Design of nanostructured siloxane-gelatin coatings: Immobilization strategies and dissolution properties
Source abstract
Abstract
Abstract Owing to the outstanding service life of metallic prostheses, a substantial effort has been put into their surface modification to improve biocompatibility and reduce metallic ion diffusion. To satisfy these requirements, the coating materials obtained using the sol-gel method, with its wide range of tuning properties, have been extensively explored. The well-known biocompatibility of these materials makes them good candidates for different biomedical applications. We designed a series of siloxane-gelatin hybrids to be used as coatings for metallic implants or in controlled delivery systems. Two different matrixes were designed based on methyltrimethoxysilane (MTMOS), tetraethoxysilane (TEOS) and 3-glycidoxypropyltrimethoxysilane (GPTMS) alkoxysilane precursors. In one hybrid coating gelatin was physically entrapped and in the other it was linked to the siloxane network by covalent bonds. Synthesis parameters were established by studying the sol-gel reaction using 29Si nuclear magnetic resonance (29Si NMR), which also allowed quantification of the network connectivity. Dissolution and degradation studies showed the effectiveness of GPTMS as a covalent coupling agent between the silica and gelatin phases; it increased the stability of the coatings in aqueous media. The aim of this study was to design a set of hybrid materials with highly tailorable properties, suitable for their potential biomedical applications.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Corrosion Behavior and Inhibition · Dental materials and restorations
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (45)
Show source-provided references
1. Recent metallic materials for biomedical applications10.1007/s11661-002-0109-2 ↗
2. Overview of metals and applications
3. Acute toxicity of metal ions in cultures of osteogenic cells derived from bone marrow stromal cells10.1002/jab.770060205 ↗
4. Potential release of in vivo trace metals from metallic medical implants in the human body: from ions to nanoparticles – a systematic analytical review10.1016/j.actbio.2014.02.027 ↗
5. Release of titanium ions from an implant surface and their effect on cytokine production related to alveolar bone resorption10.1016/j.tox.2014.10.016 ↗
6. Evaluation of titanium plasma-sprayed and plasma-sprayed hydroxyapatite implants in vivo10.1016/j.biomaterials.2003.11.053 ↗
7. Surface treatments of titanium dental implants for rapid osseointegration10.1016/j.dental.2006.06.025 ↗
8. Microstructures and bond strengths of the calcium phosphate coatings formed on titanium from different simulated body fluids10.1016/j.msec.2008.06.004 ↗
9. Basic research methods and current trends of dental implant surfaces10.1002/jbm.b.31264 ↗
10. Protection and surface modification of metals with sol–gel coatings
11. Sol-gel derived hybrid coatings as an environment friendly surface treatment for corrosion protection of meals and their alloys10.1007/s10971-012-2838-z ↗
12. Synthesis, characterization, and thermal properties of organic–inorganic hybrids based on gelatin and organomodified silicones10.1002/adv.21459 ↗
13. The influence of parameters in silica sol-gel process
14. Sol–gel coatings on metals for corrosion protection10.1016/j.porgcoat.2008.08.010 ↗
15. Sol-gel synthesis and in vitro cell compatibility analysis of silicate-containing biodegradable hybrid gels
16. Modified sol-gel coatings for biotechnological applications10.1088/1742-6596/93/1/012050 ↗
17. Development of hybrid sol–gel coatings for the improvement of metallic biomaterials performance10.1016/j.porgcoat.2016.01.019 ↗
18. Biological characterization of a new silicon based coating developed for dental implants10.1007/s10856-016-5690-9 ↗
19. Modification of collagen with a natural derived cross-linker, alginate dialdehyde10.1016/j.carbpol.2013.11.050 ↗
20. Silica-gelatin hybrids with tailorable degradation and mechanical properties for tissue regeneration10.1002/adfm.201000838 ↗
21. Covalent incorporation of non-chemically modified gelatin into degradable PVA-tyramine hydrogels10.1016/j.biomaterials.2013.06.005 ↗
22. Hydrophilic PCU scaffolds prepared by grafting PEGMA and immobilizing gelatin to enhance cell adhesion and proliferation10.1016/j.msec.2015.02.015 ↗
23. Effects of functionalized siloxane-gelatin hybrid coatings on the protein adsorption and osteogenic differentiation of hMSC
24. Enhancement of plasma protein adsorption and osteogenesis of hMSCs by functionalized siloxane coatings for titanium implants
25. Study of the degradation of hybrid sol–gel coatings in aqueous medium10.1016/j.porgcoat.2014.06.004 ↗
26. Ageing effect on the SiO2-based inorganic-organic hybrid materials10.1023/A:1011536209930 ↗
27. Composition and thermal stability of SiO2-based hybrid materials TEOS-MTEOS system10.1023/A:1022883221776 ↗
28. Linking mechanical properties of silanes to their chemical structure: an analytical study of γ-GPS solutions and films10.1016/S0300-9440(01)00135-7 ↗
29. Gelatine/silicate interactions: from nanoparticles to composite gels10.1016/j.colsurfb.2004.02.008 ↗
30. Silica–gelatin bio-hybrid and transparent nano-coatings through sol–gel technique10.1016/j.matchemphys.2007.02.068 ↗
31. Bioactive microspheres produced from gelatin–siloxane hybrids for bone regeneration10.1007/s10856-007-3332-y ↗
32. Silica–gelatin hybrids for tissue regeneration: inter-relationships between the process variables10.1007/s10971-013-3214-3 ↗
33. New synthetic route to (3-glycidoxypropyl) trimethoxysilane-based hybrid organic-inorganic materials10.1021/cm980734z ↗
34. Some effects of substrate roughness on wettability10.1007/BF02402789 ↗
35. Competitive adsorption of plasma proteins using a quartz crystal microbalance10.1021/acsami.5b12600 ↗
36. A review on the wettability of dental implant surfaces I: theoretical and experimental aspects10.1016/j.actbio.2014.02.040 ↗
37. A review on the wettability of dental implant surfaces II: biological and clinical aspects10.1016/j.actbio.2014.03.032 ↗
38. Tissue-derived cell growth on hybrid sol–gel films10.1039/B401715N ↗
39. Advancing dental implant surface technology–from micron-to nanotopography10.1016/j.biomaterials.2008.05.012 ↗
40. Cells preferentially grow on rough substrates10.1016/j.biomaterials.2010.06.016 ↗
41. Effects of fluoride-modified titanium surfaces on osteoblast proliferation and gene expression
42. Gelatin functionalization of biomaterial surfaces: strategies for immobilization and visualization10.3390/polym3010114 ↗
43. Effects of Si(IV) released from chitosan-silicate hybrids on proliferation and differentiation of MG63 osteoblast cells10.4303/bda/D110112 ↗
44. Control of the degradation of silica sol-gel hybrid coatings for metal implants prepared by the triple combination of alkoxysilanes10.1016/j.jnoncrysol.2016.09.026 ↗
45. Hydrophilic PCU scaffolds prepared by grafting PEGMA and immobilizing gelatin to enhance cell adhesion and proliferation10.1016/j.msec.2015.02.015 ↗