DataVXThe Journal of Physical Chemistry LettersPaper
journal article·2026-03-26

In Situ Light-Triggered Synthesis of NIR-II Nanoprobes for Deep-Tissue Optical Imaging and Hepatic Photodistribution Mapping

Zhiming Deng, Quan Shen, Yao Huang, Lei Li, Lei Zheng, Jiansheng Dong, Jiayou Tao, Xingwang Wen

The Journal of Physical Chemistry Letters· Volume 17· Issue 12
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Source abstract

Abstract

Accurate assessment of light distribution within the body, particularly in deep tissues, is essential for early disease diagnosis and the advancement of light-based therapeutic strategies. The liver, as a central organ governing metabolism, detoxification, immunity, and coagulation, plays a vital role in maintaining physiological homeostasis. However, noninvasive visualization of light distribution in the liver remains a significant challenge. Herein, we report a strategy for imaging spatial light distribution in liver tissues using second-near-infrared (NIR-II) fluorescence imaging, enabled by specially designed photosensitive AgBr nanocrystals. Upon illumination with smartphone-emitted light, these nanocrystals undergo decomposition, generating Ag 2 S quantum dots that emit in the NIR-II window. Following surface modification with PLGA, the AgBr nanocrystals were administered in vivo, allowing for the real-time visualization of light distribution within hepatic tissue and successful mapping of illumination patterns. This light-activated in situ synthesis of NIR-II-emitting nanoprobes offers a promising approach for the precise diagnosis of deep-tissue pathologies, therapeutic monitoring, and image-guided surgery.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Optical Imaging and Spectroscopy Techniques · Photoacoustic and Ultrasonic Imaging

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Hunan Province on Information Photonics and Freespace Optical Communications, School of physics and electrical sciences

Hunan Institute of Science and Technology

State Key Laboratory for Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering

Hunan University

Department of Physics

Jishou University

Microelectronics and Optoelectronics Technology Key Laboratory of Hunan Higher Education, School of Physics and Electronic Electrical Engineering

Xiangnan University

Department of Pathology, the First Affiliated Hospital, Hengyang Medical School

University of South China

Department of Chemistry

Shantou University

Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology

Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences

Funding

Scientific Research Foundation of Hunan Provincial Education Department · China Postdoctoral Science Foundation · Science and Technology Program of Hunan Province · National Natural Science Foundation of China

References (28)

Show source-provided references
1. 10.1038/s41551-024-01275-710.1038/s41551-024-01275-7 ↗
2. 10.1016/j.matt.2023.06.00910.1016/j.matt.2023.06.009 ↗
3. 10.1021/acs.accounts.3c0049510.1021/acs.accounts.3c00495 ↗
4. 10.1038/s41551-024-01210-w10.1038/s41551-024-01210-w ↗
5. 10.1038/s41551-022-00982-310.1038/s41551-022-00982-3 ↗
6. 10.1002/anie.20230506210.1002/anie.202305062 ↗
7. 10.1039/C8NR00305J10.1039/C8NR00305J ↗
8. 10.1021/acs.nanolett.7b0210610.1021/acs.nanolett.7b02106 ↗
9. 10.1021/acs.nanolett.5c0471810.1021/acs.nanolett.5c04718 ↗
10. 10.1038/s41551-019-0494-010.1038/s41551-019-0494-0 ↗
11. 10.1038/s41565-018-0221-010.1038/s41565-018-0221-0 ↗
12. 10.1038/s41565-023-01501-410.1038/s41565-023-01501-4 ↗
13. 10.1002/adma.20220347710.1002/adma.202203477 ↗
14. 10.1038/s41467-023-36813-510.1038/s41467-023-36813-5 ↗
15. 10.1002/anie.20221272110.1002/anie.202212721 ↗
16. 10.1021/jacs.6b0897310.1021/jacs.6b08973 ↗
17. 10.1038/s41565-018-0221-010.1038/s41565-018-0221-0 ↗
18. 10.1038/s41566-019-0437-z10.1038/s41566-019-0437-z ↗
19. 10.1016/j.cej.2022.13950410.1016/j.cej.2022.139504 ↗
20. 10.1007/s11426-020-9723-910.1007/s11426-020-9723-9 ↗
21. 10.1016/j.actbio.2022.07.04510.1016/j.actbio.2022.07.045 ↗
22. 10.1021/acs.nanolett.1c0207810.1021/acs.nanolett.1c02078 ↗
23. 10.1021/acs.nanolett.4c0552510.1021/acs.nanolett.4c05525 ↗
24. 10.1021/acsnano.0c0979910.1021/acsnano.0c09799 ↗
25. 10.1021/acs.chemrev.4c0083510.1021/acs.chemrev.4c00835 ↗
26. 10.1021/acs.nanolett.5c0053910.1021/acs.nanolett.5c00539 ↗
27. 10.1002/adma.20090434610.1002/adma.200904346 ↗
28. 10.1038/s41551-020-0569-y10.1038/s41551-020-0569-y ↗