Hydrothermal Deposition of PCN‐224 on 3D‐Printed Porous β‐Ca2SiO4 Scaffolds for Bone Regeneration
Source abstract
Abstract
3D‐printed bioceramics derived from silicone resin are of great interest in bone tissue engineering owing to their simple processes and low cost. Herein, PCN‐224, as a subclass of metal−organic frameworks (MOFs), is successfully fabricated and deposited on the surface of 3D‐printed porous β‐Ca2SiO4 (C2S) scaffolds. The composite scaffolds possess uniform interconnected macropores (≈400 μm), with increased porosity and slower degradation. The results indicate that deposition of PCN‐224 significantly promotes cell proliferation and the expression of osteogenesis‐related genes. Moreover, the composite scaffolds significantly improve calvarial defect healing in rats, compared with C2S scaffolds. Therefore, the PCN‐224‐modified 3D‐printed porous C2S composite scaffolds are promising candidates for bone tissue engineering.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · MXene and MAX Phase Materials · Orthopaedic implants and arthroplasty
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Orthopaedics Shanghai Pudong Hospital Fudan University Pudong Medical Center Shanghai 201399 China
School of Materials Science and Engineering University of Shanghai for Science and Technology Shanghai 200093 China
Department of Orthopaedics Shanghai Public Health Clinical Center Fudan University Shanghai 200032 China
Funding
Fudan University
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