DataVXAdvanced Engineering MaterialsPaper
journal article·2024-03Open access

Mechanical Investigation of Solid MNs Penetration into Skin Using Finite Element Analysis

Tianqi Liu, Yanfang Sun, Wenjing Zhang, Rui Wang, Xinyu Lv, Lei Nie, Amin Shavandi, Khaydar E. Yunusov, Guohua Jiang

Advanced Engineering Materials· Volume 26· Issue 5
Publisher pageOpen full text
Source abstract

Abstract

In the past two decades, microneedles (MNs) patches as a promising platform have been extensively investigated for transdermal delivery of drug drugs, cells, and active substances and extraction of bio‐fluids. To realize painless, efficacious, and safe transdermal delivery, these MNs must penetrate the skin to the appropriate depth without breaking or bending. Therefore, effective prediction of mechanical properties such as skin penetration of microneedles is crucial for the material and structural design of MNs. In this article, a numerical simulation of the insertion process of the microneedle into various types of skin modeling is reported using the finite element method. The effective stress failure criterion has been coupled with the element deletion technique to predict the complete insertion process. The numerical results show a good agreement with the reported experimental data for the deformation and failure of the skin and the insertion force.
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Research context

OpenAlex topics: Advancements in Transdermal Drug Delivery · Contact Dermatitis and Allergies · Plant Surface Properties and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Materials Science and Engineering Zhejiang Sci‐Tech University Hangzhou 310018 China

International Scientific and Technological Cooperation Base of Intelligent Biomaterials and Functional Fibers of Zhejiang Province Hangzhou 310018 China

College of Life Sciences and Medicine Zhejiang Sci‐Tech University Hangzhou 310018 Zhejiang China

College of Life Sciences Xinyang Normal University Xinyang 464000 China

École polytechnique de Bruxelles Université libre de Bruxelles (ULB) 3BIO10 BioMatter, Avenue F.D. Roosevelt, 50 ‐ CP 165/61 Brussels 1050 Belgium

Institute of Polymer Chemistry and Physics Uzbekistan Academy of Sciences Tashkent 100128 Uzbekistan

Funding

Natural Science Foundation of Zhejiang Province · National Natural Science Foundation of China

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