A pH-sensitive controlled dual-drug release from meso-macroporous silica/multilayer-polyelectrolytes coated SBA-15 composites
Source abstract
Abstract
A novel dual-drug delivery system based on mesoporous-macroporous silica/polyelectrolytes-SBA-15 has been synthesized. The structure and composition of these materials were characterized by powder X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, and N2 adsorption–desorption measurements. In this system, water-soluble metformin hydrochloride and fat-soluble ibuprofen were used as model drugs to study the controlled release behavior. The pH-controlled release of individual drugs was obtained by the primary release of metformin hydrochloride from polyelectrolytes-SBA-15 in acid condition and the predominant release of ibuprofen from MMC in alkaline environment. The results show that the polyelectrolytes-SBA-15/mesoporous-macroporous silica can be used as dual-drug release system and the individual drug can be controlled release with the change of pH value of the environment.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Polymer Surface Interaction Studies · Hydrogels: synthesis, properties, applications · Mesoporous Materials and Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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