Tri-responsive porous silica carrier with gold nanoparticles for chemophotothermal combination therapy
Source abstract
Abstract
A multifunctional nanoplatform (pSiO2–Au/HA) combining porous silica (pSiO2) carriers and gold nanoparticles (Au NPs) was synthesized for chemophotothermal synergistic therapy. The pSiO2 carrier has the diameter size of 70 nm and high specific surface area (510.8 m2·g−1). Au NPs as photothermal agents and gatekeepers were linked to pSiO2 carriers by Au–S bonds for redox-responsive drug release and photothermal effect. Hyaluronic acid (HA) molecules were conjugated by the amide bonds on the surface of porous silica (pSiO2) to seal the drug-loaded pores and endow it pH-and enzyme-responsive property. The results demonstrated that pSiO2–Au/HA carriers displayed good pH/redox/enzyme-responsive release behavior and photothermal effect, which may be a good promising targeted delivery systems for chemophotothermal therapy.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Gold and Silver Nanoparticles Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (27)
Show source-provided references
1. Mahmoudi M, Sant S, Wang B, Laurent S, Sen T (2011) Adv Drug Deliv Rev 63:24–4610.1016/j.addr.2010.05.006 ↗
2. Zhang Z, Wang J, Chen C (2013) Adv Mater 25:3869–388010.1002/adma.201301890 ↗
3. Zhang X, Wang Y, Zhao Y, Sun L (2017) Mater Sci Eng C 77:19–2610.1016/j.msec.2017.03.224 ↗
4. Jiang W, Mo F, Jin X, Chen L, Xu LJ, Guo L, Fu F (2017) Adv Mater Interfaces 4:170042510.1002/admi.201700425 ↗
5. He H, Zhu R, Sun W, Cai K, Chen Y, Yin L (2018) Nanoscale 10:2856–286510.1039/C7NR07677K ↗
6. Ranji-Burachaloo H, Reyhani A, Gurr PA, Dunstan DE, Qiao GG (2019) Nanoscale 11:5705–571610.1039/C8NR09107B ↗
7. Markeb AA, El-Maali NA, Sayed DM, Osama A, Abdel-Malek MAY, Zaki AH, Elwanis MEA, Driscoll JJ (2016) Int J Breast Cancer 2016:1–810.1155/2016/7549372 ↗
8. Croissant JG, Fatieiev Y, Almalik A, Khashab NM (2018) Adv Healthc Mater 7:170083110.1002/adhm.201700831 ↗
9. Cao N, Zhao Y, Sang B, Wang Z, Cao L, Sun L, Zou X (2016) Mater Sci Eng C 69:330–33610.1016/j.msec.2016.06.096 ↗
10. Cao N, Xie X, Zhang Y, Zhao Y, Cao L, Sun L (2016) J Ind Eng Chem 34:9–1310.1016/j.jiec.2015.10.040 ↗
11. Zhang Q, Guo J, Zhang X, Zhao Y, Cao L, Sun L (2018) Sens Actuators B 276:370–37710.1016/j.snb.2018.08.118 ↗
12. Montoto AH, Montes R, Samadi A, Gorbe M, Terrés JM, Cao-Milán R, Aznar E, Ibañez J, Masot R, Marcos MD, Orzáez M, Sancenón F, Oddershede LB, Martínez-Máñez R (2018) ACS Appl Mater Interfaces 10:27644–2765610.1021/acsami.8b08395 ↗
13. Zhang Z, Wang J, Nie X, Wen T, Ji Y, Wu X, Zhao Y, Chen C (2014) J Am Chem Soc 136:7317–732610.1021/ja412735p ↗
14. Moreira AF, Rodrigues CF, Reis CA, Costa EC, Correia IJ (2018) Microporous Mesoporous Mater 270:168–17910.1016/j.micromeso.2018.05.022 ↗
15. Hu Y, Liu Y, Xie X, Bao W, Hao J (2018) J Colloid Interface Sci 529:547–55510.1016/j.jcis.2018.06.027 ↗
16. Villaverde G, Gómez-Graña S, Guisasola E, García I, Hanske C, Liz-Marzán LM, Baeza A, Vallet-Regí M (2018) Part Part Syst Charact 35:180014810.1002/ppsc.201800148 ↗
17. Poudel BK, Soe ZC, Ruttala HB, Gupta B, Ramasamy T, Thapa RK, Gautam M, Ou W, Nguyen HT, Jeong J-H, Jin SG, Choi H-G, Yong CS, Kim JO (2018) Int J Pharm 548:92–10310.1016/j.ijpharm.2018.06.056 ↗
18. Huang X, Tang S, Mu X, Dai Y, Chen G, Zhou Z, Ruan F, Yang Z, Zheng N (2010) Nat Nanotech 6:28–3210.1038/nnano.2010.235 ↗
19. Yang Y, Lin Y, Di D, Zhang X, Wang D, Zhao Q, Wang S (2017) J Colloid Interface Sci 508:323–33110.1016/j.jcis.2017.08.050 ↗
20. Mattheolabakis G, Milane L, Singh A, Amiji MM (2015) J Drug Target 23:605–61810.3109/1061186X.2015.1052072 ↗
21. Du X, Li X, Huang H, He J, Zhang X (2015) Nanoscale 7:6173–618410.1039/C5NR00640F ↗
22. Tournebize J, Boudier A, Sapin-Minet A, Maincent P, Leroy P, Schneider R (2012) ACS Appl Mater Interfaces 4:5790–579910.1021/am3012752 ↗
23. Qiu L, Zhao Y, Cao N, Cao L, Sun L, Zou X (2016) Sens Actuators B 234:21–2610.1016/j.snb.2016.04.136 ↗
24. Zhang X, Zhao Y, Cao L, Sun L (2018) Sens Actuators B 257:105–11510.1016/j.snb.2017.10.104 ↗
25. Zhou H, Xu H, Li X, Lv Y, Ma T, Guo S, Huang Z, Wang X, Xu P (2017) Mater Sci Eng C 81:261–27010.1016/j.msec.2017.08.002 ↗
26. Rahoui N, Jiang B, Hegazy M, Taloub N, Wang Y, Yu M, Huang YD (2018) Colloids Surf B 171:176–18510.1016/j.colsurfb.2018.07.015 ↗
27. Guo Z, Zheng K, Tan Z, Liu Y, Zhao Z, Zhu G, Ma K, Cui C, Wang L, Kang T (2018) J Mater Chem B 6:7750–775910.1039/C8TB01810C ↗