A Conformable and Tough Janus Adhesive Patch with Limited 1D Swelling Behavior for Internal Bioadhesion

Abstract Advanced bioadhesion techniques have offered unprecedented opportunities for life‐saving internal surgical procedures. However, most existing bioadhesives failed to rapidly establish long‐lasting reliable biointerface and effectively reconstruct normal physiological function in the body fluid‐rich and inevitable dynamic internal environment. Herein, a PEGylated poly(glycerol sebacate)‐based Janus adhesive patch (PEGS‐based JAP) is developed by integrating physically crosslinked guanidinylated PEGS (PEGSG) and acryloylated PEGS‐chemically crosslinked poly(acrylic acid)‐N‐hydrosuccinimide ester (PEGSA‐crosslinked PAAc‐NHS) with a single‐sided zwitterionic polymer‐interpenetrated layer. The dry JAP can rapidly absorb the unpleasant interfacial water and effectively form strong physical interactions with wet tissues. Benefiting from the amphiphilic nature of PEGSG and a simple spatial‐confined drying process, the JAP is allowed to resist excessive swelling and limitedly swell along one direction to avoid deterioration of the as‐established conformable patch‐tissue interface. Moreover, covalent interactions formed subsequently can further improve the adhesive strength and ensure a long‐lasting reliable adhesion. Meanwhile, the notch‐insensitive and puncture‐resistant JAP can achieve tough adhesion to adapt to the dynamic conditions owing to the highly efficient energy‐dissipation mechanism of the physically cross‐linked network. Combining the above ideal features with the desirable postoperative anti‐adhesion ability, the PEGS‐based JAP is demonstrated to be a promising candidate for internal tissue adhesion and function reconstruction.