Polymeric Smart Coating Strategy for Titanium Implants
Source abstract
Abstract
Hydrogel coatings of modified hyaluronan on smooth titanium oxide surfaces that mimic orthopedics implant have been characterized using quartz crystal microbalance and neutron reflectivity measurements. Adsorption of bone morphogenetic protein‐2, BMP‐2, on a bare titanium oxide surface is compared to that on titanium oxide coated with hyaluronan with different chemical modifications, the most important being hyaluronan with bisphosphonate groups. Release of the BMP‐2 from these coatings was triggered by calcium ions. The amount of protein on the surface and the release both depend on the type of hyaluronan coating. We conclude that titanium oxide coated with bisphosphonate modified hyaluronan surfaces provides an excellent material for growth factor delivery.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Hydrogels: synthesis, properties, applications · Polymer Surface Interaction Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Science for Life Laboratory, Department of Chemistry – Ångström Laboratory Uppsala University Box 538, 751 21 Uppsala Sweden
Institut Laue‐Langevin 6 Rue Jules Horowitz, BP 156 380 42 Grenoble France
Department of Physics and Astronomy: Materials Physics Uppsala University Box 516 751 20 Uppsala Sweden
References (43)
Show source-provided references
1. 10.1098/rsif.2008.015110.1098/rsif.2008.0151 ↗
2. 10.1007/s10195-003-0021-610.1007/s10195-003-0021-6 ↗
3. 10.1016/S0022-3913(11)60133-910.1016/S0022-3913(11)60133-9 ↗
4. Chiba A. · Sci. Technol. Energ. Mater. · 2009 · 70 · 68
5. 10.1016/j.biomaterials.2004.11.04410.1016/j.biomaterials.2004.11.044 ↗
6. 10.1016/j.jeurceramsoc.2007.12.00110.1016/j.jeurceramsoc.2007.12.001 ↗
7. Park J. W. · Int. J. Oral Maxillofac. Implants · 2007 · 22 · 533
8. 10.5435/00124635-200109000-0000110.5435/00124635-200109000-00001 ↗
9. 10.1126/science.106740410.1126/science.1067404 ↗
10. 10.1016/j.biomaterials.2010.05.04710.1016/j.biomaterials.2010.05.047 ↗
11. 10.1016/j.bone.2010.09.02910.1016/j.bone.2010.09.029 ↗
12. 10.1046/j.1365-2796.1997.00170.x10.1046/j.1365-2796.1997.00170.x ↗
13. 10.1021/bm049346i10.1021/bm049346i ↗
14. 10.1016/j.biomaterials.2011.04.03010.1016/j.biomaterials.2011.04.030 ↗
15. 10.1002/jbm.a.3228910.1002/jbm.a.32289 ↗
16. 10.1021/cm300298n10.1021/cm300298n ↗
17. 10.1258/000456301190103710.1258/0004563011901037 ↗
18. 10.1016/j.molmed.2004.05.00710.1016/j.molmed.2004.05.007 ↗
19. 10.1016/S0142-9612(00)00234-910.1016/S0142-9612(00)00234-9 ↗
20. 10.1007/s10856-009-3771-810.1007/s10856-009-3771-8 ↗
21. 10.1016/0927-7757(95)03262-210.1016/0927-7757(95)03262-2 ↗
22. 10.1126/science.320124110.1126/science.3201241 ↗
23. 10.1177/15440591070860011410.1177/154405910708600114 ↗
24. 10.1016/j.bone.2012.04.00410.1016/j.bone.2012.04.004 ↗
25. 10.1089/ten.tea.2010.055510.1089/ten.tea.2010.0555 ↗
26. 10.1016/j.jconrel.2011.02.00310.1016/j.jconrel.2011.02.003 ↗
27. 10.1016/j.jcis.2007.07.02910.1016/j.jcis.2007.07.029 ↗
28. 10.1186/1559-4106-8-2110.1186/1559-4106-8-21 ↗
29. 10.1093/glycob/10.6.58710.1093/glycob/10.6.587 ↗
30. I.Berts Doctoral Thesis Uppsala University Uppsala2013.
31. 10.1006/jmbi.1999.259010.1006/jmbi.1999.2590 ↗
32. 10.1140/epje/i2013-13070-710.1140/epje/i2013-13070-7 ↗
33. 10.1021/bm400639e10.1021/bm400639e ↗
34. 10.1002/jbm.b.3145610.1002/jbm.b.31456 ↗
35. 10.1002/term.159310.1002/term.1593 ↗
36. 10.1021/la970815u10.1021/la970815u ↗
37. F.Höök Doctoral Thesis Chalmers Technical University Göteborg1997.
38. 10.1007/BF0133793710.1007/BF01337937 ↗
39. 10.1016/S0956-5663(02)00050-710.1016/S0956-5663(02)00050-7 ↗
40. 10.1238/Physica.Regular.059a0039110.1238/Physica.Regular.059a00391 ↗
41. 10.1016/j.colsurfb.2010.01.02210.1016/j.colsurfb.2010.01.022 ↗
42. 10.1007/s00339020161110.1007/s003390201611 ↗
43. A. R.Rennie http://material.fysik.uu.se/Group_members/adrian/cprof.htm 2011.