Synthesis and characterization of a new biomaterial-based scaffold based on chitosan and cashew gum: an inquiry into structural and physical properties

1. K. Zhang, S. Wang, C. Zhou, L. Cheng, X. Gao, X. Xie, J. Sun, H. Wang, M.D. Weir, M.A. Reynolds, N. Zhang, Y. Bai, H.H.K. Xu, Advanced smart biomaterials and constructs for hard tissue engineering and regeneration. Bone Res. 6(1), 31 (2018). https://doi.org/10.1038/s41413-018-0032-910.1038/s41413-018-0032-9 ↗

2. J.-W. Jang, K.-E. Min, C. Kim, J. Shin, J. Lee, S. Yi, Review: scaffold characteristics fabrication methods, and biomaterials for the bone tissue engineering. Int. J. Precis. Eng. Manuf. Smart Tech. 24(3), 511–529 (2023). https://doi.org/10.1007/s12541-022-00755-710.1007/s12541-022-00755-7 ↗

3. M.D. Souza, M.A. Ferreira, C.M. Pompeo, F.M. Mota, E.R. Cury, Transplant management in Brazil: a temporal analysis of financial investments and procedures. Rev. da Esc. de Enferm. da USP (2024). https://doi.org/10.1590/1980-220X-REEUSP-2024-0039en10.1590/1980-220X-REEUSP-2024-0039en ↗

4. L.A. Ramos, T. Schiavo, J. Montagner, C. Bundcher, R. Kist, V.D. Garcia, J. Neumann, E. Keitel, Waiting time for kidney transplantation based on calculated panel reactive antibodies: experience of a southern Brazilian center. J. brasileiro de nefrologia 46(1), 79–84 (2024). https://doi.org/10.1590/2175-8239-JBN-2022-0132en10.1590/2175-8239-JBN-2022-0132en ↗

5. L. Signorini, G. Marenzi, A. Facente, B. Marrelli, R.M. Marano, A. Valletta, L. Pacifici, R. Gasparro, G. Sammartino, M. Severino, Critical overview on pure chitosan-based scaffolds for bone tissue engineering: clinical insights in dentistry. Int. J. Med. Sci. 20(12), 1527–1534 (2023). https://doi.org/10.7150/ijms.8797810.7150/ijms.87978 ↗

6. A.L. Gaspar, A.B. Gaspar, L.R.F. Contini, M.F. Silva, E.G.L. Chagas, J.O. Bahu, V.O.C. Concha, R.A. Carvalho, P. Severino, E.B. Souto, P.S. Lopes, C.M.P. Yoshida, Lemongrass (Cymbopogon citratus)-incorporated chitosan bioactive films for potential skincare applications. Int. J. Pharm. (2022). https://doi.org/10.1016/j.ijpharm.2022.12230110.1016/j.ijpharm.2022.122301 ↗

7. D.P. Valido, W.D.G. Junior, M.E. de Andrade, A.A. Rezende, F.M. de Andrade de Carvalho, R. de Lima, G. das Gracas Gomes Trindade, C. de Alcantara Campos, A.M.S. Oliveira, E. de Souza, L.A. Frank, S.S. Guterres, E.M. Sussuchi, C.R.S. Matos, A. Polloni, A.A. de Souza Araujo, F.F. Padilha, P. Severino, E.B. Souto, R.L.C. de Albuquerque Junior, Otoliths-composed gelatin/sodium alginate scaffolds for bone regeneration. Drug Deliv Transl Res. 10(6): 1716 (2020).https://doi.org/10.1007/s13346-020-00845-x10.1007/s13346-020-00845-x ↗

8. K. Kanimozhi, S. Khaleel Basha, V. Sugantha Kumari, Processing and characterization of chitosan/PVA and methylcellulose porous scaffolds for tissue engineering. Mat. Sci. Eng. C 61, 484 (2016). https://doi.org/10.1016/j.msec.2015.12.08410.1016/j.msec.2015.12.084 ↗

9. A. Kirillova, T.R. Yeazel, D. Asheghali, S.R. Petersen, S. Dort, K. Gall, M.L. Becker, Fabrication of biomedical scaffolds using biodegradable polymers. Chem. Rev. 121(18), 11238 (2021). https://doi.org/10.1021/acs.chemrev.0c0120010.1021/acs.chemrev.0c01200 ↗

10. J.A. Ataide, E.F. Gerios, L.C. Cefali, A.R. Fernandes, M.D.C. Teixeira, N.R. Ferreira, E.B. Tambourgi, A.F. Jozala, M.V. Chaud, L. Oliveira-Nascimento, P.G. Mazzola, E.B. Souto, Effect of polysaccharide sources on the physicochemical properties of bromelain-chitosan nanoparticles. Polymers 11(10), 1681 (2019). https://doi.org/10.3390/polym1110168110.3390/polym11101681 ↗

11. P. Hissae Yassue-Cordeiro, C.H. Zandonai, B. Pereira Genesi, P. Santos Lopes, E. Sanchez-Lopez, M.L. Garcia, N.R. Camargo Fernandes-Machado, P. Severino, B.S. E, C. Ferreira da Silva, Development of Chitosan/silver sulfadiazine/zeolite composite films for wound dressing. Pharmaceutics 11(10), 535 (2019). https://doi.org/10.3390/pharmaceutics1110053510.3390/pharmaceutics11100535 ↗

12. H.S. Debone, P.S. Lopes, P. Severino, C.M.P. Yoshida, E.B. Souto, C.F. da Silva, Chitosan/Copaiba oleoresin films for would dressing application. Int. J. Pharm. 555, 146 (2019). https://doi.org/10.1016/j.ijpharm.2018.11.05410.1016/j.ijpharm.2018.11.054 ↗

13. C. Ferreira da Silva, P. Severino, F. Martins, M.H. Santana, E.B. Souto, Didanosine-loaded chitosan microspheres optimized by surface-response methodology: a modified ‘“maximum likelihood classification”’ approach formulation for reverse transcriptase inhibitors. Biomed. Pharma. 70, 46 (2015). https://doi.org/10.1016/j.biopha.2014.12.04710.1016/j.biopha.2014.12.047 ↗

14. S. Jose, M.T. Prema, A.J. Chacko, A.C. Thomas, E.B. Souto, Colon specific chitosan microspheres for chronotherapy of chronic stable angina. Coll. Surf. B Biointerf. 83(2), 277 (2011). https://doi.org/10.1016/j.colsurfb.2010.11.03310.1016/j.colsurfb.2010.11.033 ↗

15. S. Kumari, R. Kishor, Chitin and chitosan: origin, properties, and applications in S Gopi, S Thomas, A Pius (eds) Handbook of Chitin and Chitosan (Elsevier) Ch 1 p1–33, in: S. Gopi, S. Thomas, A. Pius (Eds.), Handbook of Chitin and Chitosan, Elsevier2020, pp. 1–33.10.1016/B978-0-12-817970-3.00001-8 ↗

16. A.D. Gholap, S. Rojekar, H.S. Kapare, N. Vishwakarma, S. Raikwar, A. Garkal, T.A. Mehta, H. Jadhav, M.K. Prajapati, U. Annapure, Chitosan scaffolds: expanding horizons in biomedical applications. Carbohyd. Polym. 323, 121394 (2024). https://doi.org/10.1016/j.carbpol.2023.12139410.1016/j.carbpol.2023.121394 ↗

17. H. Hemmami, G. Ben Amor, S. Bayzid, M. Maamir, N. Gherbi, Z. Chourouk, A. Alnazza Alhamad, Chitosan as a tissue engineering scaffold. IJS Global Health (2024). https://doi.org/10.1097/GH9.000000000000030210.1097/GH9.0000000000000302 ↗

18. L. Andrea, I. Marica, R. Anamarija, Lysozyme-induced degradation of chitosan: the characterisation of degraded chitosan scaffolds. J. Tissue Rep. Regenerat. 1(1), 12–22 (2017). https://doi.org/10.14302/issn.2640-6403.jtrr-17-184010.14302/issn.2640-6403.jtrr-17-1840 ↗

19. R.G. Amaral, L.R.M. de Andrade, L.N. Andrade, K.C. Loureiro, E.B. Souto, P. Severino, Cashew gum: a review of brazilian patents and pharmaceutical applications with a special focus on nanoparticles. Micromachines 13(7), 1137 (2022). https://doi.org/10.3390/mi1307113710.3390/mi13071137 ↗

20. K.C. Loureiro, A. Jäger, E. Pavlova, I.B. Lima-Verde, P. Štěpánek, L.S. Sangenito, A.L.S. Santos, M.V. Chaud, H.S. Barud, F. La Mônica, R. Soares, R.L.C. de Albuquerque-Júnior, J.C. Cardoso, E.B. Souto, M. da Costa, P.S. Mendonça, cashew gum (anacardium occidentale) as a potential source for the production of tocopherol-loaded nanoparticles: formulation. Rel Profile Cytotox. Appl. Sci. 11(18), 8467 (2021). https://doi.org/10.3390/app1118846710.3390/app11188467 ↗

21. R.V.D.B. Fernandes, D.A. Botrel, E.K. Silva, S.V. Borges, C. Rodrigues, M. de Oliveira, I. Yoshida, J. Pessoa, de Andrade Feitosa, Regina Célia Monteiro de Paula, Cashew gum and inulin: new alternative for ginger essential oil microencapsulation. Carbohydrate Polym. Technol. Appl. 153, 133 (2016). https://doi.org/10.1016/j.carbpol.2016.07.09610.1016/j.carbpol.2016.07.096 ↗

22. G.V. Schirato, F.M.F. Monteiro, F. De Oliveira, J.L. Silva, D.L. Filho, A.M.D.A.C. Leão, A.L.F. Porto, O polissacarídeo do anacardium occidentale L. na fase inflamatória do processo cicatricial de lesões cutâneas. Ciênc Rural. 36, 149 (2006). https://doi.org/10.1590/S0103-8478200600010002210.1590/S0103-84782006000100022 ↗

23. Y.K.C. Leite, A.C.J. Oliveira, P.V. Quelemes, N.M.A. Neto, C.E.S. Carvalho, H.W. Soares Rodrigues, M.M.M. Alves, F.A.A. Carvalho, D.D.R. Arcanjo, E.C.D. Silva-Filho, A. Durazzo, M. Lucarini, M.A.M. Carvalho, D.A.D. Silva, J. Leite, Novel scaffold based on chitosan hydrogels/phthalated cashew gum for supporting human dental pulp stem cells. Pharmaceuticals (Basel, Switzerland) 16(2), 266 (2023). https://doi.org/10.3390/ph1602026610.3390/ph16020266 ↗

24. J.S. Maciel, S. Azevedo, C.R. Correia, A.M.S. Costa, R.R. Costa, F.A. Magalhães, A.A. de Sousa Monteiro, J.F.G. Costa, R.C.M. de Paula, J.P.A. Feitosa, J.F. Mano, Oxidized cashew gum scaffolds for tissue engineering. Macromol. Mat. Eng. 304(3), 1800574 (2019). https://doi.org/10.1002/mame.20180057410.1002/mame.201800574 ↗

25. C.R. Do, N. Ferreira, E.L. De, L. Ramos, F.S. Luis, L.M. Araujo, D.S. Sousa, P.A. Judith, A.F. Feitosa, M.B. Cunha, J.F. Oliveira, J.D. Mano, S. Maciel, Synthesis and characterization of scaffolds produced under mild conditions based on oxidized cashew gums and carboxyethyl chitosan. Int. J. Biol. Macromol. 176, 26–36 (2021). https://doi.org/10.1016/j.ijbiomac.2021.01.17810.1016/j.ijbiomac.2021.01.178 ↗

26. C.N. Silva, M. da Silva, C.B. Di-Medeiros, L.M. Lião, K.F. Fernandes, K. de Aleluia, Batista, Cashew gum polysaccharide nanoparticles grafted with polypropylene glycol as carriers for diclofenac sodium. Materials (Basel) 14(9), 2115 (2021). https://doi.org/10.3390/ma1409211510.3390/ma14092115 ↗

27. C.N.S. Silva, M.V. Cruz, K.F. Fernandes, K.A. Batista, Production of anti-inflammatory films based on cashew gum polysaccharide and polyvinyl alcohol for wound dressing applications. 3 Biotech 13(9), 299 (2023). https://doi.org/10.1007/s13205-023-03686-w10.1007/s13205-023-03686-w ↗

28. I.M.S. Araújo, M.F. Zampa, J.B. Moura, J.R. dos Santos, P. Eaton, V. Zucolotto, L.M.C. Veras, R.C.M. de Paula, J.P.A. Feitosa, J.R.S.A. Leite, C. Eiras, Contribution of the cashew gum (Anacardium occidentale L) for development of layer-by-layer films with potential application in nanobiomedical devices. Mat. Sci. Eng. C 32(6), 1588–1593 (2012). https://doi.org/10.1016/j.msec.2012.04.04810.1016/j.msec.2012.04.048 ↗

29. S.B.A. Barros, C.M.D.S. Leite, A.C.F. De Brito, J.R. Dos Santos Júnior, V. Zucolotto, C. Eiras, Multilayer films electrodes consisted of cashew gum and polyaniline assembled by the layer-by-layer technique: electrochemical characterization and its use for dopamine determination. Int. J. Anal. Chem. 2012(1), 923208 (2012). https://doi.org/10.1155/2012/92320810.1155/2012/923208 ↗

30. M.A. Oliveira, M.L.C. Gonzaga, M.S.R. Bastos, H.C.R. Magalhães, S.D. Benevides, R.F. Furtado, R.A. Zambelli, D.S. Garruti, Packaging with cashew gum/gelatin/essential oil for bread: Release potential of the citral. Food Packag. Shelf Life 23, 100431 (2020). https://doi.org/10.1016/j.fpsl.2019.10043110.1016/j.fpsl.2019.100431 ↗

31. A. Surendren, N.S. Cheekuramelli, R.P. Magisetty, Biodegradable polymer blends for tissue engineering, in: "Biodegradable Polymers, Blends and Composites", Mavinkere Rangappa, Sanjay; Parameswaranpillai, Jyotishkumar; Siengchin, Suchart; Ramesh, M. (Editors), woodhead publishing, sawston, Cambridge, UK, Chapter 12, pp. 591–609., in: S. Mavinkere Rangappa, J. Parameswaranpillai, S. Siengchin, M. Ramesh (Eds.), Biodegradable Polymers, blends and composites, Woodhead Publishing2022, pp. 591–609.10.1016/B978-0-12-823791-5.00022-3 ↗

32. M. Krishani, W.Y. Shin, H. Suhaimi, N.S. Sambudi, Development of scaffolds from bio-based natural materials for tissue regeneration applications: a review. Gels (Basel, Switzerland) 9(2), 100 (2023). https://doi.org/10.3390/gels902010010.3390/gels9020100 ↗

33. N.J. van Eck, L. Waltman, Software survey: vosviewer, a computer program for bibliometric mapping. Scientometrics 84(2), 523 (2010). https://doi.org/10.1007/s11192-009-0146-310.1007/s11192-009-0146-3 ↗

34. J.F. Rodrigues, C.R.M. de Paula, S.M.O. Costa, Métodos de isolamento de gomas naturais: Comparação através da goma do cajueiro (Anacardium occidentale L.), Polímeros Ciência e Tecnologia 3 31–36 (1993).https://revistapolimeros.org.br/article/588371337f8c9d0a0c8b479c

35. O. Trott, A.J. Olson, AutoDock vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J. Comput. Chem. 31(2), 455 (2010). https://doi.org/10.1002/jcc.2133410.1002/jcc.21334 ↗

36. A.B. Barros, A.F. Moura, D.A. Silva, T.M. Oliveira, F.S. Barreto, W.L.C. Ribeiro, A. Alves, A.J. Araújo, M.O. Moraes Filho, B. Iles, J.V.R. Medeiros, J.D.B. Marinho-Filho, Evaluation of antitumor potential of cashew gum extracted from Anacardium occidentale Linn. Int. J. Biol. Macromol. 154(319), 328 (2020). https://doi.org/10.1016/j.ijbiomac.2020.03.09610.1016/j.ijbiomac.2020.03.096 ↗

37. G.M. Morris, R. Huey, W. Lindstrom, M.F. Sanner, R.K. Belew, D.S. Goodsell, A.J. Olson, AutoDock4 and autodocktools4: automated docking with selective receptor flexibility. J. Comput. Chem. 30(16), 2785 (2009). https://doi.org/10.1002/jcc.2125610.1002/jcc.21256 ↗

38. Y. Zhang, C. Xue, Y. Xue, R. Gao, X. Zhang, Determination of the degree of deacetylation of chitin and chitosan by X-ray powder diffraction. Carbohyd. Res. 340(11), 1914 (2005). https://doi.org/10.1016/j.carres.2005.05.00510.1016/j.carres.2005.05.005 ↗

39. S.M. Dadou, M.I. El-Barghouthi, S.K. Alabdallah, A.A. Badwan, M.D. Antonijevic, B.Z. Chowdhry, Effect of protonation state and n-acetylation of chitosan on its interaction with xanthan gum: a molecular dynamics simulation study. Mar. Drugs 15(10), 298 (2017). https://doi.org/10.3390/md1510029810.3390/md15100298 ↗

40. M.A. Morgano, C.G. Faria, M.F. Ferrão, N. Bragagnolo, M.M.C. Ferreira, Determination of protein in raw coffee for NIR spectroscopy and regression PLS. Food Sci. Technol. 25, 25 (2005). https://doi.org/10.1590/S0101-2061200500010000510.1590/S0101-20612005000100005 ↗

41. K. Naseer, S. Ali, J. Qazi, ATR-FTIR spectroscopy as the future of diagnostics: a systematic review of the approach using bio-fluids. Appl. Spectrosc. Rev. 56(2), 85 (2021). https://doi.org/10.1080/05704928.2020.173845310.1080/05704928.2020.1738453 ↗

42. K. Meera, K. Arun, M.T. Ramesan, Nanochitosan reinforced polyvinyl alcohol/cashew gum bio-blend nanocomposites: promising materials for future frontiers. J. Environ. Polym. Degrad. 31(10), 4487–4505 (2023). https://doi.org/10.1007/s10924-023-02909-810.1007/s10924-023-02909-8 ↗

43. C.G. Mothé, J.S. de Freitas, Thermal behavior of cashew gum by simultaneous TG/DTG/DSC-FT-IR and EDXRF. J. Therm. Anal. Calorim. 116(3), 1509–1514 (2014). https://doi.org/10.1007/s10973-014-3788-110.1007/s10973-014-3788-1 ↗

44. M.A. Fosu, K. Ofori-Kwakye, N. Kuntworbe, M.A. Bonsu, Investigation of blends of cashew and xanthan gums as a potential carrier for colonic delivery of Ibuprofen. Int. J. PharmTech. Res. 9, 369–380 (2016)

45. H. Hamedfar, T. Zivari-Ghader, A. Akbarzadeh, S. Davaran, Physicochemical characteristics of chitosan-alginate scaffold containing atorvastatin. Adv. Polymer. Technol. 2023(1), 9452164 (2023). https://doi.org/10.1155/2023/945216410.1155/2023/9452164 ↗

46. D.A. da Silva, J.P.A. Feitosa, H.C.B. Paula, R.C.M. de Paula, Synthesis and characterization of cashew gum/acrylic acid nanoparticles. Mat. Sci. Eng. C 29(2), 437 (2009). https://doi.org/10.1016/j.msec.2008.08.02910.1016/j.msec.2008.08.029 ↗

47. W.S. Vedakumari, P. Prabu, T.P. Sastry, Chitosan-fibrin nanocomposites as drug delivering and wound healing materials. J. Biomed. Nanotechnol. 11(4), 657 (2015). https://doi.org/10.1166/jbn.2015.194810.1166/jbn.2015.1948 ↗

48. X. Dong, Q. Cheng, Y. Long, C. Xu, H. Fang, Y. Chen, H. Dai, A chitosan based scaffold with enhanced mechanical and biocompatible performance for biomedical applications. Polymer Degrad. Stability 181, 109322 (2020). https://doi.org/10.1016/j.polymdegradstab.2020.10932210.1016/j.polymdegradstab.2020.109322 ↗

49. J. Drzeżdżon, D. Jacewicz, A. Sielicka, L. Chmurzyński, Characterization of polymers based on differential scanning calorimetry based techniques. TrAC Trends Anal. Chem. 110, 51 (2019). https://doi.org/10.1016/j.trac.2018.10.03710.1016/j.trac.2018.10.037 ↗

50. C.G. Mothé, M.A. Rao, Thermal behavior of gum arabic in comparison with cashew gum. Thermochim. Acta 357–358, 9 (2000). https://doi.org/10.1016/S0040-6031(00)00358-010.1016/S0040-6031(00)00358-0 ↗

51. J. Sutharsan, C.A. Boyer, J. Zhao, Physicochemical properties of chitosan edible films incorporated with different classes of flavonoids. Carbohydr. Polym. Technol. Appl. 4, 100232 (2022). https://doi.org/10.1016/j.carpta.2022.10023210.1016/j.carpta.2022.100232 ↗

52. E.O. Olorunsola, P.G. Bhatia, B.A. Tytler, M.U. Adikwu, Thermochemical properties of hydrophilic polymers from cashew and khaya exudates and their implications on drug delivery. J. Drug Deliv. 2016(1), 7496585 (2016). https://doi.org/10.1155/2016/749658510.1155/2016/7496585 ↗

53. M.G. Chuc-Gamboa, R.F. Vargas-Coronado, J.M. Cervantes-Uc, J.V. Cauich-Rodríguez, D.M. Escobar-García, A. Pozos-Guillén, J. San Román del Barrio, The effect of PEGDE concentration and temperature on physicochemical and biological properties of chitosan. Polymers 11(11), 1830 (2019). https://doi.org/10.3390/polym1111183010.3390/polym11111830 ↗

54. G. Lutzweiler, A. Ndreu Halili, N. Engin Vrana, The overview of porous bioactive scaffolds as instructive biomaterials for tissue regeneration and their clinical translation. Pharmaceutics (2020). https://doi.org/10.3390/pharmaceutics1207060210.3390/pharmaceutics12070602 ↗

55. R.M. Isa, M. Jaafar, Z. Ahmad, B.H. Yahya, Effect of chitosan concentration on the properties of PLA/β-TCP scaffold produced by combination of solvent casting and salt leaching techniques. J. Phy. Confer. Ser. 1082(1), 012073 (2018). https://doi.org/10.1088/1742-6596/1082/1/01207310.1088/1742-6596/1082/1/012073 ↗