Highly Sensitive Microbiosensor for Creatinine Based on the Combination of Inactive Polypyrrole with Polyion Complexes
Source abstract
Abstract
Potentiometric creatinine microsensors were fabricated by use of a composite film consisting of polyion complex (PIC), which contains creatinine iminohydrolase (CIH), and the electrochemically inactive polypyrrole (iPPy). The PPy/PIC‐CIH composite film electrode displayed potential response to creatinine concentration owing to a pH change occurring during the enzymatic reaction. The sensitivity was varied by using different polyions of the PIC. With poly‐L‐lysine and sebacic acid, the iPPy/PIC‐CIH electrode demonstrated a high sensitivity (29.8 mV decade −1 ) and a low detection limit , which allow one to monitor creatinine concentration in the physiological range.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Electrochemical sensors and biosensors · Conducting polymers and applications · Analytical Chemistry and Sensors
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Applied Chemistry, School of Science and Engineering, Kagami Memorial Laboratory for Materials Science and Technology, Waseda University, Shinjuku‐ku, Tokyo 169, Japan
References
Reference metadata was not supplied for this record.