Aminosilane as an effective binder for hydroxyapatite-gelatin nanocomposites
Source abstract
Abstract
Aminosilane has been explored as an alternative chemical linker to facilitate the binding and solidification of hydroxyapatite-gelatin nanocomposite at room temperature, which was synthesized using co-precipitation method in the presence of gelatin. This aminosilane treatment was found effective at low concentration (~25 μL/mL) and the solidification and dehydration of hydroxyapatite-gelatin slurry completes within hours depending on the amount of aminosilane. The resulting sample exhibits compressive strength of 133 MPa, about 40% higher than glutaraldehyde treated samples, and shows good biocompatibility based on cell adhesion, proliferation, alkaline phosphate synthesis, and mineralization studies.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Collagen: Extraction and Characterization · Dental Implant Techniques and Outcomes
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (24)
Show source-provided references
1. Green D, Walsh D, Mann S, Oreffo ROC (2002) The potential of biomimesis in bone tissue engineering: lessons from the design and synthesis of invertebrate skeletons. Bone 30:810–81510.1016/S8756-3282(02)00727-5 ↗
2. Boskey AL (1998) Will biomimetics provide new answers for old problems of calcified tissues? Calcif Tissue Int 63:179–18210.1007/s002239900511 ↗
3. Murugan R, Ramakrishna S (2005) Development of nanocomposites for bone grafting. Compos Sci Technol 65:2385–240610.1016/j.compscitech.2005.07.022 ↗
4. Wahl DA, Czernuszka JT (2006) Collagen-hydroxyapatite composites for hard tissue repair. Eur Cell Mater 11:43–5610.22203/eCM.v011a06 ↗
5. Wu TJ, Huang HH, Lan CW, Lin CH, Hsu FY, Wang YJ (2004) Studies on the microspheres comprised of reconstituted collagen and hydroxyapatite. Biomaterials 25:651–65810.1016/S0142-9612(03)00576-3 ↗
6. Chang MC, Ko CC, Douglas WH (2003) Preparation of hydroxyapatite-gelatin nanocomposite. Biomaterials 24:2853–286210.1016/S0142-9612(03)00115-7 ↗
7. Chang MC, Ko CC, Douglas WH (2003) Conformational change of hydroxyapatite/gelatin nanocomposite by glutaraldehyde. Biomaterials 24:3087–309410.1016/S0142-9612(03)00150-9 ↗
8. Chang MC, Ko CC, Douglas WH (2005) Modification of hydroxyapatite/gelatin composite by polyvinylalcohol. J Mater Sci 40:2723–272710.1007/s10853-005-2116-3 ↗
9. Chang MC, Douglas WH (2007) Cross-linkage of hydroxyapatite/gelatin nanocomposite using imide-based zero-length cross-linker. J Mater Sci Mater Med 18:2045–205110.1007/s10856-007-3152-0 ↗
10. Higashi S, Yamamuro T, Nakamura T, Ikada Y, Hyon SH, Jamshidi K (1986) Polymer hydroxyapatite composites for biodegradable bone fillers. Biomaterials 7:183–18710.1016/0142-9612(86)90099-2 ↗
11. Yunos DM, Bretcanu O, Boccaccini AR (2008) Polymer-bioceramic composites for tissue engineering scaffolds. J Mater Sci 43:4433–444210.1007/s10853-008-2552-y ↗
12. Ko CC, Luo TJM, Ma A (2008) Hydroxyapatite/GEMOSIL nanocompsoite. In: Narayan R, Colombo P (eds) Advances in bioceramics and porous ceramics: ceramic engineering and science proceedings. Wiley, New York
13. Rao MS, Dubenko IS, Roy S, Ali N, Dave BC (2001) Matrix-assisted biomimetic assembly of ferritin core analogues in organosilica sol-gels. J Am Chem Soc 123:1511–151210.1021/ja003229n ↗
14. Anderson SI, Downes S, Perry CC, Caballero AM (1998) Evaluation of the osteoblast response to a silica gel in vitro. J Mater Sci Mater Med 9:731–73510.1023/A:1008955002955 ↗
15. Carturan G, Dal Toso R, Boninsegna S, Dal Monte R (2004) Encapsulation of functional cells by sol–gel silica: actual progress and perspectives for cell therapy. J Mater Chem 14:2087–209810.1039/B401450B ↗
16. Dupraz AMP, de Wijn JR, vanderMeer SAT, de Groot K (1996) Characterization of silane-treated hydroxyapatite powders for use as filler in biodegradable composites. J Biomed Mater Res 30:231–23810.1002/(SICI)1097-4636(199602)30:2<231::AID-JBM13>3.0.CO;2-P ↗
17. Parisuthiman D, Mochida Y, Duarte WR, Yamauchi M (2005) Biglycan modulates osteoblast differentiation and matrix mineralization. J Bone Miner Res 20:1878–188610.1359/JBMR.050612 ↗
18. Brinker CJ, Scherer GW (1990) Sol-gel science. Academic Press, San Diego
19. Hench LL, West JK (1990) The sol-gel process. Chem Rev 90:33–7210.1021/cr00099a003 ↗
20. Helbig JM, Hutter M, Schonholzer UP (2000) Lack of syneresis during gelation of dense colloidal suspensions. J Colloid Interf Sci 222:46–5010.1006/jcis.1999.6596 ↗
21. Lana SLB, Seddon AB (1998) X-ray diffraction studies of sol–gel derived ORMOSILs based on combinations of tetramethoxysilane and trimethoxysilane. J Sol-Gel Sci Technol 13:461–46610.1023/A:1008685614559 ↗
22. Sousa RA, Reis RL, Cunha AM, Bevis MJ (2003) Coupling of HDPE/hydroxyapatite composites by silane-based methodologies. J Mater Sci Mater Med 14:475–48710.1023/A:1023471011749 ↗
23. Wang M, Bonfield W (2001) Chemically coupled hydroxyapatite-polyethylene composites: structure and properties. Biomaterials 22:1311–132010.1016/S0142-9612(00)00283-0 ↗
24. Ko CC, Oyen M, FA M, Hu W-S (2006) Mechanical properties and cytochompatibility of biomimetic hydroxyapatite-gelatin nanocomposites. J Mater Res 21:3090–309810.1557/jmr.2006.0394 ↗