Synthesis and characterization of poly(lactic acid)-modified superparamagnetic iron oxide nanoparticles
Source abstract
Abstract
Poly(ethylene glycol) (PEG)- and poly(vinylpyrrolidone) (PVP)-coated superparamagnetic iron oxide nanoparticles (SPIONs) with the particle size of 8.0 ± 1.4 nm were synthesized by thermal decomposition of Fe(acac)3 in 15 g PEG containing 0.3 g PVP (PEG/PVP-SPIONs) and then were coated further with poly(lactic acid) (PLA/PEG/PVP-SPIONs). The PEG/PVP-SPIONs and PLA/PEG/PVP-SPIONs were superparamagnetic with the saturation magnetization of 54.5 and 46.2 emu/g measured by the superconducting quantum interference device, respectively. The hydrodynamic diameter of PEG/PVP-SPIONs in deionized water was 18.8 nm, which increased to 52.4 nm after coated with PLA. The zeta potential of PEG/PVP-SPIONs was 0 mV, which changed to −11.3 mV after coated with PLA. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy analyses indicated that PLA was attached to the PEG/PVP-SPIONs. Thermogravimetric analyses showed that the amount of PLA coated on PEG/PVP-SPIONs was about 9.6 wt%. With high magnetic properties and good dispersibility in aqueous media, the uniform-sized PLA/PEG/PVP-SPIONs nanoparticles have potential in biomedical application. The synthesis and coating of the SPIONs.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Iron oxide chemistry and applications · Magnetic Properties and Synthesis of Ferrites
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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