journal article·2025-09-01Open access

Preparation and structural characterization of nanoporous silica/magnesium(II)-whitlockite composite particles

Takuya Kataoka, Daiki Hirota, Eiji Fujii, Tomohiko Yoshioka, Satoshi Hayakawa

Abstract

The preparation of particles composed of nanoporous silica (NS) and Mg 2+ -whitlockite (Mg-WH) would provide valuable insights for designing particles for biomedical applications.In this study, NS and Mg-WH composite particles were successfully synthesized.The addition of chitosan during synthesis possibly promoted the crystallization of calcium phosphate phases in the composite particles.Pore size distribution analysis of the particles showed a maximum at 3.2 nm.Investigating the adsorption of methylene blue onto the particles in a phosphate buffer (pH 7.4) showed that the saturated adsorption amount of methylene blue on the particles was significantly higher than that on commercial hydroxyapatite.The composite particles provided important results for potential applications as drug carriers for bone regeneration and repair.Key-words:
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Research context

OpenAlex topics: Mesoporous Materials and Catalysis

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Affiliations

Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University

Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University

Industrial Technology Center of Okayama Prefecture

References (26)

Show source-provided references
1. 1) L. S. Mendes, S. Saska, M. A. U. Martines and R. Marchetto, Mat. Sci. Eng. C-Mater. 33, 4427 (2013).10.1016/j.msec.2013.06.040 ↗
2. 2) X. Shi, Y. Wang, L. Ren, N. Zhao, Y. Gong and D. A. Wang, Acta Biomater. 5, 1697 (2009).10.1016/j.actbio.2009.01.010 ↗
3. 3) A. Díaz, T. López, J. Manjarrez, E. Basaldella, J. M. Martínez-Blanes and J. A. Odriozola, Acta Biomater. 2, 173 (2006).10.1016/j.actbio.2005.12.006 ↗
4. 4) S. Yamada, S. Motozuka and M. Tagaya, J. Mater. Chem. B 8, 1524 (2020).10.1039/C9TB02534K ↗
5. 5) M. Zhu, Y. Zhu, B. Ni, N. Xie, X. Lu, J. Shi, Y. Zeng and X. Guo, ACS Appl. Mater. Inter. 6, 5456 (2014).10.1021/am405013t ↗
6. 6) A. Fatemeh, S. T. Arezoo, E. Pedram, P. H. M. Seyyed, E. Farzam, A. A. Kofi and N. Ali, Int. J. Pharm. 625, 122099 (2022).
7. 7) M. Manzano and M. Vallet-Regí, Adv. Funct. Mater. 30, 1902634 (2020).10.1002/adfm.201902634 ↗
8. 8) T. Yanagisawa, T. Shimizu, K. Kuroda and C. Kato, B. Chem. Soc. Jpn. 63, 988 (1990).10.1246/bcsj.63.988 ↗
9. 9) C. T. Kresge, M. E. Leonowicz, W. J. Roth, J. C. Vartuli and J. S. Beck, Nature 359, 710 (1992).10.1038/359710a0 ↗
10. 10) S. Adrian, P. Magdalena, S. Wiesław, M. Dorota and W. Gavin, Micropor. Mesopor. Mat. 274, 113 (2019).
11. 11) L. Jia, J. Shen, Z. Li, D. Zhang, Q. Zhang, C. Duan, G. Liu, D. Zheng, Y. Liu and X. Tian, Int. J. Pharm. 439, 81 (2012).10.1016/j.ijpharm.2012.10.011 ↗
12. 12) Y. Zhang, Z. Zhi, T. Jiang, J. Zhang, Z. Wang and S. Wang, J. Control. Release 145, 257 (2010).10.1016/j.jconrel.2010.04.029 ↗
13. 13) L. Wu, F. Feyerabend, A. F. Schilling, R. Willumeit-Römer and B. J. C. Luthringer, Acta Biomater. 27, 294 (2015).10.1016/j.actbio.2015.08.042 ↗
14. 14) R. Gopal, C. Calvo, J. Ito and W. K. Sabine, Can. J. Chem. 52, 1155 (1974).10.1139/v74-181 ↗
15. 15) H. D. Kim, H. L. Jang, H. Y. Ahn, H. K. Lee, J. Park, E. Lee, E. A. Lee, Y. H. Jeong, D. G. Kim, K. T. Nam and N. S. Hwang, Biomaterials 112, 31 (2017).10.1016/j.biomaterials.2016.10.009 ↗
16. 16) Y. Yang, H. Wang, H. Yang, Y. Zhao, J. Guo, X. Yin, T. Ma, X. Liu and L. Li, ACS Biomater. Sci. Eng. 6, 5785 (2020).10.1021/acsbiomaterials.0c00852 ↗
17. 17) H. L. Jang, G. B. Zheng, J. Park, H. D. Kim, H. R. Baek, H. K. Lee, K. Lee, H. N. Han, C. K. Lee, N. S. Hwang, J. H. Lee and K. T. Nam, Adv. Healthc. Mater. 5, 128 (2016).10.1002/adhm.201400824 ↗
18. 18) S. Brunauer, L. S. Deming, W. E. Deming and E. Teller, J. Am. Chem. Soc. 62, 1723 (1940).10.1021/ja01864a025 ↗
19. 19) Y. Liu, L. Sun, J. Liu, Y. Peng, X. Ge, L. Shi and W. Huang, Dalton T. 44, 237 (2015).10.1039/C4DT02444C ↗
20. 20) I. Izquierdo-Barba, M. Vallet-Regí, N. Kupferschmidt, O. Terasaki, A. Schmidtchen and M. Malmsten, Biomaterials 30, 5729 (2009).10.1016/j.biomaterials.2009.07.003 ↗
21. 21) S. Koutsopoulos, J. Biomed. Mater. Res. 62, 600 (2002).10.1002/jbm.10280 ↗
22. 22) T. Debroise, E. Colombo, G. Belletti, J. Vekeman, Y. Su, R. Papoular, N. S. Hwang, D. Bazin, M. Daudon, P. Quaino and F. Tielens, Cryst. Growth Des. 20, 2553 (2020).10.1021/acs.cgd.9b01679 ↗
23. 23) R. Mathew, P. N. Gunawidjaja, I. Izquierdo-Barba, K. Jansson, A. García, D. Arcos, M. Vallet-Regí and M. Edén, J. Phys. Chem. C 115, 20572 (2011).10.1021/jp206237n ↗
24. 24) A. Kizalaite, V. Klimavicius, V. Balevicius, G. Niaura, A. N. Salak, J. Yang, S. H. Cho, T. Goto, T. Sekino and A. Zarkov, CrystEngComm 25, 4370 (2023).10.1039/D3CE00602F ↗
25. 25) K. Yoshihara, N. Nagaoka, Y. Yoshida, B. Van Meerbeek and S. Hayakawa, Acta Biomater. 97, 544 (2019).10.1016/j.actbio.2019.08.029 ↗
26. 26) M. Ben Osman, S. Diallo-Garcia, V. Herledan, D. Brouri, T. Yoshioka, J. Kubo, Y. Millot and G. Costentin, J. Phys. Chem. C 119, 23008 (2015).10.1021/acs.jpcc.5b08732 ↗