Point‐of‐Care Diagnostic Platforms for Loop‐Mediated Isothermal Amplification
Source abstract
Abstract
The loop‐mediated isothermal amplification (LAMP) method is one of the Nucleic acid amplification tests (NAATs) that allows for the amplification of target regions without using a thermal cycle. With its unique primer design, LAMP ensures the rapid replication of the targeted DNA region with high specificity and high efficiency. LAMP technology is used for diagnostic purposes in pathogen detection due to its ease of use, low cost, and simplicity without requiring complex equipment. A wide range of LAMP diagnostic platforms have been developed for applications in bacteria, virus, and parasitic pathogen detection. Herein, the methodology of LAMP technology and its applications in pathogen detection and SNP genotyping and mutation detection are discussed. Point‐of‐care (PoC) LAMP platforms designed with the principles of microfluidic chip technology, including LAMP‐on‐a‐chip, paper‐based LAMP, and smartphone‐based LAMP applications have been elaborated. LAMP technology represents a fast, robust, and reliable diagnostic platform for point‐of‐care testing.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Biosensors and Analytical Detection · Innovative Microfluidic and Catalytic Techniques Innovation · Advanced biosensing and bioanalysis techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Graduate School of Sciences & Engineering Koç University Istanbul 34450 Turkey
Boğaziçi Institute of Biomedical Engineering Boğaziçi University Istanbul 34684 Turkey
Department of Mechanical Engineering Koç University Sariyer Istanbul 34450 Turkey
Department of Chemical Engineering Imperial College London London SW7 2AZ UK
Koç University Translational Medicine Research Center (KUTTAM) Koç University Istanbul 34450 Turkey
Koç University Arçelik Research Center for Creative Industries (KUAR) Koç University Istanbul 34450 Turkey
Funding
Alexander von Humboldt-Stiftung · HORIZON EUROPE Marie Sklodowska-Curie Actions
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