pH-responsive magnetic mesoporous silica based bimodal drug delivery system for both anionic and cationic drugs
Source abstract
Abstract
In this study, pH-responsive drug delivery system was prepared by magnetic mesoporous silica synthesis through hydrothermal method followed by post-synthetic amino modification. The structure of the synthesized nanocomposite was characterized by XRD, FT-IR, VSM, XPS, TEM, SEM, N2-adsorption/desorption, and surface charge density analyses. The nanocomposite, which was determined to have a remarkably stable mesostructure and superparamagnetic character, was used as drug carrier for both anionic character Indomethacin (IND) and cationic character Doxorubicin (DOX). IND, an anti-inflammatory drug, and DOX, an anticancer drug used in chemotherapy, must be used in high doses due to their low water solubility and lack of targeting ability, respectively. The loading capacities determined according to the adsorption equilibrium are quite high for both drugs (106.96 and 134.10 mg/g, for IND and DOX, respectively) due to electrostatic attraction and hydrogen bond formation. For IND, the release study was realized in phosphate buffer solutions (pH 7.4, 6.8 and 2.2) by mimicking the gastrointestinal tract; for DOX, human blood pH (7.4) and cancer cell pH (5.5) were selected as the release medium. IND exhibited increased release behavior at neutral pH (7.4, 39.5% release), while DOX exhibited increased release behavior at acidic pH (5.5, 39.7% release). Peppas-Sahlin and Korsmeyer-Peppas kinetic models effectively described the IND and DOX release behavior from the nanocomposite. Both IND and DOX could be loaded with high loading efficiency (85.36% and 88.88% for IND and DOX, respectively) onto the nanocomposite and pH-controlled release can be achieved, which may be inspiring for a bimodal nanomedical treatment approach.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Mesoporous Materials and Catalysis · Chemical Synthesis and Characterization · Nanomaterials for catalytic reactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (63)
Show source-provided references
1. L. Karthikeyan, S. Sobhana, V. Yasothamani, K. Gowsalya, R. Vivek, Biomed. Eng. Adv. 5, 100082 (2023). https://doi.org/10.1016/j.bea.2023.10008210.1016/j.bea.2023.100082 ↗
2. B. Yu, R. Shi, X. Chen, Y. Zhang, J. Hu, S. Khan, Inorg. Chem. Commun. 150, 110469 (2023). https://doi.org/10.1016/j.inoche.2023.11046910.1016/j.inoche.2023.110469 ↗
3. L. Hu, C. Sun, A. Song, D. Chang, X. Zheng, Y. Gao, T. Jiang, S. Wang, Asian. J. Pharm. Sci. 9, 183–190 (2014). https://doi.org/10.1016/j.ajps.2014.05.00410.1016/j.ajps.2014.05.004 ↗
4. Y. Wang, F. Li, J. Xin, J. Xu, G. Yu, Q. Shi, Molecules 28, 3406 (2023). https://doi.org/10.3390/molecules2808340610.3390/molecules28083406 ↗
5. N.H. Ferreira, A.B. Ribeiro, F. Rinaldi-Neto, F.S. Fernandes, S. do Nascimento, W.R. Braz, E.J. Nassar, D.C. Tavares, Pharm. Res. 37, 172 (2020). https://doi.org/10.1007/s11095-020-02903-y10.1007/s11095-020-02903-y ↗
6. S. Mohanan, X. Guan, M. Liang, A. Karakoti, A. Vinu, Small 20, 2301113 (2024). https://doi.org/10.1002/smll.20230111310.1002/smll.202301113 ↗
7. A. Martín, V. Morales, J. Ortiz-Bustos, M. Pérez-Garnes, L.F. Bautista, R.A. García-Muñoz, R. Sanz, Micropor. Mesopor. Mater. 262, 23–34 (2018). https://doi.org/10.1016/j.micromeso.2017.11.00910.1016/j.micromeso.2017.11.009 ↗
8. J. Pang, Y. Luan, X. Yang, Y. Jiang, L. Zhao, Y. Zong, Z. Li, Mini-Rev. Med. Chem. 12, 775–788 (2012). https://doi.org/10.2174/13895571280126485510.2174/138955712801264855 ↗
9. G.R. Mahdavinia, H. Hoseinzadeh, P. Labib, P. Jabbari, A. Mohebbi, S. Barzeger, H. Jafari, Polym. Bull. 80, 12923–12943 (2023). https://doi.org/10.1007/s00289-023-04688-710.1007/s00289-023-04688-7 ↗
10. S. Alinavaz, P. Jabbari, G.R. Mahdavinia, H. Jafari, S. Sharifi, Z.M. Lighvan, A. Akbari, Polym. Int. 71, 1243–1251 (2022). https://doi.org/10.1002/pi.640810.1002/pi.6408 ↗
11. K.C. Souza, J.D. Ardisson, E.M.B. Sousa, J. Mater. Sci. Mater. Med. 20, 507–512 (2009). https://doi.org/10.1007/s10856-008-3592-110.1007/s10856-008-3592-1 ↗
12. N.I. Cuello, V.R. Elías, S.N. Mendieta, M. Longhi, M.E. Crivello, M.I. Oliva, G.A. Eimer, Mater. Sci. Eng. C 78, 674–681 (2017). https://doi.org/10.1016/j.msec.2017.02.01010.1016/j.msec.2017.02.010 ↗
13. A.K.H. Nejad, H.A. Panahi, E. Keshmirizadeh, N.T. Fard, Int. J. Polym. Mater. Polym. Biomater. 72, 1083–1092 (2023). https://doi.org/10.1080/00914037.2022.208242410.1080/00914037.2022.2082424 ↗
14. S. Yin, L. Cai, X. Li, K. Lin, X. Shi, H. Zhang, L. Wang, J. Li, Eur. J. Pharm. Sci. 195, 106719 (2024). https://doi.org/10.1016/j.ejps.2024.10671910.1016/j.ejps.2024.106719 ↗
15. V. Zeleňák, D. Halamová, A. Zeleňáková, V. Girman, J. Porous Mater. 23, 1633–1645 (2016). https://doi.org/10.1007/s10934-016-0224-x10.1007/s10934-016-0224-x ↗
16. M. Rasekh, C. Karavasili, Y.L. Soong, N. Bouropoulos, M. Morris, D. Armitage, X. Li, D.G. Fatouros, Z. Ahmad, Int. J. Pharm. 473, 95–104 (2014). https://doi.org/10.1016/j.ijpharm.2014.06.05910.1016/j.ijpharm.2014.06.059 ↗
17. W. Zhang, N. Zheng, L. Chen, L. Xie, M. Cui, S. Li, L. Xu, Pharmaceutics 11, 4 (2019). https://doi.org/10.3390/pharmaceutics1101000410.3390/pharmaceutics11010004 ↗
18. T.J. Dening, D. Zemlyanov, L.S. Taylor, J. Control. Release 307, 186–199 (2019). https://doi.org/10.1016/j.jconrel.2019.06.02810.1016/j.jconrel.2019.06.028 ↗
19. R. Dumitru, A. Ianculescu, C. Pacurariu, L. Lupa, A. Pop, B. Vasile, A. Surdu, F. Manea, Ceram. Int. 45, 2789–2802 (2019). https://doi.org/10.1016/j.ceramint.2018.07.29810.1016/j.ceramint.2018.07.298 ↗
20. D.E. Curry, K.A. Andrea, A.J. Carrier, C. Nganou, H. Scheller, D. Yang, B. Youden, Y. Zhang, A. Nicholson, S. Cui, K.D. Oakes, S.L. MacQuarrie, M. Lu, X. Zhang, Environ. Sci. NANO 5, 1027–1035 (2018). https://doi.org/10.1039/C7EN01171G10.1039/C7EN01171G ↗
21. S. Ehsanimehr, P.N. Moghadam, W. Dehaen, V. Shafiei-Irannejad, Colloids Surf A Physicochem Eng Asp 615, 126302 (2021). https://doi.org/10.1016/j.colsurfa.2021.12630210.1016/j.colsurfa.2021.126302 ↗
22. J. Wang, S. Zheng, Y. Shao, J. Liu, Z. Xu, D. Zhu, J. Colloid Interface Sci. 349, 293–299 (2010). https://doi.org/10.1016/j.jcis.2010.05.01010.1016/j.jcis.2010.05.010 ↗
23. A.J. Szalai, N. Manivannan, G. Kaptay, Colloids Surf. A 568, 113–122 (2019). https://doi.org/10.1016/j.colsurfa.2019.02.00610.1016/j.colsurfa.2019.02.006 ↗
24. Y. Dong, B. Lu, S. Zang, J. Zhao, X. Wang, Q. Cai, J. Chem. Technol. Biotechnol. 86, 616–619 (2011). https://doi.org/10.1002/jctb.255910.1002/jctb.2559 ↗
25. A. Salis, D.F. Parsons, M. Boström, L. Medda, B. Barse, B.W. Ninham, M. Monduzzi, Langmuir 26, 2484–2490 (2010). https://doi.org/10.1021/la902721a10.1021/la902721a ↗
26. H. Kanniyappan, J. Jose, S. Chakraborty, M. Ramasamy, V. Muthuvijayan, J. Aust. Ceram. Soc. 59, 207–220 (2023). https://doi.org/10.1007/s41779-022-00827-x10.1007/s41779-022-00827-x ↗
27. Q.Z. Zhai, Y. Dong, H. Liu, Q.S. Wang, Desalin. Water Treat. 158, 330–342 (2019). https://doi.org/10.5004/dwt.2019.2422910.5004/dwt.2019.24229 ↗
28. D.L. Huber, Small 1, 482–501 (2005). https://doi.org/10.1002/smll.20050000610.1002/smll.200500006 ↗
29. Y. Ye, D. Li, P. Xu, J. Sun, Inorg. Chem. Front. 7, 3636–3645 (2020). https://doi.org/10.1039/D0QI00703J10.1039/D0QI00703J ↗
30. S. Singh, T.D. Nguyen, T.J. Siang, P.T.T. Phuong, N.H.H. Phuc, Q.D. Truong, S.S. Lam, D.V.N. Vo, J. Energy Inst. 93, 31–42 (2020). https://doi.org/10.1016/j.joei.2019.04.01110.1016/j.joei.2019.04.011 ↗
31. P. Bilalis, L.A. Tziveleka, S. Varlas, H. Iatrou, Polym. Chem. 7, 1475–1485 (2016). https://doi.org/10.1039/c5py01841b10.1039/c5py01841b ↗
32. B. Soltani, H. Nabipour, N.A. Nasab, J. Disper, Sci Technol. 39, 1200–1207 (2018). https://doi.org/10.1080/01932691.2017.138817810.1080/01932691.2017.1388178 ↗
33. F. Hassanzadeh-Afruzi, Z. Amiri-Khamakani, M. Saeidirad, M.M. Salehi, R. Taheri-Ledari, A. Maleki, RSC Adv. 13, 10367–10378 (2023). https://doi.org/10.1039/d2ra07228a10.1039/d2ra07228a ↗
34. S.A.M.K. Ansari, E. Ficiara, F.A. Ruffinatti, I. Stura, M. Argenziano, O. Abollino, R. Cavalli, C. Guiot, F. D’Agata, Materials 12, 465 (2019). https://doi.org/10.3390/ma1203046510.3390/ma12030465 ↗
35. J. Dulinska-Litewka, A. Lazarczyk, P. Halubiec, O. Szafranski, K. Karnas, A. Karewicz, Materials 12, 617 (2019). https://doi.org/10.3390/ma1204061710.3390/ma12040617 ↗
36. M. Akkoç, N. Buğday, S. Altın, I. Özdemir, S. Yaşar, Catal. Lett. 152, 1621–1638 (2022). https://doi.org/10.1007/s10562-021-03755-w10.1007/s10562-021-03755-w ↗
37. L. Meng, Y. Chan, H. Wang, Y. Dai, X. Wang, J. Zou, Environ. Sci. Pollut. Res. 23, 5122–5133 (2016). https://doi.org/10.1007/s11356-015-5742-610.1007/s11356-015-5742-6 ↗
38. H. Li, H. Jin, R. Li, J. Hua, Z. Zhang, R. Li, Sci. Rep. 14, 1217 (2024). https://doi.org/10.1038/s41598-023-50368-x10.1038/s41598-023-50368-x ↗
39. D. Bhuyan, M. Saikia, L. Saikia, Catal. Commun. 58, 158–163 (2015). https://doi.org/10.1016/j.catcom.2014.09.01110.1016/j.catcom.2014.09.011 ↗
40. W.A. Talavera-Pech, A. Esparza-Ruiz, P. Quintana-Owen, A.R. Vilchis-Nestor, C. Carrera-Figueiras, A. Avila-Ortega, J. Sol-Gel Sci. Technol. 80, 697–708 (2016). https://doi.org/10.1007/s10971-016-4163-410.1007/s10971-016-4163-4 ↗
41. N.V. Mdlovu, K.S. Lin, M.T. Weng, Y.S. Lin, S.Y. Liu, Colloids Surf B Biointerfaces 220, 112923 (2022). https://doi.org/10.1016/j.colsurfb.2022.11292310.1016/j.colsurfb.2022.112923 ↗
42. Y. Xu, C. Wang, G. Zhou, Y. Wu, J. Chen, Appl. Surf. Sci. 258, 6366–6372 (2012). https://doi.org/10.1016/j.apsusc.2012.03.04110.1016/j.apsusc.2012.03.041 ↗
43. W. Sheng, W. Wei, J. Li, X. Qi, G. Zuo, Q. Chen, X. Pan, W. Dong, Appl. Surf. Sci. 387, 1116–1124 (2016). https://doi.org/10.1016/j.apsusc.2016.07.06110.1016/j.apsusc.2016.07.061 ↗
44. V. Nairi, L. Medda, M. Monduzzi, A. Salis, J. Colloid Interface Sci. 497, 217–225 (2017). https://doi.org/10.1016/j.jcis.2017.03.02110.1016/j.jcis.2017.03.021 ↗
45. H. Hosseinzadeh, Z. Jahanbakhsh, B. Masoumi, V. Hooshangi, Arab. J. Sci. Eng. 49, 459–473 (2024). https://doi.org/10.1007/s13369-023-08202-z10.1007/s13369-023-08202-z ↗
46. A.H. Khalbas, T.M. Albayati, I.K. Salih, N.M.C. Saady, S. Zendehboudi, Arab. J. Sci. Eng. (2025). https://doi.org/10.1007/s13369-025-10087-z10.1007/s13369-025-10087-z ↗
47. B. Tzankov, K. Yoncheva, M. Popova, A. Szegedi, G. Momekov, J. Mihály, N. Lambov, Micropor. Mesopor. Mater. 171, 131–138 (2013). https://doi.org/10.1016/j.micromeso.2012.12.03710.1016/j.micromeso.2012.12.037 ↗
48. C.A. McCarthy, D.Y. Zemlyanov, A.M. Crean, L.S. Taylor, Mol. Pharm. 17, 3062–3074 (2020). https://doi.org/10.1021/acs.molpharmaceut.0c0048910.1021/acs.molpharmaceut.0c00489 ↗
49. S. Kayal, R.V. Ramanujan, Mater. Sci. Eng. C 30, 484–490 (2010). https://doi.org/10.1016/j.msec.2010.01.00610.1016/j.msec.2010.01.006 ↗
50. R. Bansal, R. Singh, K. Kaur, BMC Chem. 15, 27 (2021). https://doi.org/10.1186/s13065-021-00752-310.1186/s13065-021-00752-3 ↗
51. N.V. Roik, L.A. Belyakova, M.O. Dziazko, Adsorpt. Sci. Technol. 35, 86–101 (2017). https://doi.org/10.1177/026361741666950410.1177/0263617416669504 ↗
52. W. Pon-On, N. Charoenphandhu, I.M. Tang, P. Jongwattanapisan, N. Krishnamra, R. Hoonsawat, Mater. Chem. Phys. 131, 485–494 (2011). https://doi.org/10.1016/j.matchemphys.2011.10.00810.1016/j.matchemphys.2011.10.008 ↗
53. S. Mekkapat, B. Thong-On, B. Rutnakornpituk, U. Wichai, M. Rutnakornpituk, J. Nanopart. Res. 15, 2051 (2013). https://doi.org/10.1007/s11051-013-2051-110.1007/s11051-013-2051-1 ↗
54. A.A. Badawi, H.M. El-Laithy, R.K. El Qidra, H. El Mofty, M. El Dally, Arch. Pharm. Res. 31, 1040–1049 (2008). https://doi.org/10.1007/s12272-001-1266-610.1007/s12272-001-1266-6 ↗
55. F. Salari-Goharizi, M. Mahani, H. Sepehrian, M. Yoosefian, F. Khakbaz, J. Porous Mater. 32, 1027–1038 (2025). https://doi.org/10.1007/s10934-025-01752-710.1007/s10934-025-01752-7 ↗
56. M. Ghobadi, S. Salehi, M.T.S. Ardestani, M. Mousavi-Khattat, Z. Shakeran, A. Khosravi, M. Cordani, A. Zarrabi, Eur. J. Pharm. Biopharm. 201, 114349 (2024). https://doi.org/10.1016/j.ejpb.2024.11434910.1016/j.ejpb.2024.114349 ↗
57. N.A. Aval, J.P. Islamian, M. Hatamian, M. Arabfirouzjaei, J. Javadpour, M.R. Rashidi, Int. J. Pharm. 509, 159–167 (2016). https://doi.org/10.1016/j.ijpharm.2016.05.04610.1016/j.ijpharm.2016.05.046 ↗
58. J. Wu, W. Jiang, Y. Shen, W. Jiang, R. Tian, Mater. Sci. Eng. C 70, 132–140 (2017). https://doi.org/10.1016/j.msec.2016.08.05410.1016/j.msec.2016.08.054 ↗
59. B. Yu, R. Shi, C. Liu, Z. Liu, P. Shen, J. Hu, F. Shi, Heliyon 9, e13705 (2023). https://doi.org/10.1016/j.heliyon.2023.e1370510.1016/j.heliyon.2023.e13705 ↗
60. X. Cai, N. Wu, F. Song, H. Luo, T. Li, Y. Yan, S. Li, Y. Li, J. Porous Mater. 31, 1305–1319 (2024). https://doi.org/10.1007/s10934-024-01588-710.1007/s10934-024-01588-7 ↗
61. M.P. Paarakh, P.A. Jose, C.M. Setty, G.V.P. Christoper, IJPRT 8, 12–20 (2018). https://doi.org/10.31838/ijprt/08.01.0210.31838/ijprt/08.01.02 ↗
62. Y. Zhang, M. Huo, J. Zhou, A. Zou, W. Li, C. Yao, S. Xie, AAPS J. 12, 263–271 (2010). https://doi.org/10.1208/s12248-010-9185-110.1208/s12248-010-9185-1 ↗
63. S. Ünal, O. Doğan, Y. Aktaş, J. Fac. Pharm. Ankara 46, 1009–1029 (2022). https://doi.org/10.33483/jfpau.116123810.33483/jfpau.1161238 ↗