Hydrothermally Synthesized Nickel Oxide Nanosheets for Non-Enzymatic Electrochemical Glucose Detection

A non-enzymatic electrocatalyst, nickel oxide (NiO) nanosheets was developed via a facile hydrothermal approach and further characterized in detail. To harness the potential of NiO nanosheets as a potential electrocatalyst, the hydrothermally synthesized nanosheets were fixed onto the sensor working electrode for glucose sensing application. The NiO nanosheets providing abundance active sites for non-enzymatic glucose detection showed sensitive (1618.4 μ A mM ⁻¹ cm ⁻² ) response in the linear range of 0.25–3.75 mM. The excellent electrocatalytic activity of the NiO modified gold working electrode resulted in a low detection limit (2.5 μ M). Moreover, the sensor selectively detected glucose in the solution containing common interferants such as cholesterol, dopamine, uric acid and ascorbic acid, further makes it highly suitable for non-enzymatic glucose detection in near-real samples.