journal article·2024-05-30

Surface-Enhanced Raman Spectroscopy: from the Few-Analyte Limit to Hot-Spot Saturation

Oara Neumann, Jingyi Zhou, Yilong Ju, Mary M. Bajomo, Andrés B. Sánchez-Alvarado, Julia Dolive, Beniam Kumela, Mattie Kumela, Ankit Patel, Peter Nordlander, Naomi J. Halas

The Journal of Physical Chemistry C· Volume 128· Issue 21
Publisher page

Abstract

Surface-enhanced Raman spectroscopy (SERS) gained much attention following initial claims and subsequent verifications of single-molecule sensitivity. SERS substrates based on plasmonic nanoparticles in close proximity create “hot spots” when illuminated, which, in the single-molecule limit, follow log–normal statistics for molecular occupancy. Here, we rigorously examine the transition from the single-molecule limit to the limit of hot spot saturation, a regime that follows Gaussian statistics, by varying a 1:1 bianalyte concentration over 3 orders of magnitude. The bianalyte model is extended here to follow this transition, and the electromagnetic “hot spots” of both Au nanoparticle and Au nanoshells-based SERS substrates are described theoretically. This combined experimental-theoretical study provides a rigorous foundation for quantifying trace analyte detection over a wider and highly practical concentration range.
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Research context

OpenAlex topics: Spectroscopy Techniques in Biomedical and Chemical Research · Gold and Silver Nanoparticles Synthesis and Applications · Spectroscopy and Chemometric Analyses

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Electrical and Computer Engineering, Rice University, 6100 Main Street, Houston, Texas 77005, United States

Laboratory for Nanophotonics, Rice University, 6100 Main Street, Houston, Texas 77005, United States

Department of Materials Science and Nanoengineering, Rice University, 6100 Main Street, Houston, Texas 77005, United States

Department of Computer Science, Rice University, 6100 Main Street, Houston, Texas 77005, United States

Department of Chemistry, Rice University, 6100 Main Street, Houston, Texas 77005, United States

Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, United States

Department of Physics and Astronomy, Rice University, 6100 Main Street, Houston, Texas 77005, United States

Funding

National Institute of Environmental Health Sciences · Welch Foundation · Rice University

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