journal article·2026-01-01Open access

Preparation of brookite-type titanium dioxide particle layer on titanium surfaces via hydrothermal treatment and evaluation of in vitro apatite-forming ability

Satoshi Hayakawa, Yushi Nakamoto, Seiya Kojima, Noriyuki Nagaoka, Takuya Kataoka, Tomohiko Yoshioka

Abstract

In this study, we prepared a brookite-type titanium dioxide particle layer on the surface of titanium substrates via hydrothermal treatment in aqueous urea solutions containing sodium chloride (NaCl) and examined its in vitro apatite-forming ability.Increasing the urea concentration suppressed the formation of anatase-type titanium dioxide on the titanium substrate, forming a particle layer composed of pure brookite-type titanium dioxide.The size and packing density of brookite-type titanium dioxide particles formed on the titanium substrate increased with the NaCl concentration in a 7.0 moldm -3 urea solution.When titanium substrates hydrothermally treated in aqueous solutions of 7.0 moldm -3 urea and 2.0 moldm -3 NaCl were soaked in a simulated body fluid for various periods up to 7 d, the substrate surface was densely covered with hemispherical apatite particles (5.3 m in diameter) within 3 d, indicating that the brookite-type titanium dioxide particle layer had an excellent apatite-forming ability comparable to that of the anatase-type titanium dioxide particle layer.
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Research context

OpenAlex topics: Bone Tissue Engineering Materials · Titanium Alloys Microstructure and Properties · TiO2 Photocatalysis and Solar Cells

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University

Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University

Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School

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