Metal–organic frameworks: from porous material to next-generation biomaterials

1. Li H, Eddaoudi M (1999) Design and synthesis of an exceptionally stable and highly porous metal-organic framework. Nature 402:276–27910.1038/46248 ↗

2. Li B, Wen HM, Cui Y, Zhou W, Qian G, Chen B (2016) Emerging multifunctional metal–organic framework materials. Adv Mater 28:8819–886010.1002/adma.201601133 ↗

3. Liu B, Jiang M, Zhu D, Zhang J, Wei G (2022) Metal-organic frameworks functionalized with nucleic acids and amino acids for structure-and function-specific applications: a tutorial review. Chem Eng J 428:13111810.1016/j.cej.2021.131118 ↗

4. Doonan C, Riccò R, Liang K, Bradshaw D, Falcaro P (2017) Metal–organic frameworks at the biointerface: synthetic strategies and applications. Acc Chem Res 50:1423–143210.1021/acs.accounts.7b00090 ↗

5. Ahmed A, McHugh D, Papatriantafyllopoulou C (2022) Synthesis and biomedical applications of highly porous metal–organic frameworks. Molecules 27:658510.3390/molecules27196585 ↗

6. Mehta J, Bhardwaj N, Bhardwaj SK, Kim K-H, Deep A (2016) Recent advances in enzyme immobilization techniques: metal-organic frameworks as novel substrates. Coord Chem Rev 322:30–4010.1016/j.ccr.2016.05.007 ↗

7. Yang J, Yang YW (2020) Metal–organic frameworks for biomedical applications. Small 16:190684610.1002/smll.201906846 ↗

8. Anderson SL, Stylianou KC (2017) Biologically derived metal organic frameworks. Coord Chem Rev 349:102–12810.1016/j.ccr.2017.07.012 ↗

9. Cai H, Huang Y-L, Li D (2019) Biological metal–organic frameworks: structures, host–guest chemistry and bio-applications. Coord Chem Rev 378:207–22110.1016/j.ccr.2017.12.003 ↗

10. Liang W, Wied P, Carraro F, Sumby CJ, Nidetzky B, Tsung C-K et al (2021) Metal–organic framework-based enzyme biocomposites. Chem Rev 121:1077–112910.1021/acs.chemrev.0c01029 ↗

11. Weng Y, Chen R, Hui Y, Chen D, Zhao C-X (2024) Boosting enzyme activity in enzyme metal–organic framework composites. Chem Bio Eng 1:99–11210.1021/cbe.3c00091 ↗

12. Tian Y, Wang B, Zhang Z, Kai T, Wu P, Ding P (2025) Recent advances in metal–organic frameworks for antibacterial applications: mechanisms and emerging strategies. RSC Adv 15:26710–2672710.1039/D5RA02955D ↗

13. Harjeet S, Srivastava (2026) Frameworks for the future: metal organic frameworks and their composites based solutions for hydrogen storage. J Energy Storage 148:12034610.1016/j.est.2026.120346 ↗

14. Abánades Lázaro I, Chen X, Ding M, Eskandari A, Fairen-Jimenez D, Giménez-Marqués M et al (2024) Metal–organic frameworks for biological applications. Nat Rev Methods Primers 4:4210.1038/s43586-024-00320-8 ↗

15. Awasthi G, Shivgotra S, Nikhar S, Sundarrajan S, Ramakrishna S, Kumar P (2022) Progressive trends on the biomedical applications of metal organic frameworks. Polymers (Basel) 14:471010.3390/polym14214710 ↗

16. Moharramnejad M, Ehsani A, Salmani S, Shahi M, Malekshah RE, Robatjazi ZS et al (2022) Zinc-based metal-organic frameworks: synthesis and recent progress in biomedical application. J Inorg Organomet Polym Mater 32:3339–335410.1007/s10904-022-02385-y ↗

17. Lin C, Guo X, Mo F, Sun D (2023) Different dimensional copper-based metal–organic frameworks with enzyme-mimetic activity for antibacterial therapy. Int J Mol Sci 24:317310.3390/ijms24043173 ↗

18. Yuan A, Lu Y, Zhang X, Chen Q, Huang Y (2020) Two-dimensional iron MOF nanosheet as a highly efficient nanozyme for glucose biosensing. J Mater Chem B 8:9295–930310.1039/D0TB01598A ↗

19. Xian S, Lin Y, Wang H, Li J (2021) Calcium‐based metal–organic frameworks and their potential applications. Small 17:200516510.1002/smll.202005165 ↗

20. Wiśniewska P, Haponiuk J, Saeb MR, Rabiee N, Bencherif SA (2023) Mitigating metal-organic framework (MOF) toxicity for biomedical applications. Chem Eng J 471:14440010.1016/j.cej.2023.144400 ↗

21. Wang A, Walden M, Ettlinger R, Kiessling F, Gassensmith JJ, Lammers T et al (2024) Biomedical metal–organic framework materials: perspectives and challenges. Adv Funct Mater 34:230858910.1002/adfm.202308589 ↗

22. Chattopadhyay K, Mandal M, Maiti DK (2024) A review on zirconium-based metal–organic frameworks: synthetic approaches and biomedical applications. Mater Adv 5:51–6710.1039/D3MA00735A ↗

23. Ahmadi M, Ayyoubzadeh SM, Ghorbani-Bidkorbeh F, Shahhosseini S, Dadashzadeh S, Asadian E et al (2021) An investigation of affecting factors on MOF characteristics for biomedical applications: a systematic review. Heliyon. https://doi.org/10.1016/j.heliyon.2021.e0691410.1016/j.heliyon.2021.e06914 ↗

24. Liang S, Wu X-L, Xiong J, Zong M-H, Lou W-Y (2020) Metal-organic frameworks as novel matrices for efficient enzyme immobilization: an update review. Coord Chem Rev 406:21314910.1016/j.ccr.2019.213149 ↗

25. Cai X, Xie Z, Li D, Kassymova M, Zang S-Q, Jiang H-L (2020) Nano-sized metal-organic frameworks: synthesis and applications. Coord Chem Rev 417:21336610.1016/j.ccr.2020.213366 ↗

26. Kidanemariam A, Cho S (2025) Recent advances in metal-organic framework-based nanozymes for intelligent microbial biosensing: a comprehensive review of biomedical and environmental applications. Biosens 15:43710.3390/bios15070437 ↗

27. Li Y, Chai H, Yuan Z, Huang C, Wang S, Sun Y et al (2024) Metal–organic framework-engineered enzyme/nanozyme composites: preparation, functionality, and sensing mechanisms. Chem Eng J 496:15388410.1016/j.cej.2024.153884 ↗

28. Cai W, Wang J, Chu C, Chen W, Wu C, Liu G (2019) Metal–organic framework‐based stimuli‐responsive systems for drug delivery. Adv Sci 6:180152610.1002/advs.201801526 ↗

29. Zhou Z, Vázquez-González M, Willner I (2021) Stimuli-responsive metal–organic framework nanoparticles for controlled drug delivery and medical applications. Chem Soc Rev 50:4541–456310.1039/D0CS01030H ↗

30. Du C, Xu Y, Wei G (2025) Recent advances in biomolecule-engineered metal-organic frameworks (Bio-MOFs): from design, bioengineering, and structural/functional regulation to biocatalytic applications. Chem Rec 25:e20250000110.1002/tcr.202500001 ↗

31. Xia N, Zheng C, Liu G (2025) Fluorescent–electrochemical–colorimetric triple-model immunoassays with multifunctional metal-organic frameworks for signal amplification. Biosensors 15:37610.3390/bios15060376 ↗

32. Roszkowski S, Durczynska Z (2025) Advantages and limitations of nanostructures for biomedical applications. Adv Clin Exp Med 34:447–45610.17219/acem/186846 ↗

33. He S, Wu L, Li X, Sun H, Xiong T, Liu J et al (2021) Metal-organic frameworks for advanced drug delivery. Acta Pharm Sin B 11:2362–239510.1016/j.apsb.2021.03.019 ↗

34. Cao J, Li X, Tian H (2020) Metal-organic framework (MOF)-based drug delivery. Curr Med Chem 27:5949–596910.2174/0929867326666190618152518 ↗

35. Zong Z, Tian G, Wang J, Fan C, Yang F, Guo F (2022) Recent advances in metal–organic-framework-based nanocarriers for controllable drug delivery and release. Pharmaceutics 14:279010.3390/pharmaceutics14122790 ↗

36. Vuong MDL, Horbenko Y, Frégnaux M, Christodoulou I, Martineau-Corcos C, Levitz P et al (2024) Degradation and erosion of metal–organic frameworks: comparative study of a nanomil-100 drug delivery system. ACS Appl Mater Interfaces 16:2086–210010.1021/acsami.3c14301 ↗

37. Christodoulou I, Lyu P, Soares CV, Patriarche G, Serre C, Maurin G et al (2023) Nanoscale iron-based metal–organic frameworks: incorporation of functionalized drugs and degradation in biological media. Int J Mol Sci 24:336210.3390/ijms24043362 ↗

38. Sun RWY, Zhang M, Li D, Zhang ZF, Cai H, Li M et al (2015) Dinuclear gold (I) pyrrolidinedithiocarbamato complex: cytotoxic and antimigratory activities on cancer cells and the use of metal–organic framework. Chem-Eur J 21:18534–1853810.1002/chem.201503656 ↗

39. Lin W, Hu Q, Jiang K, Yang Y, Yang Y, Cui Y et al (2016) A porphyrin-based metal–organic framework as a pH-responsive drug carrier. J Solid State Chem 237:307–31210.1016/j.jssc.2016.02.040 ↗

40. Xu Z, Hu L, Ming J, Cui X, Zhang M, Dou J et al (2020) Self-gated porous organic polymer as drug delivery system for pH stimuli-responsive controlled Quercetin release. Microporous Mesoporous Mater 303:11025910.1016/j.micromeso.2020.110259 ↗

41. Yang C, Shi Z, Feng C, Li R, Luo S, Li X et al (2020) An adjustable pH-responsive drug delivery system based on self-assembly polypeptide-modified mesoporous silica. Macromol Biosci 20:200003410.1002/mabi.202000034 ↗

42. Sivakumar P, Priyatharshni S, Nagashanmugam K, Thanigaivelan A, Kumar K (2017) Chitosan capped nanoscale Fe-MIL-88B-NH2 metal-organic framework as drug carrier material for the pH responsive delivery of doxorubicin. Mater Res Express 4:08502310.1088/2053-1591/aa822f ↗

43. Karimi S, Namazi H (2023) Fabrication of biocompatible magnetic maltose/MIL-88 metal–organic frameworks decorated with folic acid-chitosan for targeted and pH-responsive controlled release of doxorubicin. Int J Pharm 634:12267510.1016/j.ijpharm.2023.122675 ↗

44. Guillen SG, Parres-Gold J, Ruiz A, Lucsik E, Dao B, Hang TK et al (2022) pH-Responsive metal–organic framework thin film for drug delivery. Langmuir 38:16014–1602310.1021/acs.langmuir.2c02497 ↗

45. Tran VA, Lee S-W (2021) pH-triggered degradation and release of doxorubicin from zeolitic imidazolate framework-8 (ZIF8) decorated with polyacrylic acid. RSC Adv 11:9222–923410.1039/D0RA10423J ↗

46. Sontakke AD, Bhattacharjee A, Fopase R, Pandey LM, Purkait MK (2022) One-pot, sustainable and room temperature synthesis of graphene oxide-impregnated iron-based metal-organic framework (GO/MIL-100 (Fe)) nanocarriers for anticancer drug delivery systems. J Mater Sci 57:19019–1904910.1007/s10853-022-07773-w ↗

47. Jiang X-R, Mi J, Wang Y, Yin M, Tong Y, Zhu Y (2025) Application of metal-organic frameworks nanoparticles in the diagnosis and treatment of breast cancer. Int J Nanomedicine. https://doi.org/10.2147/ijn.s53442210.2147/ijn.s534422 ↗

48. Han I, Choi SA, Lee DN (2022) Therapeutic application of metal–organic frameworks composed of copper, cobalt, and zinc: their anticancer activity and mechanism. Pharmaceutics 14:37810.3390/pharmaceutics14020378 ↗

49. Sakamaki Y, Ozdemir J, Diaz Perez A, Heidrick Z, Watson O, Tsuji M et al (2020) Maltotriose conjugated metal–organic frameworks for selective targeting and photodynamic therapy of triple negative breast cancer cells and tumor associated macrophages. Adv Ther 3:200002910.1002/adtp.202000029 ↗

50. Li B, Yao X, Li J, Lu X, Zhang W, Duan W et al (2023) A tumor microenvironment-activated metal-organic framework–based nanoplatform for amplified oxidative stress–induced enhanced chemotherapy. J Biol Chem. https://doi.org/10.1016/j.jbc.2022.10274210.1016/j.jbc.2022.102742 ↗

51. Wang Y, Gao F, Li X, Niu G, Yang Y, Li H et al (2022) Tumor microenvironment-responsive fenton nanocatalysts for intensified anticancer treatment. J Nanobiotechnol 20:6910.1186/s12951-022-01278-z ↗

52. Meng H-M, Hu X-X, Kong G-Z, Yang C, Fu T, Li Z-H et al (2018) Aptamer-functionalized nanoscale metal-organic frameworks for targeted photodynamic therapy. Theranostics 8:433210.7150/thno.26768 ↗

53. Cao C, Wang X, Yang N, Song X, Dong X (2022) Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry. Chem Sci 13:863–88910.1039/D1SC05482A ↗

54. Kong H, Chu Q, Fang C, Cao G, Han G, Li X (2021) Cu–ferrocene‐functionalized CaO2 nanoparticles to enable tumor‐specific synergistic therapy with GSH depletion and calcium overload. Adv Sci 8:210024110.1002/advs.202100241 ↗

55. Hu Q, Xu K, Huang X, Huang S, Wang Z, Lu W et al (2024) Construction of an anticancer system based on medi-MOF-1 and Mn ions for theranostic application. J Mol Struct 1312:13846110.1016/j.molstruc.2024.138461 ↗

56. Wang J, Pan J, Tang Y, Chen J, Fei X, Xue W et al (2023) Advances of hafnium based nanomaterials for cancer theranostics. Front Chem 11:128392410.3389/fchem.2023.1283924 ↗

57. Lee J, Yu K, Davaa E, Jenjob R, Tran PH, Ryu D et al (2025) Autophagy-regulating, photothermal polydopamine-coated, and photodynamic zirconium/porphyrin-framed metal–organic frameworks for enhanced doxorubicin therapy in colon cancer. Biomater Res 29:021810.34133/bmr.0218 ↗

58. Zhang K, Meng X, Cao Y, Yang Z, Dong H, Zhang Y et al (2018) Metal–organic framework nanoshuttle for synergistic photodynamic and low‐temperature photothermal therapy. Adv Funct Mater 28:180463410.1002/adfm.201804634 ↗

59. Liu B, Duan H, Sun L, Liu Z, Sun Z, Chu H (2025) Core–shell structured metal–organic frameworks for pH-triggered combination photodynamic/chemotherapy-based cancer treatment. Biomater Res 29:013810.34133/bmr.0138 ↗

60. Liu B, Liu Z, Lu X, Wu P, Sun Z, Chu H et al (2023) Controllable growth of drug-encapsulated metal-organic framework (MOF) on porphyrinic MOF for PDT/chemo-combined therapy. Mater Des 228:11186110.1016/j.matdes.2023.111861 ↗

61. Zou Y, Chen J, Luo X, Qu Y, Zhou M, Xia R et al (2024) Porphyrin-engineered nanoscale metal-organic frameworks: enhancing photodynamic therapy and ferroptosis in oncology. Front Pharmacol 15:148116810.3389/fphar.2024.1481168 ↗

62. Ye Y, Zhao Y, Sun Y, Cao J (2022) Recent progress of metal-organic framework-based photodynamic therapy for cancer treatment. Int J Nanomedicine. https://doi.org/10.2147/ijn.s36275910.2147/ijn.s362759 ↗

63. Zhang S, Cao C, Lv X, Dai H, Zhong Z, Liang C et al (2020) AH 2 O 2 self-sufficient nanoplatform with domino effects for thermal-responsive enhanced chemodynamic therapy. Chem Sci 11:1926–193410.1039/C9SC05506A ↗

64. Hong L, Chen Q, Rao L, Wang Z, Wang B, He Q et al (2025) A multifunctional Fe-based metal-organic framework with ferroptosis for synergistic therapy. Appl Organomet Chem 39:e7014310.1002/aoc.70143 ↗

65. Ni K, Lan G, Lin W (2020) Nanoscale metal–organic frameworks generate reactive oxygen species for cancer therapy. ACS Cent Sci 6:861–86810.1021/acscentsci.0c00397 ↗

66. Akbar MU, Khattak S, Khan MI, Saddozai UAK, Ali N, AlAsmari AF et al (2023) A pH-responsive bi-MIL-88B MOF coated with folic acid-conjugated chitosan as a promising nanocarrier for targeted drug delivery of 5-Fluorouracil. Front Pharmacol 14:126544010.3389/fphar.2023.1265440 ↗

67. Liang J, Zhang W, Wang J, Li W, Ge F, Jin W et al (2023) Development of the Cu/ZIF-8 MOF acid-sensitive nanocatalytic platform capable of chemo/chemodynamic therapy with improved anti-tumor efficacy. ACS Omega 8:19402–1941210.1021/acsomega.3c00269 ↗

68. Jiang Q, Gao X, Zhang W, Chen Z (2023) Recent progress in metal–organic framework-based sonosensitizers for sonodynamic tumor therapy. Biomater Sci 11:4452–447010.1039/D3BM00556A ↗

69. Liang S, Xiao X, Bai L, Liu B, Yuan M, Ma P et al (2021) Conferring Ti‐based MOFs with defects for enhanced sonodynamic cancer therapy. Adv Mater 33:210033310.1002/adma.202100333 ↗

70. Zhang J, Li M, Liu M, Yu Q, Ge D, Zhang J (2024) Metal–organic framework nanomaterials as a medicine for catalytic tumor therapy: recent advances. Nanomaterials 14:79710.3390/nano14090797 ↗

71. Liu J, Yang Y, Zhu W, Yi X, Dong Z, Xu X et al (2016) Nanoscale metal−organic frameworks for combined photodynamic and radiation therapy in cancer treatment. Biomaterials 97:1–910.1016/j.biomaterials.2016.04.034 ↗

72. Li T, Gao M, Wu Z, Yang J, Mo B, Yu S et al (2023) Tantalum–zirconium Co‐doped metal–organic frameworks sequentially sensitize radio–radiodynamic–immunotherapy for metastatic osteosarcoma. Adv Sci 10:220677910.1002/advs.202206779 ↗

73. Xu Q, Zhan G, Zhang Z, Yong T, Yang X, Gan L (2021) Manganese porphyrin-based metal-organic framework for synergistic sonodynamic therapy and ferroptosis in hypoxic tumors. Theranostics 11:193710.7150/thno.45511 ↗

74. Dai L, Yao M, Fu Z, Li X, Zheng X, Meng S et al (2022) Multifunctional metal-organic framework-based nanoreactor for starvation/oxidation improved indoleamine 2, 3-dioxygenase-blockade tumor immunotherapy. Nat Commun 13:268810.1038/s41467-022-30436-y ↗

75. Süngü Akdogan CZ, Akbay Çetin E, Onur MA, Önel S, Tuncel A (2024) In vitro synergistic photodynamic, photothermal, chemodynamic, and starvation therapy performance of chlorin e6 immobilized, polydopamine-coated hollow, porous ceria-based, hypoxia-tolerant nanozymes carrying a cascade system. ACS Appl Bio Mater 7:2781–279310.1021/acsabm.3c01181 ↗

76. Yang J, Dai D, Zhang X, Teng L, Ma L, Yang Y-W (2023) Multifunctional metal-organic framework (MOF)-based nanoplatforms for cancer therapy: from single to combination therapy. Theranostics 13:29510.7150/thno.80687 ↗

77. Liu X, Zhu Y-X, Jia H-R, Zhang X, Gao G, Xu K-F et al (2023) A MOF-based nanobomb for tumor microvascular occlusion and combined tumor starvation therapy and chemotherapy. Mater Today Nano 24:10043010.1016/j.mtnano.2023.100430 ↗

78. Duman FD, Forgan RS (2021) Applications of nanoscale metal–organic frameworks as imaging agents in biology and medicine. J Mater Chem B 9:3423–344910.1039/D1TB00358E ↗

79. Liu Y, Jiang T, Liu Z (2022) Metal-organic frameworks for bioimaging: strategies and challenges. Nanotheranostics 6:14310.7150/ntno.63458 ↗

80. Zhang Z, Sang W, Xie L, Dai Y (2019) Metal-organic frameworks for multimodal bioimaging and synergistic cancer chemotherapy. Coord Chem Rev 399:21302210.1016/j.ccr.2019.213022 ↗

81. Chowdhury MA (2017) Metal-organic-frameworks for biomedical applications in drug delivery, and as MRI contrast agents. J Biomed Mater Res A 105:1184–119410.1002/jbm.a.35995 ↗

82. Hou M-J, Chen J-T, Jiang W-L, Zeng G-F, Zhan J, Mao G-J et al (2022) ATP fluorescent nanoprobe based on ZIF-90 and near-infrared dyes for imaging in tumor mice. Sens Actuators B Chem 369:13228610.1016/j.snb.2022.132286 ↗

83. Guo J-C, Deng S-H, Zhou S-M, Zhou X, Du J, Zhou S-H et al (2024) Responsive ZIF-90 nanocomposite material: targeted delivery of 10-hydroxycamptothecine to enhance the therapeutic effect of colon cancer (HCT116) cells. RSC Med Chem 15:2663–267610.1039/D3MD00725A ↗

84. Chowdhury MA (2017) Metal‐organic‐frameworks as contrast agents in magnetic resonance imaging. ChemBioEng Rev 4:225–23910.1002/cben.201600027 ↗

85. Rieter WJ, Taylor KM, An H, Lin W, Lin W (2006) Nanoscale metal−organic frameworks as potential multimodal contrast enhancing agents. J Am Chem Soc 128:9024–902510.1021/ja0627444 ↗

86. Bunzen H, Jirak D (2022) Recent advances in metal–organic frameworks for applications in magnetic resonance imaging. ACS Appl Mater Interfaces 14:50445–5046210.1021/acsami.2c10272 ↗

87. Chang Y, Chen M, Fu Z, Lu R, Gao Y, Chen F et al (2023) Building porphyrin-based MOFs on MXenes for ppb-level NO sensing. J Mater Chem A 11:6966–697710.1039/D3TA00072A ↗

88. Jiang Z, Yuan B, Qiu N, Wang Y, Sun L, Wei Z et al (2019) Manganese-zeolitic imidazolate frameworks-90 with high blood circulation stability for MRI-guided tumor therapy. Nano-Micro Lett 11:6110.1007/s40820-019-0292-y ↗

89. Shu F, Lv D, Song X-L, Huang B, Wang C, Yu Y et al (2018) Fabrication of a hyaluronic acid conjugated metal organic framework for targeted drug delivery and magnetic resonance imaging. RSC Adv 8:6581–658910.1039/C7RA12969F ↗

90. Xue C-C, Li M-H, Zhao Y, Zhou J, Hu Y, Cai K-Y et al (2020) Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells. Sci Adv 6:eaax134610.1126/sciadv.aax1346 ↗

91. Zhou T, Wu B, Xing D (2012) Bio-modified Fe3O4 core/Au shell nanoparticles for targeting and multimodal imaging of cancer cells. J Mater Chem 22:470–47710.1039/C1JM13692E ↗

92. Chen S-S, Xu X-F, Deng W-Q, Mao G-J, Hu L, Ouyang J et al (2024) An ATP-responsive ZIF-based NIR fluorescence nanosystem for enhanced chemo-photodynamic therapy of tumors. Nanoscale 16:20617–2062710.1039/D4NR03095H ↗

93. Zhou H, Qi M, Shao J, Li X, Zhou Z, Yang S et al (2021) Tumor micro-environment sensitive 19F-magnetic resonance imaging in vivo. J Magn Magn Mater 518:16743610.1016/j.jmmm.2020.167436 ↗

94. DeKrafft KE, Boyle WS, Burk LM, Zhou OZ, Lin W (2012) Zr-and Hf-based nanoscale metal–organic frameworks as contrast agents for computed tomography. J Mater Chem 22:18139–1814410.1039/c2jm32299d ↗

95. Ou R, Aodeng G, Ai J (2023) Advancements in the application of the Fenton reaction in the cancer microenvironment. Pharmaceutics 15:233710.3390/pharmaceutics15092337 ↗

96. Shen J-J, Xue S-J, Mei Z-H, Li T-T, Li H-F, Zhuang X-F et al (2024) Synthesis, characterization, and efficacy evaluation of a PH-responsive Fe-MOF@ GO composite drug delivery system for the treating colorectal cancer. Heliyon. https://doi.org/10.1016/j.heliyon.2024.e2806610.1016/j.heliyon.2024.e28066 ↗

97. Prasad SB, Shinde A, Srinivasrao DA, Famta P, Shah S, Kolipaka T et al (2025) Metal-organic frameworks as therapeutic chameleons: revolutionizing the cancer therapy employing novel nanoarchitectonics. Asian J Pharm Sci 20:101054

98. Li A, Yang X, Chen J (2021) A novel route to size-controlled MIL-53 (Fe) metal–organic frameworks for combined chemodynamic therapy and chemotherapy for cancer. RSC Adv 11:10540–1054710.1039/D0RA09915E ↗

99. Karimi Alavijeh R, Akhbari K (2020) Biocompatible MIL-101 (Fe) as a smart carrier with high loading potential and sustained release of curcumin. Inorg Chem 59:3570–357810.1021/acs.inorgchem.9b02756 ↗

100. Shano LB, Karthikeyan S, Kennedy LJ, Chinnathambi S, Pandian GN (2024) MOFs for next-generation cancer therapeutics through a biophysical approach—a review. Front Bioeng Biotechnol 12:139780410.3389/fbioe.2024.1397804 ↗