for a sustained anti‐CSCs therapy. In B16F10‐CSCs bearing mice melanoma models, the results demonstrates that the synergistic treatment strategy can realize a satisfying antitumor and anti‐CSCs efficacy, which is accompanied by a minimized systemic toxicity. In summary, the smart and synergistic anti‐CSCs features endow SMND as a highly functional platform, which can be potentially extended to chronic disease therapy.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advancements in Transdermal Drug Delivery · Exercise and Physiological Responses · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan People's Hospital Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation School of Biomedical Engineering Guangzhou Medical University Guangzhou 511436 P. R. China

Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments School of Biomedical Engineering Sun Yat‐Sen University Guangzhou 510006 China

The Second Affiliated Hospital The State Key Laboratory of Respiratory Disease Provincial Key Laboratory of Allergy & Clinical Immunology Guangzhou Medical University Guangzhou 510260 China

Affiliated Cancer Hospital and Institute of Guangzhou Medical University Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation School of Basic Medical Science Guangzhou Medical University Guangzhou 511436 China

The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan People's Hospital Qingyuan 511518 P. R. China

National Engineering Laboratory for Modern Silk College of Textile and Clothing Engineering Soochow University Suzhou 215123 China

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