Astragalus polysaccharide inhibits lipogenesis in HFD-fed mice by suppressing LIPG via upregulation of UDPG
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: Traditional Chinese Medicine Analysis · Lipid metabolism and disorders · Metabolomics and Mass Spectrometry Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (37)
Show source-provided references
1. Cui L, Ma Z, Wang D et al (2022) Ultrasound-assisted extraction, optimization, isolation, and antioxidant activity analysis of flavonoids from Astragalus membranaceus stems and leaves. Ultrason Sonochem 90:10619010.1016/j.ultsonch.2022.106190 ↗
2. Sheik A, Kim K, Varaprasad GL et al (2021) The anti-cancerous activity of adaptogenic herb Astragalus membranaceus. Phytomedicine 91:15369810.1016/j.phymed.2021.153698 ↗
3. An E-K, Zhang W, Kwak M et al (2022) Polysaccharides from Astragalus membranaceus elicit T cell immunity by activation of human peripheral blood dendritic cells. Int J Biol Macromol 223:370–37710.1016/j.ijbiomac.2022.11.048 ↗
4. Chen X, Chen C, Fu X (2022) Hypoglycemic effect of the polysaccharides from Astragalus membranaceus on type 2 diabetic mice based on the “gut microbiota–mucosal barrier.” Food Funct 13(19):10121–1013310.1039/D2FO02300H ↗
5. Chen G, Jiang N, Zheng J et al (2023) Structural characterization and anti-inflammatory activity of polysaccharides from Astragalus membranaceus. Int J Biol Macromol 241:12438610.1016/j.ijbiomac.2023.124386 ↗
6. Ru J, Li P, Wang J et al (2014) TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform 6:1310.1186/1758-2946-6-13 ↗
7. Liu Y, Yu R, Wang X et al (2024) Research progress of the effective active ingredients of Astragalus mongholicus in the treatment of diabetic peripheral neuropathy. Biomed Pharmacother 173:11635010.1016/j.biopha.2024.116350 ↗
8. Piché M-E, Tchernof A, Després J-P (2020) Obesity phenotypes, diabetes, and cardiovascular diseases. Circ Res 126(11):1477–150010.1161/CIRCRESAHA.120.316101 ↗
9. Aron-Wisnewsky J, Warmbrunn MV, Nieuwdorp M et al (2021) Metabolism and metabolic disorders and the microbiome: the intestinal microbiota associated with obesity, lipid metabolism, and metabolic health—pathophysiology and therapeutic strategies. Gastroenterology 160(2):573–59910.1053/j.gastro.2020.10.057 ↗
10. Lv R, Liu X, Zhang Y et al (2023) Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome. Sig Transduct Target Ther 8(1):21810.1038/s41392-023-01496-3 ↗
11. Larsson SC, Spyrou N, Mantzoros CS (2022) Body fatness associations with cancer: evidence from recent epidemiological studies and future directions. Metabolism 137:15532610.1016/j.metabol.2022.155326 ↗
12. Elmaleh-Sachs A, Schwartz JL, Bramante CT et al (2023) Obesity management in adults. JAMA 330:2000–201510.1001/jama.2023.19897 ↗
13. Liu F, Sun L, You G et al (2020) Effects of Astragalus polysaccharide on the solubility and stability of 15 flavonoids. Int J Biol Macromol 143:873–88010.1016/j.ijbiomac.2019.09.148 ↗
14. Yan J, Wang Y, Zhang X et al (2019) Snakegourd root/Astragalus polysaccharide hydrogel preparation and application in 3D printing. Int J Biol Macromol 121:309–31610.1016/j.ijbiomac.2018.10.008 ↗
15. Wan X, Yin Y, Zhou C et al (2022) Polysaccharides derived from Chinese medicinal herbs: a promising choice of vaccine adjuvants. Carbohyd Polym 276:11873910.1016/j.carbpol.2021.118739 ↗
16. Zhong M, Yan Y, Yuan H et al (2022) Astragalus mongholicus polysaccharides ameliorate hepatic lipid accumulation and inflammation as well as modulate gut microbiota in NAFLD rats. Food Funct 13(13):7287–730110.1039/D2FO01009G ↗
17. Wang H, Zhu W, Hong Y et al (2024) Astragalus polysaccharides attenuate chemotherapy-induced immune injury by modulating gut microbiota and polyunsaturated fatty acid metabolism. Phytomedicine 128:15549210.1016/j.phymed.2024.155492 ↗
18. Sha W, Zhao B, Wei H et al (2023) Astragalus polysaccharide ameliorates vascular endothelial dysfunction by stimulating macrophage M2 polarization via potentiating Nrf2/HO-1 signaling pathway. Phytomedicine 112:15466710.1016/j.phymed.2023.154667 ↗
19. Sun S, Yang S, Zhang N et al (2023) Astragalus polysaccharides alleviates cardiac hypertrophy in diabetic cardiomyopathy via inhibiting the BMP10-mediated signaling pathway. Phytomedicine 109:15454310.1016/j.phymed.2022.154543 ↗
20. Lv J, Zhang Y, Tian Z et al (2017) Astragalus polysaccharides protect against dextran sulfate sodium-induced colitis by inhibiting NF-κB activation. Int J Biol Macromol 98:723–72910.1016/j.ijbiomac.2017.02.024 ↗
21. Wang J, An G, Peng X et al (2024) Effects of three Huanglian-derived polysaccharides on the gut microbiome and fecal metabolome of high-fat diet/streptozocin-induced type 2 diabetes mice. Int J Biol Macromol 273:13306010.1016/j.ijbiomac.2024.133060 ↗
22. Ye D, Zhao Q, Ding D et al (2023) Preclinical pharmacokinetics-related pharmacological effects of orally administered polysaccharides from traditional Chinese medicines: a review. Int J Biol Macromol 252:12648410.1016/j.ijbiomac.2023.126484 ↗
23. Ernst J, Bar-Joseph Z (2006) STEM: a tool for the analysis of short time series gene expression data. BMC Bioinformatics 7(1):19110.1186/1471-2105-7-191 ↗
24. Le Lay JE, Du Q, Mehta MB et al (2021) Blocking endothelial lipase with monoclonal antibody MEDI5884 durably increases high density lipoprotein in nonhuman primates and in a phase 1 trial. Sci Transl Med 13(590):eabb060210.1126/scitranslmed.abb0602 ↗
25. Robson A (2021) Blocking endothelial lipase raises HDL-C levels. Nat Rev Cardiol 18:46110.1038/s41569-021-00563-y ↗
26. Chen J, Zhou Y, Liu Z et al (2024) Hepatic glycogenesis antagonizes lipogenesis by blocking S1P via UDPG. Science 383(6684):eadi333210.1126/science.adi3332 ↗
27. Izzo LT, Trefely S, Demetriadou C et al (2023) Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis. Sci Adv 9(18):eadf011510.1126/sciadv.adf0115 ↗
28. Zhao S, Jang C, Liu J et al (2020) Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature 579(7800):586–59110.1038/s41586-020-2101-7 ↗
29. Kivelä AM, Dijkstra MH, Heinonen SE et al (2012) Regulation of endothelial lipase and systemic HDL cholesterol levels by SREBPs and VEGF-A. Atherosclerosis 225(2):335–34010.1016/j.atherosclerosis.2012.09.039 ↗
30. Zheng N, Wang H, Zhu W et al (2024) Astragalus polysaccharide attenuates nonalcoholic fatty liver disease through THDCA in high-fat diet-fed mice. J Ethnopharmacol 320:11740110.1016/j.jep.2023.117401 ↗
31. Ma D, Wu T, Qu Y et al (2023) Astragalus polysaccharide prevents heart failure-induced cachexia by alleviating excessive adipose expenditure in white and brown adipose tissue. Lipids Health Dis 22(1):910.1186/s12944-022-01770-3 ↗
32. Cao Y, Deng B, Zhang S et al (2021) Astragalus polysaccharide regulates brown adipogenic differentiation through miR-1258–5p-modulated cut-like homeobox 1 expression. Acta Biochim Biophys Sin (Shanghai) 53:1713–172210.1093/abbs/gmab151 ↗
33. Schilcher I, Stadler JT, Lechleitner M et al (2021) Endothelial lipase modulates paraoxonase 1 content and arylesterase activity of HDL. Int J Mol Sci 22(2):71910.3390/ijms22020719 ↗
34. Klobučar I, Stadler JT, Klobučar L et al (2023) Associations between endothelial lipase, high-density lipoprotein, and endothelial function differ in healthy volunteers and metabolic syndrome patients. Int J Mol Sci 24(3):207310.3390/ijms24032073 ↗
35. Li X, Ge J, Li Y et al (2021) Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease. Acta Pharm Sin B 11(11):3527–354110.1016/j.apsb.2021.03.018 ↗
36. Ye H, Minhajuddin M, Krug A et al (2021) The hepatic microenvironment uniquely protects leukemia cells through induction of growth and survival pathways mediated by LIPG. Cancer Discov 11(2):500–51910.1158/2159-8290.CD-20-0318 ↗
37. Wei J, Li Y, Xu B et al (2020) Astragalus polysaccharides reverse gefitinib resistance by inhibiting mesenchymal transformation in lung adenocarcinoma cells. Am J Transl Res 12(5):1640–1657