CuO-CNT Nanocomposite/Ionic Liquid Modified Sensor as New Breast Anticancer Approach for Determination of Doxorubicin and 5-Fluorouracil Drugs
Source abstract
Abstract
The amplified voltammetric sensor, a novel approach was used for the determination of two anticancer drugs (doxorubicin and 5-fluorouracil). The novel sensor was fabricated by surface amplification of carbon paste electrode (CPE) with 1-ethyl-3-methylimidazolium tetrafluoroborate (EMITFB) and CuO decorated on single wall carbon nanotubes (CuO-SWCNTs). The EMITFB/CuO-SWCNTs/CPE creates a dramatic improvement in oxidation reaction of doxorubicin in aqueous solution. The main advantages of EMITFB/CuO-SWCNTs/CPE compared with a simple sensor are an increase of about × 3.5 in current and a decrease of about 60 mV in the oxidation potential of doxorubicin. Doxorubicin and 5-fluorouracil can be oxidized at potentials of approximately 680 and 970 mV on EMITFB/CuO-SWCNTs/CPE surface that may be sufficient for the simultaneous determination of drugs in a mixture. Doxorubicin and 5-fluorouracil were observed at detection limits of 6.0 nM and 0.4 μM, respectively, on EMITFB/CuO-SWCNTs/CPE surface. EMITFB/CuO-SWCNTs/CPE was efficiently used in the detection of doxorubicin in injection and serum samples.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Electrochemical sensors and biosensors · Analytical Chemistry and Sensors · Electrochemical Analysis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (36)
Show source-provided references
1. 10.1016/j.mpmed.2007.10.01210.1016/j.mpmed.2007.10.012 ↗
2. British National Formulary, BMJ Group and RPS Publishing, UK (2009).
3. Lippincott Illustrated Reviews: Pharmacology, Wolters Kluwer (2015).
4. 10.1016/j.msec.2016.01.00310.1016/j.msec.2016.01.003 ↗
5. 10.1016/j.jpha.2016.03.00310.1016/j.jpha.2016.03.003 ↗
6. 10.1016/j.electacta.2008.11.01810.1016/j.electacta.2008.11.018 ↗
7. 10.1016/j.jpha.2016.07.00510.1016/j.jpha.2016.07.005 ↗
8. xPharm: The Comprehensive Pharmacology Reference, Elsevier (2008).
9. 10.1039/an995200049510.1039/an9952000495 ↗
10. 10.1080/10408347.2011.58977310.1080/10408347.2011.589773 ↗
11. 10.1016/j.molliq.2012.10.00810.1016/j.molliq.2012.10.008 ↗
12. 10.1016/j.molliq.2012.07.01610.1016/j.molliq.2012.07.016 ↗
13. 10.1021/ac950700010.1021/ac9507000 ↗
14. 10.1016/j.snb.2013.12.09210.1016/j.snb.2013.12.092 ↗
15. 10.1021/ie504438z10.1021/ie504438z ↗
16. 10.1016/j.electacta.2013.12.08610.1016/j.electacta.2013.12.086 ↗
17. 10.1016/j.molliq.2014.02.00110.1016/j.molliq.2014.02.001 ↗
18. 10.1039/AI995320002110.1039/AI9953200021 ↗
19. 10.2174/13862071179522243710.2174/138620711795222437 ↗
20. Gupta · International Juornal of Electrchemical Science · 2015 · 10 · 30310.1016/S1452-3981(23)04994-5 ↗
21. 10.1149/2.0611603jes10.1149/2.0611603jes ↗
22. 10.1016/j.jtice.2017.05.03210.1016/j.jtice.2017.05.032 ↗
23. 10.1016/j.electacta.2004.08.05210.1016/j.electacta.2004.08.052 ↗
24. 10.1016/j.electacta.2014.03.12410.1016/j.electacta.2014.03.124 ↗
25. 10.1080/00032719.2013.85578210.1080/00032719.2013.855782 ↗
26. 10.1016/S0039-9140(01)00656-710.1016/S0039-9140(01)00656-7 ↗
27. 10.1016/j.bioelechem.2005.10.00610.1016/j.bioelechem.2005.10.006 ↗
28. 10.1135/cccc2007139810.1135/cccc20071398 ↗
29. 10.1016/j.molliq.2013.02.00210.1016/j.molliq.2013.02.002 ↗
30. 10.1016/j.snb.2016.02.09410.1016/j.snb.2016.02.094 ↗
31. 10.1016/j.measurement.2016.02.05710.1016/j.measurement.2016.02.057 ↗
32. 10.1016/j.molliq.2014.10.04210.1016/j.molliq.2014.10.042 ↗
33. 10.1016/j.foodchem.2013.07.02010.1016/j.foodchem.2013.07.020 ↗
34. 10.1016/j.molliq.2012.06.02610.1016/j.molliq.2012.06.026 ↗
35. 10.1021/ac60210a00710.1021/ac60210a007 ↗
36. 10.1016/j.foodchem.2014.02.08210.1016/j.foodchem.2014.02.082 ↗