Infrared Spectra of the Thymidine 13 C2 and 13 C4 Isotopes in H 2 O and D 2 O
Source abstract
Abstract
Here we report the synthesis of two new 13 C thymidine (T) isotopes labeled at two key positions in its structure, C2═O and C4═O, and the first IR spectra of each T isotope in H 2 O and in D 2 O. Our experimental isotope shifts and normal mode calculations indicate some structurally sensitive modes may be more localized than previously thought, making them regiosensitive probes of thymidine’s chemical environment. These results provide new physical insight into the normal modes of thymidine, and will guide future studies to determine how these structurally and environmentally sensitive probe vibrations are impacted by the duplex environment.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Molecular spectroscopy and chirality · Advanced Chemical Physics Studies · Molecular Spectroscopy and Structure
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Wentworth Institute of Technology
Department of Chemistry and Biochemistry
The University of Texas at Dallas
Organic Chemistry, University of Innsbruck (CCB), Innrain 80/82, 6020 Innsbruck, Austria
Department of Chemistry and Biochemistry, The University of Texas at Arlington, 700 Planetarium Place, Arlington, Texas 76019-0065, United States
Department of Chemistry and Chemical Biology, Institute for Quantitative Biomedicine
Rutgers University
Central Laser Facility, Research Complex at Harwell
STFC Rutherford Appleton Laboratory
Funding
Welch Foundation
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