DataVXThe Journal of Physical Chemistry LettersPaper
journal article·2024-03-21

Structurally Dynamic Monocyte–Liposome Hybrid Vesicles as an Anticancer Drug Delivery Vehicle: A Crucial Correlation of Microscopic Elasticity and Ultrafast Dynamics

Ria Ghosh, Lopamudra Roy, Dipanjan Mukherjee, Sushmita Sarker, Jayanta Mondal, Nivedita Pan, Md. Nur Hasan, Subhajit Ghosh, Arpita Chattopadhyay, Arghya Adhikary, Maitree Bhattacharyya, Asim Kumar Mallick, Ranjit Biswas, Ranjan Das, Samir Kumar Pal

The Journal of Physical Chemistry Letters· Volume 15· Issue 11
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Source abstract

Abstract

A biomimetic cell-based carrier system based on monocyte membranes and liposomes has been designed to create a hybrid "Monocyte-LP" which inherits the surface antigens of the monocytes along with the drug encapsulation property of the liposome. Förster resonance energy transfer (FRET) and polarization gated anisotropy measurements show the stiffness of the vesicles obtained from monocyte membranes (Mons), phosphatidylcholine membranes (LP), and Monocyte-LP to follow an increasing order of Mons > Monocyte-LP > LP. The dynamics of interface bound water molecules plays a key role in the elasticity of the vesicles, which in turn imparts higher delivery efficacy to the hybrid Monocyte-LP for a model anticancer drug doxorubicin than the other two vesicles, indicating a critical balance between flexibility and rigidity for an efficient cellular uptake. The present work provides insight on the influence of elasticity of delivery vehicles for enhanced drug delivery.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Lipid Membrane Structure and Behavior · Nanoparticle-Based Drug Delivery · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biochemistry, University of Calcutta 35 Ballygunge Circular Road, Ballygunge, Kolkata 700019, India

Department of Chemical and Biological Sciences, S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata 700106, India

Department of Applied Optics and Photonics, University of Calcutta, Block-JD, Sector-III, Saltlake, Kolkata 700106, India

Centre for Research in Nanoscience and Nanotechnology, University of Calcutta, Salt Lake, Kolkata 700106, India

Department of Life Science & Biotechnology, Jadavpur University, 188, Raja Subodh Chandra Mallick Rd, Jadavpur, Kolkata, West Bengal 700032, India

Department of Basic science and Humanities, Techno International New Town Block, DG 1/1, Action Area 1, New Town, Rajarhat, Kolkata 700156, India

Department of Paediatric Medicine, Nil RatanSircar Medical College & Hospital, 138, AJC Bose Road, Sealdah, Raja Bazar, Kolkata 700014, India

Department of Chemistry, West Bengal State University, Barasat, Kolkata 700126, India

Technical Research Centre, S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake, Kolkata, West Bengal 700106, India

Funding

Indian National Academy of Engineering

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