Thermal and Photo Dual-Responsive Core–Shell Polymeric Nanocarriers with Encapsulation of Upconversion Nanoparticles for Controlled Anticancer Drug Release

Xiaotao Wang; Chuang Liu; Zhenhua Li; Chak-Yin Tang; Wing-Cheung Law; Xinghou Gong; Zuifang Liu; Yonggui Liao; Gaowen Zhang; Shijun Long; Ling Chen

doi:10.1021/acs.jpcc.9b00454

journal article·2019-04-25Open access

Thermal and Photo Dual-Responsive Core–Shell Polymeric Nanocarriers with Encapsulation of Upconversion Nanoparticles for Controlled Anticancer Drug Release

Xiaotao Wang, Chuang Liu, Zhenhua Li, Chak-Yin Tang, Wing-Cheung Law, Xinghou Gong, Zuifang Liu, Yonggui Liao, Gaowen Zhang, Shijun Long, Ling Chen

The Journal of Physical Chemistry C· Volume 123· Issue 16

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Source abstract

Abstract

A thermal and photo dual-responsive drug delivery system is newly designed for controlled anticancer drug delivery. The concept of this design is to encapsulate upconversion nanoparticles in a photoresponsive polymer to produce core–shell nanoparticles, in which NIR light is converted to UV/visible light to isomerize cross-linked bis(methacryloylamino)-azobenzene for the control of drug release. A facile scheme, which gives the details of two-step solvothermal treatment, microemulsion, distillation precipitation polymerization, and drug loading, is proposed to realize the design. The dual-responsive drug release behaviors of the system are reported to provide the information for potential development of cancer therapy. It is also found that the Baker–Lonsdale model is suitable for describing the drug release kinetics of this system and the values of the diffusion coefficient under various conditions are determined experimentally.

Source: openalex_inverted_index · Quality: baseline

Research context

Polymers Nanomaterials

OpenAlex topics: Photochromic and Fluorescence Chemistry · Advanced Polymer Synthesis and Characterization · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Hubei Provincial Key Laboratory of Green Materials for Light Industry, Collaborative Innovation Center for Green Light-weight Materials and Processing, School of Materials Science and Engineering, Hubei University of Technology, Wuhan, Hubei Province 430068, P.R. China

Department of Industrial and Systems Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, P.R. China

Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

Funding

National Natural Science Foundation of China · Hong Kong Polytechnic University

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