Immunoreactivity and light scattering studies of polyvinyl pyrrolidone polymeric derivatives

Abstract We have studied two polymers families, one with aminoacid residues on the base of co-polymer of N-vinyl pyrrolidone and allylglycidyl ether (NVP–AGE) and another with aminoacid residues on the base of deoxidized polyvinyl pyrrolidone (Epoxy-NVP), for their possible involvement in biological procedures of the human immune system. The bioreactivity profiles of the VP–AGE and epoxidized polyvinyl pyrrolidone (EPVP) polymers and co-polymers are discussed and differences are revealed. We have performed static and dynamic light scattering measurements in the same Epoxy-NVP and NVP–AGE polymers of PVP derivatives with different amino acid-dependent groups under physiological conditions in order to uncover how the polymer structure and/or solution conformation affects immunoreactivity.