Photothermal phase-responsive nanocomposites boost cGAS/STING-Driven antitumor immunity via mitochondrial DNA damage
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (46)
Show source-provided references
1. PD-1/PD-L1 immune checkpoint blockade in breast cancer: research insights and sensitization strategies10.1186/s12943-024-02176-8 ↗
2. Eradication of Triple-negative Breast Cancer Cells by Targeting Glycosylated PD-L110.1016/j.ccell.2018.01.009 ↗
3. Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial10.1038/s41591-019-0432-4 ↗
4. Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer10.1016/j.immuni.2025.03.002 ↗
5. Contrasting cytotoxic and regulatory T cell responses underlying distinct clinical outcomes to anti-PD-1 plus lenvatinib therapy in cancer10.1016/j.ccell.2025.01.001 ↗
6. Epigenetic strategies synergize with PD-L1/PD-1 targeted cancer immunotherapies to enhance antitumor responses10.1016/j.apsb.2019.09.006 ↗
7. The cGAS-STING pathway and cancer10.1038/s43018-022-00468-w ↗
8. The cGAS-STING pathway as a therapeutic target in inflammatory diseases10.1038/s41577-021-00524-z ↗
9. New frontiers in the cGAS-STING intracellular DNA-sensing pathway10.1016/j.immuni.2024.02.019 ↗
10. Engineering Semiconducting Polymeric Nanoagonists Potentiate cGAS-STING Pathway Activation and Elicit Long Term memory against Recurrence in Breast Cancer. Advanced materials (Deerfield Beach
11. cGAS-STING pathway in cancer biotherapy10.1186/s12943-020-01247-w ↗
12. Molecular mechanisms and cellular functions of cGAS-STING signalling10.1038/s41580-020-0244-x ↗
13. Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling10.1016/j.immuni.2022.06.007 ↗
14. TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS10.1016/j.cell.2020.09.020 ↗
15. TRIM21 inhibits irradiation-induced mitochondrial DNA release and impairs antitumour immunity in nasopharyngeal carcinoma tumour models10.1038/s41467-023-36523-y ↗
16. A full active pharmaceutical ingredients-based nanoplatform potentiates tumor immunotherapy via multidimensional cGAS-STING pathway activation10.1016/j.cej.2026.176643 ↗
17. Cisplatin nephrotoxicity: new insights and therapeutic implications10.1038/s41581-022-00631-7 ↗
18. Mitochondrial damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury10.1016/j.celrep.2019.09.050 ↗
19. Cisplatin in cancer therapy: molecular mechanisms of action10.1016/j.ejphar.2014.07.025 ↗
20. Intranasal ondansetron microemulsion counteracting the adverse effects of cisplatin: animal study10.1007/s43440-022-00435-3 ↗
21. The EPR effect and beyond: strategies to improve tumor targeting and cancer nanomedicine treatment efficacy10.7150/thno.49577 ↗
22. Fang · 2024 · 29
23. Bioorthogonal Guided Activation of cGAS-STING by AIE Photosensitizer Nanoparticles for Targeted Tumor Therapy and Imaging10.1002/adma.202305668 ↗
24. A Copper-based Photothermal-Responsive Nanoplatform Reprograms Tumor Immunogenicity via Self-Amplified Cuproptosis for Synergistic Cancer Therapy10.1002/advs.202500652 ↗
25. Comparison of Tumor Non-specific and PD-L1 specific Imaging by Near-Infrared Fluorescence/Cerenkov Luminescence Dual-Modality In-situ Imaging10.1177/15353508241261473 ↗
26. Regulating Chondro-Bone Metabolism for Treatment of Osteoarthritis via High-Permeability Micro/Nano Hydrogel Microspheres
27. Hyaluronic Acid Receptor-Mediated Nanomedicines and Targeted Therapy
28. Chen L, Ming H, Li B, Yang C, Liu S, Gao Y, et al. Tumor-Specific Nano-Herb Delivery System with High L-Arginine Loading for Synergistic Chemo and Gas Therapy against Cervical Cancer. Small (Weinheim an der Bergstrasse, Germany). 2024e2403869.10.1002/smll.202403869 ↗
29. Improved Immune Response for Colorectal Cancer Therapy Triggered by Multifunctional Nanocomposites with Self-Amplifying Antitumor Ferroptosis10.1021/acsami.3c16813 ↗
30. CRCs-CAFs crosstalk-targeted nano-delivery system reprograms tumor microenvironment for oxaliplatin resistance reversing and liver metastasis inhibition in colorectal cancer
31. An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy10.1038/s41467-020-15591-4 ↗
32. Semiconducting polymer nanomanipulators for thermal sensitization and metastasis-inhibited synergistic cancer therapy10.1016/j.nantod.2022.101691 ↗
33. Single NIR Laser-Activated Multifunctional Nanoparticles for Cascaded Photothermal and Oxygen-Independent Photodynamic Therapy10.1007/s40820-019-0298-5 ↗
34. Li X, Ma Y, Xin Y, Ma F, Gao H. Tumor-Targeting Nanoassembly for Enhanced Colorectal Cancer Therapy by Eliminating IntratumoralFusobacterium nucleatum. ACS APPL MATER INTER. 20233c-1210c.
35. Synergistic reinforcing of Immunogenic Cell Death and Transforming Tumor‐Associated Macrophages Via a Multifunctional Cascade Bioreactor for Optimizing Cancer Immunotherapy10.1002/adma.202207593 ↗
36. Composite Hydrogel for Spatiotemporal Lipid intervention of Tumor Milieu
37. Flower-like Cu(9)S(8) nanocatalysts with highly active sites for synergistic NIR-II photothermal therapy and chemodynamic therapy10.1039/D3TB00488K ↗
38. Mitochondrial DNA-triggered innate immune response: mechanisms and diseases10.1038/s41423-023-01086-x ↗
39. Cisplatin-induced disruption of mitochondrial divisome leads to enhanced cisplatin resistance in cholangiocarcinoma10.1016/j.jhep.2025.03.028 ↗
40. A Multichannel Ca2+ Nanomodulator for Multilevel Mitochondrial Destruction‐Mediated Cancer Therapy10.1002/adma.202007426 ↗
41. Icariside I enhances the effects of immunotherapy in gastrointestinal cancer via targeting TRPV4 and upregulating the cGAS-STING-IFN-I pathway
42. Cancer Immunotherapy based on Cell Membrane‐Coated Nanocomposites Augmenting cGAS/STING Activation by Efferocytosis Blockade
43. Cuproptosis Induced by ROS Responsive Nanoparticles with Elesclomol and copper combined with αPD-L1 for Enhanced Cancer Immunotherapy. Advanced materials (Deerfield Beach
44. Immunogenic cell death and DAMPs in cancer therapy10.1038/nrc3380 ↗
45. Synergistic gambogic acid/Ga3? remodels the immunosuppressive tumor microenvironment to enhance triple-negative breast cancer therapy10.1186/s12951-025-03758-4 ↗
46. A Self-Adaptive Rhodium(I) Complex-based Nanoplatform with Type II Immunogenic Cell Death for Near-Infrared Phosphorescence Imaging and Cancer Immunotherapy10.1002/adhm.202501871 ↗