Multifunctional porous silica nanoparticles for dual responsive drug release
Source abstract
Abstract
Porous silica nanoparticles (PSNs) were prepared by hydrolysis of tetraethyl orthosilicate and 3-aminopropyltriethoxysilane in emulsion. The PSN carriers with hierarchical pores are suitable for loading drug and controlling release. Chitosan molecules were used to close all drug-loaded pores to reduce the premature release. Hyaluronic acid (HA) modified carbon dots (CDHA) are further used to encapsulate carriers, which endow them enzyme responsiveness. The PSN carriers display pH/enzyme-responsive release and the drug release follows the first-order kinetics model. CDHA can be used not only for fluorescent marker for carriers, but also for qualitative monitoring of the drug release.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Carbon and Quantum Dots Applications · Electrochemical sensors and biosensors · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (30)
Show source-provided references
1. Mura S, Nicolas J, Couvreur P (2013) Stimuli-responsive nanocarriers for drug delivery. Nat Mater 12:991–100310.1038/nmat3776 ↗
2. Kumari M, Mondal S, Sharma PK (2019) Synthesis, characterization and electrochemical monitoring of drug release properties of dual stimuli responsive mesoporous GdPO4:Eu3+ nanoparticles. J Alloy Compd 776:654–66510.1016/j.jallcom.2018.10.286 ↗
3. Liu P, Zhang R, Pei M (2017) Design of pH/reduction dual-responsive nanoparticles as drug delivery system for DOX: modulating controlled release behavior with bimodal drug-loading. Colloid Surf B 160:455–46110.1016/j.colsurfb.2017.09.049 ↗
4. Ramasamy T, Haidar Z, Tran TH, Choi J, Jeong JH, Shin BS, Choi HG, Yong CS, Kim JO (2014) Layer-by-layer assembly of liposomal nanoparticles with PEGylated polyelectrolytes enhances systemic delivery of multiple anticancer drugs. Acta Biomater 10:5116–512710.1016/j.actbio.2014.08.021 ↗
5. Qu J, Wang Q-Y, Chen K-L, Luo J-B, Zhou Q-H, Lin J (2018) Reduction/temperature/pH multi-stimuli responsive core cross-linked polypeptide hybrid micelles for triggered and intracellular drug release. Colloid Surf B 170:373–38110.1016/j.colsurfb.2018.06.015 ↗
6. Wei J, Shi J, Wu Q, Yang L, Cao S (2015) Hollow hydroxyapatite/polyelectrolyte hybrid microparticles with controllable size, wall thickness and drug delivery properties. J Mater Chem B 3:8162–816910.1039/C5TB01268F ↗
7. Maiti D, Mukhopadhyay S, Mohanta SC, Saha A, Devi PS (2015) A multifunctional nanocomposite of magnetic g-Fe2O3 and mesoporous fluorescent ZnO. J Alloy Compd 653:187–19410.1016/j.jallcom.2015.08.230 ↗
8. Cao N, Xie X, Zhang Y, Zhao Y, Cao L, Sun L (2016) Dendritic porous SnO2/SiO2@polymer nanospheres for pH-controlled styptic drug release. J Ind Eng Chem 34:9–1310.1016/j.jiec.2015.10.040 ↗
9. Wang C, Li Z, Cao D, Zhao YL, Gaines JW, Bozdemir OA, Ambrogio MW, Frasconi M, Botros YY, Zink JI, Stoddart JF (2012) Stimulated release of size-selected cargos in succession from mesoporous silica nanoparticles. Angew Chem Int Ed 51:5460–546510.1002/anie.201107960 ↗
10. Wang Y, Wang J, Yang Y, Sun Y, Yuan Y, Li Y, Liu C (2018) In situ biodegradable crosslinking of cationic oligomer coating on mesoporous silica nanoparticles for drug delivery. Colloid Surf B 170:373–38110.1016/j.colsurfb.2018.06.021 ↗
11. Wang Y, Nor YA, Song H, Yang Y, Xu C, Yu M, Yu C (2016) Small-sized and large-pore dendritic mesoporous silica nanoparticles enhance antimicrobial enzyme delivery. J Mater Chem B 4:2646–265310.1039/C6TB00053C ↗
12. Liu J, Luo Z, Zhang J, Luo T, Zhou J, Zhao X, Cai K (2016) Hollow mesoporous silica nanoparticles facilitated drug delivery via cascade pH stimuli in tumor microenvironment for tumor therapy. Biomaterials 83:51–6510.1016/j.biomaterials.2016.01.008 ↗
13. Luo Z, Ding X, Hu Y, Wu S, Xiang Y, Zeng Y, Zhang B, Yan H, Zhang H, Zhu L, Liu J, Li J, Cai K, Zhao Y (2013) Engineering a hollow nanocontainer platform with multifunctional molecular machines for tumor-targeted therapy in vitro and in vivo. ACS Nano 7:10271–1028410.1021/nn404676w ↗
14. Du X, Shi B, Tang Y, Dai S, Qiao SZ (2014) Label-free dendrimer-like silica nanohybrids for traceable and controlled gene delivery. Biomaterials 35:5580–559010.1016/j.biomaterials.2014.03.051 ↗
15. Fang Y, Zheng G, Yang J, Tang H, Zhang Y, Kong B, Lv Y, Xu C, Asiri AM, Zi J, Zhang F, Zhao D (2014) Dual-pore mesoporous carbon@silica composite core-shell nanospheres for multidrug delivery. Angew Chem Int Ed 53:5366–537010.1002/anie.201402002 ↗
16. Du X, He J (2011) Hierarchically mesoporous silica nanoparticles: extraction, amino-functionalization, and their multipurpose potentials. Langmuir 27:2972–297910.1021/la200014w ↗
17. Luo L, Liang Y, Erichsen ES, Anwander R (2018) Hierarchical mesoporous organosilica-silica core-shell nanoparticles capable of controlled fungicide release. Chem Eur J 24:7200–720910.1002/chem.201800135 ↗
18. Tan L, Yang M, Wu H, Tang Z, Xiao J, Liu C, Zhuo R (2015) Glucose- and pH-responsive nanogated ensemble based on polymeric network capped mesoporous silica. ACS Appl Mater Interfaces 7:6310–631610.1021/acsami.5b00631 ↗
19. Qiu L, Zhao Y, Cao N, Cao L, Sun L, Zou X (2016) Silver nanoparticle-gated fluorescence porous silica nanospheres for glutathione-responsive drug delivery. Sens Actuators B Chem 234:21–2610.1016/j.snb.2016.04.136 ↗
20. Wang Y, Luo Y, Zhao Q, Wang Z, Xu Z, Jia X (2016) An enzyme-responsive nanogel carrier based on PAMAM dendrimers for drug delivery. ACS Appl Mater Interfaces 8:19899–1990610.1021/acsami.6b05567 ↗
21. Huang L, Liu J, Gao F, Cheng Q, Lu B, Zheng H, Xu H, Xu P, Zhang X, Zeng X (2018) Dual-responsive, hyaluronic acid targeted drug delivery system based on hollow mesoporous silica nanoparticles for cancer therapy. J Mater Chem B 6:4618–462910.1039/C8TB00989A ↗
22. Qiu L, Zhao Y, Li B, Wang Z, Cao L, Sun L (2017) Triple-stimuli (protease/redox/pH) sensitive porous silica nanocarriers for drug delivery. Sens Actuators B Chem 240:1066–107410.1016/j.snb.2016.09.083 ↗
23. Liu J-H, Cao L, LeCroy GE, Wang P, Meziani MJ, Dong Y, Liu Y, Luo P, Sun Y-P (2015) Carbon quantum dots for fluorescence labeling of cells. ACS Appl Mater Interfaces 7:19439–1944510.1021/acsami.5b05665 ↗
24. Yu C, Xuan T, Chen Y, Zhao Z, Liu X, Lian G, Li H (2016) Gadolinium-doped carbon dots with high quantum yield as an effective fluorescence and magnetic resonance bimodal imaging probe. J Alloy Compd 688:611–61910.1016/j.jallcom.2016.07.226 ↗
25. Zhang Q, Guo J, Zhang X, Zhao Y, Cao L, Sun L (2018) Redox-and enzyme-responsive fluorescent porous silica nanocarriers for drug delivery. Sens Actuators B Chem 276:370–37710.1016/j.snb.2018.08.118 ↗
26. Baker SN, Baker GA (2010) Luminescent carbon nanodots: emergent nanolights. Angew Chem Int Ed 49:6726–674410.1002/anie.200906623 ↗
27. Moghaddam SPH, Saikia J, Yazdimamaghani M, Ghandehari H (2017) Redox-responsive polysulfide-based biodegradable organosilica nanoparticles for delivery of bioactive agents. ACS Appl Mater Interfaces 9:21133–2114610.1021/acsami.7b04351 ↗
28. Du X, Shi B, Liang J, Bi J, Dai S, Qiao SZ (2013) Developing functionalized dendrimer-like silica nanoparticles with hierarchical pores as advanced delivery nanocarriers. Adv Mater 25:5981–598510.1002/adma.201302189 ↗
29. Nasab NA, Kumleh HH, Beygzadeh M, Teimourian S, Kazemzad M (2018) Delivery of curcumin by a pH-responsive chitosan mesoporous silica nanoparticles for cancer treatment. Artif Cell Nanomed Biotechnol 46:75–8110.1080/21691401.2017.1290648 ↗
30. Fang C, Zhu Y (2012) Chitosan enclosed mesoporous silica nanoparticles as drug nanocarriers: sensitive response to the narrow pH range. Micropor Mesopor Mat 150:83–8910.1016/j.micromeso.2011.07.023 ↗