Polylactic acid microparticles embedded porous gelatin scaffolds with multifunctional properties for soft tissue engineering
Source abstract
Abstract
Suitable three-dimensional scaffolds showing controllable drug delivery properties, known as multifunctional scaffolds, have gained increasing interest for soft tissue engineering. Here, tetracycline hydrochloride-encapsulated polylactic acid (TCH-PLA) microparticles prepared by using the double emulsion/solvent evaporation method were incorporated into a gelatin matrix. Highly interconnected porous TCH-PLA-in-Gel scaffolds were formed by using lyophilization. In vitro release studies showed that the scaffolds exhibit a controlled release behavior and release low amounts of the drug. TCH-PLA particles additionally reinforced porous gelatin scaffolds and enhanced thermal stability. Antibacterial activity of the scaffolds against Staphylococcus aureus and Escherichia coli was confirmed by using the disk diffusion method. The scaffolds exhibited biocompatibility with adult human dermal fibroblasts, without cytotoxicity. Results indicated that TCH-PLA-in-Gel scaffolds showing multifunctional properties are good candidates for the applications of soft tissue engineering.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Pickering emulsions and particle stabilization · Advanced Drug Delivery Systems · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (31)
Show source-provided references
1. Soft tissue engineering and microbial infections: challenges and perspectives
2. Design and characterization of microcapsules-integrated collagen matrixes as multifunctional three-dimensional scaffolds for soft tissue engineering10.1016/j.jmbbm.2016.05.009 ↗
3. Strategic design and fabrication of biomimetic 3D scaffolds: unique architectures of extracellular matrices for enhanced adipogenesis and soft tissue reconstruction10.1038/s41598-018-23966-3 ↗
4. Osteochondral tissue engineering: scaffolds, stem cells and applications10.1111/j.1582-4934.2012.01571.x ↗
5. Multifunctional scaffolds for bone tissue engineering and in situ drug delivery
6. Soft-matrices based on silk fibroin and alginate for tissue engineering10.1016/j.ijbiomac.2016.04.045 ↗
7. Modeling and optimization of gelatin-chitosan micro-carriers preparation for soft tissue engineering: using response surface methodology10.1016/j.msec.2017.02.108 ↗
8. Elaboration and evaluation of alginate foam scaffolds for soft tissue engineering10.1016/j.ijpharm.2017.02.060 ↗
9. Layer-by-layer assembly of type I collagen and chondroitin sulfate on aminolyzed PU for potential cartilage tissue engineering application10.1016/j.apsusc.2012.06.051 ↗
10. Fabrication of chitosan based hybrid porous scaffolds by salt leaching for soft tissue engineering10.1016/j.surfin.2016.07.005 ↗
11. Facile fabrication of poly(L-lactic acid) microsphere-incorporated calcium alginate/hydroxyapatite porous scaffolds based on Pickering emulsion templates10.1016/j.colsurfb.2016.01.005 ↗
12. Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating10.1116/1.4897217 ↗
13. Covalently antibacterial alginate-chitosan hydrogel dressing integrated gelatin microspheres containing tetracycline hydrochloride for wound healing10.1016/j.msec.2016.08.086 ↗
14. Physical and antibacterial properties of alginate films containing cinnamon bark oil and soybean oil10.1016/j.lwt.2015.05.008 ↗
15. Terbinafine-loaded wound dressing for chronic superficial fungal infections10.1016/j.msec.2016.12.078 ↗
16. Novel soy protein blend scaffolds loaded with antibiotics : drug release profile-bacterial inhibition effects
17. Overview of the preparation of organic polymeric nanoparticles for drug delivery based on gelatine, chitosan, poly(d,l-lactide-co-glycolic acid) and polyalkylcyanoacrylate10.1016/j.colsurfb.2014.03.017 ↗
18. PHEA-PLA biocompatible nanoparticles by technique of solvent evaporation from multiple emulsions10.1016/j.ijpharm.2015.09.050 ↗
19. Encapsulation of the natural antioxidant aureusidin in biodegradable PLA nanoparticles10.1016/j.polymdegradstab.2014.08.004 ↗
20. Nanoparticles and nanofibers for topical drug delivery10.1016/j.jconrel.2015.10.049 ↗
21. Methods for in vitro evaluating antimicrobial activity: a review10.1016/j.jpha.2015.11.005 ↗
22. Alginate-based biomaterials for regenerative medicine applications10.3390/ma6041285 ↗
23. Electrospinning of alginate/soy protein isolated nanofibers and their release characteristics for biomedical applications10.1016/j.jsamd.2017.05.010 ↗
24. Enhanced structural stability and controlled drug release of hydrophilic antibiotic-loaded alginate/soy protein isolate core-sheath fibers for tissue engineering applications10.1007/s12221-019-8753-y ↗
25. Structure and properties of electrospun PLLA single nanofibres10.1088/0957-4484/16/2/005 ↗
26. Development and characterization of coaxially electrospun gelatin coated poly (3-hydroxybutyric acid) thin films as potential scaffolds for skin regeneration10.1016/j.msec.2013.06.042 ↗
27. Thermal decomposition of tetracycline and chlortetracycline10.1016/j.jaap.2016.02.015 ↗
28. Unrestricted somatic stem cells loaded in nanofibrous scaffolds as potential candidate for skin regeneration10.1080/00914037.2013.879447 ↗
29. Preparation and characterization of artificial skin using chitosan and gelatin composites for potential biomedical application10.1007/s00289-012-0761-7 ↗
30. Dual-functional melatonin releasing device loaded with PLGA microparticles and cyclodextrin inclusion complex for osteosarcoma therapy10.1016/j.jddst.2019.05.027 ↗
31. Evaluation of the kinetic and relaxation time of gentamicin sulfate released from hybrid biomaterial Bioglass-chitosan scaffolds10.1016/j.apsusc.2015.06.146 ↗