Aptamer-based biosensors for metal ion and mycotoxin detection: Principles and progress

1. Advances in aptamer screening and aptasensors' detection of heavy metal ions10.1186/s12951-021-00914-4 ↗

2. Spectral interference of heavy metal contamination on spectral signals of moisture content for heavy metal contaminated soils10.1109/TGRS.2019.2946297 ↗

3. Heavy metal stabilization via copyrolysis of comodified vermiculite with municipal sludge/aged refuse: comprehensive analysis of hazards and characteristics of multiple coexisting heavy metals10.1016/j.jhazmat.2024.136325 ↗

4. Water quality degradation due to heavy metal contamination: health impacts and eco-friendly approaches for heavy metal remediation10.3390/toxics11100828 ↗

5. Multimycotoxin determination in grains: a comprehensive study on method validation and assessment of effectiveness of controlled atmosphere storage in preventing mycotoxin contamination10.1021/acs.jafc.1c03208 ↗

6. Aptamer-based biosensors for environmental monitoring10.3389/fchem.2020.00434 ↗

7. Advancing global health surveillance of mycotoxin exposures using minimally invasive sampling techniques: a state-of-the-science review10.1021/acs.est.3c04981 ↗

8. Research progress on ratiometric electrochemical sensing of mycotoxins10.1016/j.jelechem.2022.117115 ↗

9. Heavy metal ions detection using nanomaterials-based aptasensors10.1080/10408347.2022.2115287 ↗

10. Application of nanomaterial modified aptamer-based electrochemical sensor in detection of heavy metal ions10.3390/foods11101404 ↗

11. Aptamer-based electrochemical biosensors: signal transduction mechanisms, application progress, and future trends

12. Advances in aptamer-based biosensors for the detection of foodborne mycotoxins10.3390/molecules29163974 ↗

13. A brief review of aptamer-based biosensors in recent years10.3390/bios15020120 ↗

14. Methods for measuring aptamer-protein equilibria: a review10.1016/j.aca.2010.10.032 ↗

15. Aptamers: the "evolution" of SELEX10.1016/j.ymeth.2016.04.020 ↗

16. G-Quadruplex-Forming aptamers-characteristics, applications, and perspectives10.3390/molecules24203781 ↗

17. Comprehensive analytical comparison of strategies used for small molecule aptamer evaluation10.1021/acs.analchem.5b02102 ↗

18. Small-molecule binding aptamers: selection strategies, characterization, and applications10.3389/fchem.2016.00014 ↗

19. Aptasensors for mycotoxin detection: a review10.1016/j.ab.2021.114156 ↗

20. Metal sensing by DNA10.1021/acs.chemrev.7b00063 ↗

21. Immobilization techniques for aptamers on gold electrodes for the electrochemical detection of proteins: a review10.3390/bios10050045 ↗

22. Zwitterionic polymer coated and aptamer functionalized flexible micro-electrode arrays for in vivo cocaine sensing and electrophysiology10.3390/mi14020323 ↗

23. Using nanomaterials as excellent immobilisation layer for biosensor design10.3390/bios13020192 ↗

24. MXene-based aptasensors: advances, challenges, and prospects10.1016/j.pmatsci.2022.100967 ↗

25. Recent progress in mycotoxins detection based on surface-enhanced raman spectroscopy10.1111/1541-4337.12686 ↗

26. Aptamer-engineered nanomaterials to aid in mycotoxin determination10.1016/j.foodcont.2021.108661 ↗

27. Aptamer-based optical and electrochemical sensors: a review10.3390/chemosensors11120569 ↗

28. A comprehensive review on optical and electrochemical aptasensor for detection of fumonisin B110.3389/fnut.2025.1596673 ↗

29. Nucleic acid aptamer-based biosensors: a review10.3390/biomedicines11123201 ↗

30. DNA nanocage confined DNAzyme for detection of lead ions coupled with CRISPR-Cas12a system10.1016/j.cej.2023.148177 ↗

31. Design strategies for aptamer-based biosensors10.3390/s100504541 ↗

32. Aptamer-based signal amplification strategies coupled with microchips for high-sensitivity bioanalytical applications: a review10.1016/j.aca.2022.339893 ↗

33. Recent advances in multiplex aptasensor detection techniques for food-borne pathogens: a comprehensive review of novel approaches

34. Aptasensor for multiplex detection of antibiotics based on FRET strategy combined with aptamer/graphene oxide complex10.1038/s41598-019-44051-3 ↗

35. Application of multiplexed aptasensors in food contaminants detection10.1021/acssensors.0c01740 ↗

36. Conducting polymer-infused electrospun fibre mat modified by POEGMA brushes as antifouling biointerface10.3390/bios12121143 ↗

37. Hydrophilic antifouling 3D porous MXene/holey graphene nanocomposites for electrochemical determination of dopamine10.1016/j.microc.2022.107713 ↗

38. AI-optimized electrochemical aptasensors for stable, reproducible detection of neurodegenerative diseases, cancer, and coronavirus10.1016/j.heliyon.2024.e41338 ↗

39. A simple label-free aptamer-based electrochemical biosensor for the sensitive detection of C-Reactive proteins10.3390/bios12121180 ↗

40. Aptamers 101: aptamer discovery and in vitro applications in biosensors and separations10.1039/D3SC00439B ↗

41. Effect of chemical modifications on aptamer stability in serum10.1089/nat.2017.0680 ↗

42. Aptasensors and advancement in molecular recognition technology10.1002/admt.202400504 ↗

43. Research progress on aptamer electrochemical biosensors based on signal amplification strategy10.3390/s25144367 ↗

44. DNA sensors for the detection of mercury ions10.3390/bios15050275 ↗

45. Fluorescent aptaswitch for detection of lead ions10.1021/acsabm.2c00368 ↗

46. Rapid and selective electrochemical detection of pb2+ ions using aptamer-conjugated alloy nanoparticles10.1007/s42452-020-03840-6 ↗

47. Visual and ultrasensitive detection of mercury ions based on urease catalysis and responsive photonic crystals10.1016/j.dyepig.2021.109676 ↗

48. Recent advances of metal-organic frameworks as nanozymes for mercury ions detection in environmental samples

49. Design and fabrication of self-calibration colorimetric/fluorescence/SERS tri-modal optical sensor for highly rapid and accurate detection of mercury ions in foods

50. Electrochemical aptasensor based on gold modified thiol graphene as sensing platform and gold-palladium modified zirconium metal-organic frameworks nanozyme as signal enhancer for ultrasensitive detection of mercury ions10.1016/j.jcis.2021.08.055 ↗

51. A flexible label-free electrochemical aptasensor based on target-induced conjunction of two split aptamers and enzyme amplification10.1016/j.snb.2022.131766 ↗

52. In situ fabrication of urchin-like Cu@carbon nanoneedles based aptasensor for ultrasensitive recognition of trace mercury ion10.1016/j.bios.2022.114147 ↗

53. Sensing of mercury ions in Porphyra by Copper @ gold nanoclusters based ratiometric fluorescent aptasensor10.1016/j.foodchem.2020.128694 ↗

54. Ultrasensitive detection of trace Hg2+ by SERS aptasensor based on dual recycling amplification in water environment10.1016/j.jhazmat.2021.126251 ↗

55. Rapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples10.1038/s41551-021-00833-7 ↗

56. A novel liquid crystal assay based on aptazyme-assisted bioprobe for ultra-sensitive monitoring of lead ion10.1016/j.snb.2022.132926 ↗

57. Visual monitoring of lead exposure in children's daily activities with an AuNP-based indicator10.1016/j.snb.2023.134731 ↗

58. Label-free colorimetric biosensor for sensitive detection of lead (II) ion based on aptazyme-amplified oxidase-like activity of MnO2 nanoflowers10.1016/j.bios.2025.117751 ↗

59. Fluorescent starch-based hydrogel with cellulose nanofibrils and carbon dots for simultaneous adsorption and detection of Pb(II)10.1016/j.carbpol.2023.121427 ↗

60. Application of PS2M aptamer as receptor layer for electrochemical detection of lead ions10.3390/bios15010059 ↗

61. Photoelectrochemical biosensor for lead ion determination based on complementary strand aptamers10.1002/jccs.202100142 ↗

62. Simultaneous detection and determination of mercury (II) and lead (II) ions through the achievement of novel functional nucleic acid-based biosensors10.1016/j.bios.2018.05.051 ↗

63. A microfluidic aptamer-based sensor for detection of Mercury(II) and Lead(II) ions in water10.3390/mi12111283 ↗

64. A novel ratiometric electrochemical aptasensor based on M-shaped functional DNA complexes for simultaneous detection of trace lead and mercury ions in series aquatic edible vegetables

65. Dual-target electrochemical DNA sensor for detection of Pb2+ and Hg2+ simultaneously by exonuclease I–assisted recycling signal amplification10.1007/s00604-022-05569-y ↗

66. Dual signal-based electrochemical aptasensor for simultaneous detection of Lead(II) and Mercury(II) in environmental water samples10.1016/j.bios.2022.114280 ↗

67. Simultaneous Hg2+ and Pb2+ detection in water samples using an electrochemical aptasensor with dual signal amplification by exonuclease III and metal-organic frameworks10.1016/j.aca.2024.342800 ↗

68. Electrochemiluminescence aptasensor for multiple determination of Hg2+ and Pb2+ ions by using the MIL-53(Al)@CdTe-PEI modified electrode10.1016/j.aca.2019.11.069 ↗

69. An ultra-sensitive electrochemical aptasensor for simultaneous quantitative detection of Pb2+ and Cd2+ in fruit and vegetable10.1016/j.foodchem.2022.132173 ↗

70. Label-free electrochemical aptasensor based on gold nanoparticles/titanium carbide MXene for lead detection with its reduction peak as index signal10.1007/s42114-023-00652-1 ↗

71. Aptamer assisted simultaneous detection of lead and arsenic in water using a handheld system

72. Highly selective and sensitive detection of cadmium ions by horseradish peroxidase enzyme inhibition using a colorimetric microplate reader and smartphone paper-based analytical device10.1016/j.microc.2021.106940 ↗

73. ZIF-12 @ polypyrrole nanowires for selective detection of cadmium ions in water samples10.1016/j.rechem.2024.101527 ↗

74. Engineering carbon dots with a 18-crown-6 for the fluorescence detection of cadmium ions10.1016/j.jphotochem.2023.114809 ↗

75. A label-free electrochemical detection of cadmium ions using aptamer-based biosensor10.1149/1945-7111/ad8d13 ↗

76. Highly sensitive biosensor based on aptamer and hybridization chain reaction for detection of cadmium ions10.1002/bio.4207 ↗

77. Optical visualization of cadmium ion using a label-free nucleic acid aptamer for recognition10.1080/00032719.2023.2235623 ↗

78. A sensitive aptamer fluorescence anisotropy sensor for Cd(2+) using affinity-enhanced aptamers with phosphorothioate modification10.3390/bios12100887 ↗

79. Competitive fluorescence assay for Cd2+based on aptamer structure-switching10.1016/j.microc.2023.109348 ↗

80. Microscale thermophoresis sensor for Cd2+ using aptamer with tetramethylrhodamine label at an internal site10.1016/j.snb.2023.135102 ↗

81. Robust, reliable and quantitative sensing of aqueous arsenic species by Surface-enhanced Raman Spectroscopy: the crucial role of surface silver ions for good analytical practice10.1016/j.saa.2022.121600 ↗

82. Arsenic detection using surface Plasmon resonance sensor with hydrous ferric oxide layer10.1007/s13320-021-0643-4 ↗

83. Development of methylene blue imprinted silica for detecting arsenic ions in aqueous solution10.4491/eer.2023.440 ↗

84. Arsenic ion assisted core–satellites nano-assembly of gold nanoparticles for its colorimetric determination in water

85. The arsenic-binding aptamer cannot bind arsenic: critical evaluation of aptamer selection and binding10.1021/acs.analchem.9b02789 ↗

86. Arsenic removal from Vietnamese groundwater using the arsenic-binding DNA aptamer10.1021/es902407g ↗

87. A computational investigation of the interaction between As3+ and deoxynucleotides10.1080/08927022.2019.1587761 ↗

88. Low-cost, portable, on-site fluorescent detection of As(III) by a paper-based microfluidic device based on aptamer and smartphone imaging10.1007/s00604-023-05693-3 ↗

89. A portable multi-channel fluorescent paper-based microfluidic chip based on smartphone imaging for simultaneous detection of four heavy metals

90. A novel fluorescent aptasensor for Arsenic(III) detection based on a triple-helix molecular switch10.3390/molecules28052341 ↗

91. pH stability improved electrochemical biosensor based on dopamine/aptamer imprinted polymer modified electrodes for simultaneous detection of four toxic metal ions10.1016/j.foodcont.2024.111099 ↗

92. Glutathione engineered gold nanoparticles-based electrochemical aptasensor for determination of arsenic ions in water, food, and soil samples10.1016/j.jfca.2024.106728 ↗

93. Aptasensors based on graphene field-effect transistors for arsenite detection10.1021/acsanm.2c02711 ↗

94. Dual-mode colorimetric determination of As(III) based on negatively-charged aptamer-mediated aggregation of positively-charged AuNPs10.1016/j.aca.2022.340111 ↗

95. A centrifugal microfluidic system for automated detection of multiple heavy metal ions by aptamer-based colorimetric assay10.1016/j.snb.2023.135210 ↗

96. Ratiometric photothermal detection of silver ions using diimmonium salts10.1016/j.talanta.2022.123296 ↗

97. Label-Free, fast response, and simply operated silver ion detection with a Ti(3)C(2)T(x) MXene field-effect transistor10.1021/acs.analchem.1c01094 ↗

98. Ultrasensitive detection of silver(I) ions based on water-soluble micellized phosphorescent silver nanoclusters co-protected by 1,3-benzenedithiol and triphenylphosphine10.1016/j.snb.2022.132382 ↗

99. Fluorescence anisotropy reduction of an allosteric G-Rich oligonucleotide for specific silver ion and cysteine detection based on the G-Ag(+)-G base pair10.1021/acs.analchem.9b03556 ↗

100. A cobalt-based bifunctional metal organic framework-mediated fluorescent bio-sensing system for the hypersensitive detection of Ag ions through catalytic hairpin assembly10.1039/D2NJ02622H ↗