Biocompatible PEGylated vanadium-doped magnetite nano-architectures: enhanced anisotropy for magnetic fluid hyperthermia

1. Mehak RP, Thummer LM (2023) Pandey, surface modified iron-oxide based engineered nanomaterials for hyperthermia therapy of cancer cells. Biotechnol Genet Eng Rev 39:1187–1233. https://doi.org/10.1080/02648725.2023.216937010.1080/02648725.2023.2169370 ↗

2. Ghazi R, Ibrahim TK, Abdul Nasir J, Gai S, Ali G, Boukhris I, Rehman Z (2025) Iron oxide based magnetic nanoparticles for hyperthermia, MRI and drug delivery applications: a review. RSC Adv 15:11587–11616. https://doi.org/10.1039/D5RA00728C10.1039/D5RA00728C ↗

3. Tang Z, Liu Y, He M, Bu W (2019) Chemodynamic therapy: tumour microenvironment‐mediated fenton and fenton‐like reactions. Angewandte Chemie. https://doi.org/10.1002/ange.201805664 (Accessed March 25, 2026)10.1002/ange.201805664 ↗

4. Rosensweig RE (2002) Heating magnetic fluid with alternating magnetic field. J Magn Magn Mater 252:370–374. https://doi.org/10.1016/S0304-8853(02)00706-010.1016/S0304-8853(02)00706-0 ↗

5. Manivasagan P, Joe A, Han H-W, Thambi T, Selvaraj M, Chidambaram K, Kim J, Jang E-S (2022) Recent advances in multifunctional nanomaterials for photothermal-enhanced Fenton-based chemodynamic tumor therapy. Mater Today Bio 13:100197. https://doi.org/10.1016/j.mtbio.2021.10019710.1016/j.mtbio.2021.100197 ↗

6. Gao L, Zhuang J, Nie L, Zhang J, Zhang Y, Gu N, Wang T, Feng J, Yang D, Perrett S, Yan X (2007) Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nat Nanotechnol 2:577–583. https://doi.org/10.1038/nnano.2007.26010.1038/nnano.2007.260 ↗

7. Laurent S, Forge D, Port M, Roch A, Robic C, Vander Elst L, Muller RN (2008) Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem Rev 108:2064–2110. https://doi.org/10.1021/cr068445e10.1021/cr068445e ↗

8. Hergt R, Dutz S, Müller R, Zeisberger M (2006) Magnetic particle hyperthermia: nanoparticle magnetism and materials development for cancer therapy. J Phys Condens Matter 18:S2919. https://doi.org/10.1088/0953-8984/18/38/S2610.1088/0953-8984/18/38/S26 ↗

9. Krishnan KM (2010) Biomedical nanomagnetics: a spin through possibilities in imaging, diagnostics, and therapy. IEEE Trans Magn 46:2523–2558. https://doi.org/10.1109/TMAG.2010.204690710.1109/TMAG.2010.2046907 ↗

10. Bokare AD, Choi W (2014) Review of iron-free Fenton-like systems for activating H2O2 in advanced oxidation processes. J Hazard Mater 275:121–135. https://doi.org/10.1016/j.jhazmat.2014.04.05410.1016/j.jhazmat.2014.04.054 ↗

11. Pignatello JJ, Oliveros E, MacKay A (2006) Full article: advanced oxidation processes for organic contaminant destruction based on the fenton reaction and related chemistry. https://doi.org/10.1080/10643380500326564 (Accessed March 25, 2026)10.1080/10643380500326564 ↗

12. Vilela García D, Parmar J, Zeng Y, Zhao Y, Sánchez S (2016) Graphene-based microbots for toxic heavy metal removal and recovery from water. Nano Lett. https://doi.org/10.1021/acs.nanolett.6b00768 (Accessed March 25, 2026)10.1021/acs.nanolett.6b00768 ↗

13. Lee JH, Huh YM, Jun Y, Seo J, Jang J, Song HT, Kim S, Cho EJ, Yoon HG, Suh JS, Cheon J (2007) Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nat Med 13:95–99. https://doi.org/10.1038/nm146710.1038/nm1467 ↗

14. Cullity BD, Graham CD (2011) Introduction to magnetic materials. Wiley Online Books. https://doi.org/10.1002/9780470386323 (Accessed March 25, 2026)10.1002/9780470386323 ↗

15. Fantechi E, Innocenti C, Zanardelli M, Fittipaldi M, Falvo E, Carbo M, Shullani V, Di Cesare Mannelli L, Ghelardini C, Ferretti AM, Ponti A, Sangregorio C, Ceci P (2014) A smart platform for hyperthermia application in cancer treatment: cobalt-doped ferrite nanoparticles mineralized in human ferritin cages. ACS Nano 8:4705–4719. https://doi.org/10.1021/nn500454n10.1021/nn500454n ↗

16. Wei H, Wang E (2013) Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes. Chem Soc Rev 42:6060–6093. https://doi.org/10.1039/C3CS35486E10.1039/C3CS35486E ↗

17. Carrey J, Mehdaoui B, Respaud M (2011) Simple models for dynamic hysteresis loop calculations of magnetic single-domain nanoparticles: application to magnetic hyperthermia optimization. J Appl Phys. https://pubs.aip.org/aip/jap/article/109/8/083921/929402/Simple-models-for-dynamic-hysteresis-loop (Accessed June 29, 2026)10.1063/1.3551582 ↗

18. Rytov RA, Usov NA (2023) Specific absorption rate of randomly oriented magnetic nanoparticles in a static magnetic field. Beilstein J Nanotechnol 14:485–493. https://doi.org/10.3762/bjnano.14.3910.3762/bjnano.14.39 ↗

19. Torres TE, Valdés DP, Hettler S, Nuñez JM, Rodrigo I, Orue I, García JÁ, Plazaola F, Zysler RD, Lima E, Aguirre MH, Goya GF, Arenal R (2025) Vanadium incorporation in ferrite nanoparticles serves as an electron buffer and anisotropy tuner in catalytic and hyperthermia applications. Nanoscale 17:10205–10218. https://doi.org/10.1039/D4NR04219K10.1039/D4NR04219K ↗

20. Nicholls D (1966) The coordination chemistry of vanadium. Coord Chem Rev 1:379–414. https://doi.org/10.1016/S0010-8545(00)80145-910.1016/S0010-8545(00)80145-9 ↗

21. Sanz-Sagué B, Sáenz- Hernández A, Moreno Maldonado AC, Fuentes-García JA, Nuñez JM, Zegura B, Stern A, Kolosa K, Rozman I, Torres TE, Goya GF (2024) Genotoxicity and heating performance of VxFe3-xO4 nanoparticles in health applications. Chem Biol Interact 394:110977. https://doi.org/10.1016/j.cbi.2024.11097710.1016/j.cbi.2024.110977 ↗

22. Dong Z, Feng L, Hao Y, Chen M, Gao M, Chao Y, Zhao H, Zhu W, Liu J, Liang C, Zhang Q, Liu Z (2018) Synthesis of hollow biomineralized CaCO3 –polydopamine nanoparticles for multimodal imaging-guided cancer photodynamic therapy with reduced skin photosensitivity. J Am Chem Soc 140:2165–2178. https://doi.org/10.1021/jacs.7b1103610.1021/jacs.7b11036 ↗

23. Wang X, Zhong X, Bai L, Xu J, Gong F, Dong Z, Yang Z, Zeng Z, Liu Z, Cheng L (2020) Ultrafine titanium monoxide (TiO1+x) nanorods for enhanced sonodynamic therapy. J Am Chem Soc 142:6527–6537. https://doi.org/10.1021/jacs.9b1022810.1021/jacs.9b10228 ↗

24. Shannon RD (1976) Revised effective ionic radii and systematic studies of interatomic distances in halides and chalcogenides. Acta Crystallogr Sect A 32:751–767. https://doi.org/10.1107/S056773947600155110.1107/S0567739476001551 ↗

25. Sun S, Zeng H, Robinson DB, Raoux S, Rice PM, Wang SX, Li G (2004) Monodisperse mFe2O4 (M = Fe, Co, Mn) nanoparticles. J Am Chem Soc. https://doi.org/10.1021/ja0380852 (Accessed March 25, 2026)10.1021/ja0380852 ↗

26. Park J, An K, Hwang Y, Park JG, Noh HJ, Kim JY, Park JH, Hwang NM, Hyeon T (2004) Ultra-large-scale syntheses of monodisperse nanocrystals. Nat Mater 3:891–895. https://doi.org/10.1038/nmat125110.1038/nmat1251 ↗

27. Massart R (1981) Preparation of aqueous magnetic liquids in alkaline and acidic media. IEEE Trans Magn 17:1247–1248. https://doi.org/10.1109/TMAG.1981.106118810.1109/TMAG.1981.1061188 ↗

28. Jokerst JV, Lobovkina T, Zare RN, Gambhir SS (2011) Nanoparticle PEGylation for imaging and therapy. Nanomedicine 6:715–728. https://doi.org/10.2217/nnm.11.1910.2217/nnm.11.19 ↗

29. Li Z, Sun Q, Gao M (2005) Preparation of water‐soluble magnetite nanocrystals from hydrated ferric salts in 2‐Pyrrolidone: mechanism leading to Fe3O4. Angewandte Chemie Int Ed. https://doi.org/10.1002/anie.200460715 (Accessed March 25, 2026)10.1002/anie.200460715 ↗

30. Zhang Y, Kohler N, Zhang M (2002) Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake. Biomaterials 23:1553–1561. https://doi.org/10.1016/S0142-9612(01)00267-810.1016/S0142-9612(01)00267-8 ↗

31. Lartigue L, Oumzil K, Guari Y, Larionova J, Guérin C, Montero J-L, Barragan-Montero V, Sangregorio C, Caneschi A, Innocenti C, Kalaivani T, Arosio P, Lascialfari A (2009) Water-soluble rhamnose-coated Fe3 O4 nanoparticles. Org Lett 11:2992–2995. https://doi.org/10.1021/ol900949y10.1021/ol900949y ↗

32. Waldron RD (1955) Infrared spectra of ferrites. Phys Rev 99:1727–1735. https://doi.org/10.1103/PhysRev.99.172710.1103/PhysRev.99.1727 ↗

33. Maity D, Agrawal DC (2007) Synthesis of iron oxide nanoparticles under oxidizing environment and their stabilization in aqueous and non-aqueous media. J Magn Magn Mater 308:46–55. https://doi.org/10.1016/j.jmmm.2006.05.00110.1016/j.jmmm.2006.05.001 ↗

34. Nohair M, Aymes D, Perriat P, Gillot B (1995) Infrared spectra-structure correlation study of vanadium-iron spinels and of their oxidation products. Vib Spectrosc 9:181–190. https://doi.org/10.1016/0924-2031(95)00004-E10.1016/0924-2031(95)00004-E ↗

35. Kumar SJ, Prameela P, Rao KS, Kiran JN, Rao KH (2020) Structural and magnetic properties of copper-substituted nickel–zinc nanoparticles prepared by sol-gel method. J Superconduc Novel Magnetism. https://doi.org/10.1007/s10948-019-05407-y (Accessed March 27, 2026)10.1007/s10948-019-05407-y ↗

36. Lu AH (2007) Magnetic nanoparticles: synthesis, protection, functionalization, and application. Angewandte Chemie Int Ed. https://doi.org/10.1002/anie.20060286610.1002/anie.200602866 ↗

37. Langford JI, Wilson AJC (1978) Scherrer after sixty years: a survey and some new results in the determination of crystallite size. J Appl Crystallogr 11:102–113. https://doi.org/10.1107/S002188987801284410.1107/S0021889878012844 ↗

38. Lin M, Fu ZY, Tan HR, Tan JPY, Ng SC, Teo E (2012) Hydrothermal synthesis of CeO2 nanocrystals: Ostwald ripening or oriented attachment? Cryst Growth Des 12:3296–3303. https://doi.org/10.1021/cg300421x10.1021/cg300421x ↗

39. Dávila-Ibáñez AB, Salgueiriño V (2013) Chemical and kinetically controllable nucleation, aggregation-coalescence, and Ostwald ripening processes in the synthesis of magnetic Co–B nanoparticles. J Phys Chem C 117:4859–4865. https://doi.org/10.1021/jp312582z10.1021/jp312582z ↗

40. Wolff A, Hetaba W, Wißbrock M, Löffler S, Mill N, Eckstädt K, Dreyer A, Ennen I, Sewald N, Schattschneider P, Hütten A (2014) Oriented attachment explains cobalt ferrite nanoparticle growth in bioinspired syntheses. Beilstein J Nanotechnol 5:210–218. https://doi.org/10.3762/bjnano.5.2310.3762/bjnano.5.23 ↗

41. Hassanzadeh-Tabrizi SA (2023) Precise calculation of crystallite size of nanomaterials: a review. CoLab. https://colab.ws/articles/10.1016%2Fj.jallcom.2023.171914 (Accessed July 14, 2026)10.1016/j.jallcom.2023.171914 ↗

42. Zhang L, He R, Gu H-C (2006) Oleic acid coating on the monodisperse magnetite nanoparticles. Appl Surf Sci 253:2611–2617. https://doi.org/10.1016/j.apsusc.2006.05.02310.1016/j.apsusc.2006.05.023 ↗

43. Masoudi A, Madaah Hosseini HR, Shokrgozar MA, Ahmadi R, Oghabian MA (2012) The effect of poly(ethylene glycol) coating on colloidal stability of superparamagnetic iron oxide nanoparticles as potential MRI contrast agent. Int J Pharm 433:129–141. https://doi.org/10.1016/j.ijpharm.2012.04.08010.1016/j.ijpharm.2012.04.080 ↗

44. Lu A-H, Salabas EL, Schüth F (2007) Magnetic nanoparticles: synthesis, protection, functionalization, and application. Angew Chem Int Ed 46:1222–1244. https://doi.org/10.1002/anie.20060286610.1002/anie.200602866 ↗

45. Lasheras X, Insausti M, Gil de Muro I, Garaio E, Plazaola F, Moros M, De Matteis L, de la Fuente JM, Lezama L (2016) Chemical synthesis and magnetic properties of monodisperse nickel ferrite nanoparticles for biomedical applications. J Phys Chem C 120:3492–3500. https://doi.org/10.1021/acs.jpcc.5b1021610.1021/acs.jpcc.5b10216 ↗

46. Li Y-S, Church JS, Woodhead AL (2012) Infrared and Raman spectroscopic studies on iron oxide magnetic nano-particles and their surface modifications. J Magn Magn Mater 324:1543–1550. https://doi.org/10.1016/j.jmmm.2011.11.06510.1016/j.jmmm.2011.11.065 ↗

47. Mourdikoudis S, Pallares RM, Thanh NTK (2018) Characterization techniques for nanoparticles: comparison and complementarity upon studying nanoparticle properties. Nanoscale 10:12871–12934. https://doi.org/10.1039/c8nr02278j10.1039/c8nr02278j ↗

48. Radu T, Iacovita C, Benea D, Turcu R (2017) X-ray photoelectron spectroscopic characterization of iron oxide nanoparticles. Appl Surf Sci 405:337–343. https://doi.org/10.1016/j.apsusc.2017.02.00210.1016/j.apsusc.2017.02.002 ↗

49. Pankhurst QA, Connolly J, Jones SK, Dobson J (2003) Applications of magnetic nanoparticles in biomedicine. J Phys D Appl Phys 36:R167. https://doi.org/10.1088/0022-3727/36/13/20110.1088/0022-3727/36/13/201 ↗

50. Cullity BD, Graham CD (2011) Introduction to magnetic materials. John Wiley & Sons

51. Usov NA, Liubimov BY (2012) Dynamics of magnetic nanoparticle in a viscous liquid: Application to magnetic nanoparticle hyperthermia. J Appl Phys. https://pubs.aip.org/aip/jap/article/112/2/023901/992393 (Accessed March 28, 2026)10.1063/1.4737126 ↗

52. Aiswarya Gowri VS, Enoch K, Pati SS, Somasundaram AA (2025) Improved stability and hyperthermia efficiency of PEG-coated magnetite nanoparticles. Results Surf. Interfaces 21:100652. https://doi.org/10.1016/j.rsurfi.2025.10065210.1016/j.rsurfi.2025.100652 ↗

53. Liu NN, Pyatakov AP, Saletsky AM, Zharkov MN, Pyataev NA, Sukhorukov GB (2022) The “field or frequency” dilemma in magnetic hyperthermia: the case of ZnMn ferrite nanoparticles. J Magn Magn Mater 555:169379. https://doi.org/10.1016/j.jmmm.2022.16937910.1016/j.jmmm.2022.169379 ↗

54. Ognjanović M, Bošković M, Stanojković T, Dojčinović BP, Abeykoon AMM, Tomić A, Janković D, Vranješ-D̵urić S, Bozin ES, Antić BV (2025) From structure to function: Zn/Mn-modified maghemite as an advanced nanoplatform for magnetic hyperthermia and radionuclide therapy. ACS Appl Mater Interfaces 17:46836–46849. https://doi.org/10.1021/acsami.5c1243910.1021/acsami.5c12439 ↗

55. Mohapatra J, Xing M, Liu JP (2018) Magnetic and hyperthermia properties of CoxFe3-xO4 nanoparticles synthesized via cation exchange. AIP Adv 8:056725. https://doi.org/10.1063/1.500651510.1063/1.5006515 ↗

56. Olusegun SJ, Osial M, Majkowska-Pilip A, Żelechowska-Matysiak K, Nieciecka D, Krajewski M, Pękała M, Krysinski P (2023) Synthesis and characterization of Sr2+ and Gd3+ doped magnetite nanoparticles for magnetic hyperthermia and drug delivery application. Ceram Int 49:19851–19860. https://doi.org/10.1016/j.ceramint.2023.03.10210.1016/j.ceramint.2023.03.102 ↗

57. Shebha Anandhi J, Antilen Jacob G, Justin Joseyphus R (2020) Factors affecting the heating efficiency of Mn-doped Fe3O4 nanoparticles. J Magn Magn Mater 512:166992. https://doi.org/10.1016/j.jmmm.2020.16699210.1016/j.jmmm.2020.166992 ↗

58. Mohammadi-Aghdam S, Mohammed SA, Sadaka MWM, Abed SH, Mohammadalizadeh M, Shamkhi AF (2025) Tailored manganese ferrite nanoparticles with enhanced magnetic properties for effective hyperthermia cancer therapy. Mater Chem Phys 337:130624. https://doi.org/10.1016/j.matchemphys.2025.13062410.1016/j.matchemphys.2025.130624 ↗

59. Morales Ovalle MA, Raineri M, Vasquez Mansilla M, Winkler EL, Zysler RD, Lima E Jr, Torres TE (2025) Cytotoxic impact of catalytic activity and heating efficiency of manganese ferrite nanoparticles with different particle sizes for magnetic fluid hyperthermia. J Biomed Mater Res B Appl Biomater 113:e35638. https://doi.org/10.1002/jbm.b.3563810.1002/jbm.b.35638 ↗

60. Ma W, Zhan Y, Zhang Y, Mao C, Xie X, Lin Y (2021) The biological applications of DNA nanomaterials: current challenges and future directions. Signal Transduct Target Ther 6:351. https://doi.org/10.1038/s41392-021-00727-910.1038/s41392-021-00727-9 ↗