journal article·2022-06-16Open access

Resolution Limit in Infrared Chemical Imaging

Yamuna Phal, Luke Pfister, P. Scott Carney, Rohit Bhargava

The Journal of Physical Chemistry C· Volume 126· Issue 23

Abstract

Chemical imaging combines the spatial specificity of optical microscopy with the spectral selectivity of vibrational spectroscopy. Mid-infrared (IR) absorption imaging instruments are now able to capture high-quality spectra with microscopic spatial detail, but the limits of their ability to resolve spatial and spectral objects remain less understood. In particular, the sensitivity of measurements to chemical and spatial changes and rules for optical design have been presented, but the influence of spectral information on spatial sensitivity is as yet relatively unexplored. We report an information theory-based approach to quantify the spatial localization capability of spectral data in chemical imaging. We explicitly consider the joint effects of the signal-to-noise ratio and spectral separation that have significance in experimental settings to derive resolution limits in IR spectroscopic imaging.
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Research context

OpenAlex topics: Spectroscopy Techniques in Biomedical and Chemical Research · Spectroscopy and Chemometric Analyses · Thermography and Photoacoustic Techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Electrical and Computer Engineering, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States

Beckman Institute for Advanced Science and Technology, 405 N. Mathews Avenue, Urbana, Illinois 61801, United States

Dynamic Imaging & Radiography Group, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States

Institute of Optics, University of Rochester, 480 Intercampus Dr., Rochester, New York 14627, United States

Departments of Bioengineering, Chemical and Biomolecular Engineering, Mechanical Science and Engineering, and Chemistry, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States

Cancer Center at Illinois, Beckman Institute for Advanced Science and Technology, 405 N. Mathews Avenue, Urbana, Illinois 61801, United States

Funding

National Institute of Biomedical Imaging and Bioengineering

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