Oxidized Icariin functionalized amino-mesoporous bioactive glass with slow-release and anti-inflammatory properties potential application in bone tissue repair
Source abstract
Abstract
In order to endow bioactive glass (BG) with the anti-inflammatory activity for the purpose of promoting bone formation. In this study, Icariin (ICA) possessing excellent anti-inflammatory activity was oxidized by NaIO 4 to obtain OICA containing -CHO, and then it was loaded on aminated mesoporous bioactive glass (BG-NH 2) by Schiff base reaction to obtain BG-OICA. The results showed that compared to BG-ICA (loaded with ICA), BG-OICA-32 (loaded with OICA with oxide degree of 69.1 ± 1.5%) possessed more advantages, including higher drug loading yield (24.7 ± 0.7%, more than twice as much as that of BG-ICA), slower release rate (the cumulative release at 168 hours was less than 40%), and greater ability to BMSCs` proliferation. In addition, BG-OICA-32 exhibited improved anti-inflammatory activity compared to the carrier BG-NH 2-16 itself. Therefore, the study confirmed that OICA functionalized BG-NH 2 has great potential application in the field of bone tissue engineering.
Source: expertdata · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Medicinal Plant Pharmacodynamics Research · Silk-based biomaterials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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