Cell receptor interaction chromatography: importance of corrosion processes

AbstractCorrosion is a term traditionally describing degradation processes in metals. Modern dictionaries explain corrosion as: 'erosion by chemical action' or 'a state of deterioration in metals caused by oxidation or chemical action'. Erosion by chemical action applies to degradation processes in both metals and polymers, with humidity as one principal actor. In polymers, extended humidity exposure can result in manifest corrosion. Less clear is the action of transient humidity exposure, causing corrosion, or reversible effects mistakenly interpreted as corrosion. Effects of transient humidity exposure on polymers have been recently investigated by contact angle measurements. However, contact angles are insensitive to various parameters, including changes in topography. In this paper the author illustrates the importance of minimal effects of corrosion in polymers, exemplary for the method of cell receptor interaction chromatography (CRIC), a method initially designed to predict specific biocompatibilit...