Formation and Topotactical Orientation of Fibrinogen Nanofibrils on Graphite Nanostructures

We studied the adsorption of human plasma fibrinogen and investigated the formation of amyloid-like fibrinogen nanofibrils and fibrinogen networks in the absence of thrombin and Ca·2+ with high resolution atomic force microscopy (AFM). We propose a possible mechanisms for the surface nanostructure mediated self assembly of fibrinogen molecules and the formation of fibrinogen nanofibrils and nanofibril networks in the absence of thrombin.