journal article·2025-12

Research on the photothermal-chemotherapy synergistic anti-tumor effect of a multifunctional nanoenzyme drug delivery platform

Xinyu Wang, Jingrui Chang, Xuejiao Ma, Bo Lu

Journal of Nanoparticle Research· Volume 27· Issue 12
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Abstract

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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Nanoparticle-Based Drug Delivery

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References (58)

Show source-provided references
1. Siegel RL, Miller KD, Wagle NS, Jemal A (2023) Cancer statistics, 2023. CA Cancer J Clin 73(1):17–48. https://doi.org/10.3322/caac.2176310.3322/caac.21763 ↗
2. Abreu DB, Cernadas JR (2022) Management of adverse reactions induced by chemotherapy drugs. Curr Opin Allergy Clin Immunol 22(4):221–225. https://doi.org/10.1097/ACI.000000000000083310.1097/ACI.0000000000000833 ↗
3. Kaur R, Bhardwaj A, Gupta S (2023) Cancer treatment therapies: traditional to modern approaches to combat cancers. Mol Biol Rep 50(11):9663–9676. https://doi.org/10.1007/s11033-023-08809-310.1007/s11033-023-08809-3 ↗
4. Xiang J, Zhao R, Wang B, Sun X, Guo X, Tan S, Liu W (2021) Advanced nano-carriers for anti-tumor drug loading. Front Oncol 11:758143. https://doi.org/10.3389/fonc.2021.75814310.3389/fonc.2021.758143 ↗
5. Wang C, Zhang S (2023) Advantages of nanomedicine in cancer therapy: a review. ACS Appl Nano Mater 6(24):22594–22610. https://doi.org/10.1021/acsanm.3c0448710.1021/acsanm.3c04487 ↗
6. Phan NM, Nguyen TL, Kim J (2022) Nanozyme-based enhanced cancer immunotherapy. Tissue Eng Regen Med 19(2):237–252. https://doi.org/10.1007/s13770-022-00430-y10.1007/s13770-022-00430-y ↗
7. Fu Q, Wei C, Wang M (2024) Transition-metal-based nanozymes: synthesis, mechanisms of therapeutic action, and applications in cancer treatment. ACS Nano 18(19):12049–12095. https://doi.org/10.1021/acsnano.4c0226510.1021/acsnano.4c02265 ↗
8. Zhang Y, Zhang N, Gong S-P, Chen Z-S, Cao H-L (2025) Nanozyme-based synergistic therapeutic strategies against tumors. Drug Discov Today 30(2):104292. https://doi.org/10.1016/j.drudis.2025.10429210.1016/j.drudis.2025.104292 ↗
9. Bilal M, Khaliq N, Ashraf M, Hussain N, Baqar Z, Zdarta J, Jesionowski T, Iqbal HMN (2023) Enzyme mimic nanomaterials as nanozymes with catalytic attributes. Colloids Surf B Biointerfaces 221:112950. https://doi.org/10.1016/j.colsurfb.2022.11295010.1016/j.colsurfb.2022.112950 ↗
10. Qiao Q, Liu Z, Hu F, Xu Z, Kuang Y, Li C (2025) A novel Ce─Mn heterojunction-based multi-enzymatic nanozyme with cancer-specific enzymatic activity and photothermal capacity for efficient tumor combination therapy. Adv Funct Mater 35(6):2414837. https://doi.org/10.1002/adfm.20241483710.1002/adfm.202414837 ↗
11. Xing Z, Li L, Liao T, Wang J, Guo Y, Xu Z, Yu W, Kuang Y, Li C (2024) A multifunctional cascade enzyme system for enhanced starvation/chemodynamic combination therapy against hypoxic tumors. J Colloid Interface Sci 666:244–258. https://doi.org/10.1016/j.jcis.2024.04.03610.1016/j.jcis.2024.04.036 ↗
12. Yao Y, Yang B, Shi J (2025) Crystalline copper hydroxide nanosheets with KatG-like dual activities for synergized nanocatalytic tumor therapy. Nano Lett 25(20):8369–8378. https://doi.org/10.1021/acs.nanolett.5c0165710.1021/acs.nanolett.5c01657 ↗
13. Chen G, Yan S, Ouyang C, Qiu L, Liu J, Ren L (2023) A new hydrogel to promote healing of bacteria infected wounds: enzyme-like catalytic activity based on MnO2 nanocrytal. Chem Eng J 470:143986. https://doi.org/10.1016/j.cej.2023.14398610.1016/j.cej.2023.143986 ↗
14. Greene A, Hashemi J, Kang Y (2020) Development of MnO2 hollow nanoparticles for potential drug delivery applications. Nanotechnology 32(2):025713. https://doi.org/10.1088/1361-6528/abb62610.1088/1361-6528/abb626 ↗
15. Xia H-Y, Li B-Y, Zhao Y, Han Y-H, Wang S-B, Chen A-Z, Kankala RK (2022) Nanoarchitectured manganese dioxide (MnO2)-based assemblies for biomedicine. Coord Chem Rev 464:214540. https://doi.org/10.1016/j.ccr.2022.21454010.1016/j.ccr.2022.214540 ↗
16. Sutunkova MP, Klinova SV, Ryabova YV, Tazhigulova AV, Minigalieva IA, Shabardina LV, Solovyeva SN, Bushueva TV, Privalova LI (2023) Comparative evaluation of the cytotoxic effects of metal oxide and metalloid oxide nanoparticles: an experimental study. Int J Mol Sci 24(9):8383. https://doi.org/10.3390/ijms2409838310.3390/ijms24098383 ↗
17. Soares EV, Soares HMVM (2021) Harmful effects of metal(loid) oxide nanoparticles. Appl Microbiol Biotechnol 105(4):1379–1394. https://doi.org/10.1007/s00253-021-11124-110.1007/s00253-021-11124-1 ↗
18. Yang M, He Y, Ni Q, Zhou M, Chen H, Li G, Yu J, Wu X, Zhang X (2024) Polyphenolic nanomedicine regulating mitochondria REDOX for innovative cancer treatment. Pharmaceutics 16(8):972. https://doi.org/10.3390/pharmaceutics1608097210.3390/pharmaceutics16080972 ↗
19. Wahnou H, Liagre B, Sol V, Attar HE, Attar R, Oudghiri M, Duval RE, Limami Y (2023) Polyphenol-based nanoparticles: a promising frontier for enhanced colorectal cancer treatment. Cancers 15(15):3826. https://doi.org/10.3390/cancers1515382610.3390/cancers15153826 ↗
20. Zhang Y, Hao F, Liu Y, Yang M, Zhang B, Bai Z, Zhao B, Li X (2024) Recent advances of copper-based metal phenolic networks in biomedical applications. Colloids Surf B Biointerfaces 244:114163. https://doi.org/10.1016/j.colsurfb.2024.11416310.1016/j.colsurfb.2024.114163 ↗
21. Zhou Y, Fan S, Feng L, Huang X, Chen X (2021) Manipulating intratumoral fenton chemistry for enhanced chemodynamic and chemodynamic-synergized multimodal therapy. Adv Mater 33(48):2104223. https://doi.org/10.1002/adma.20210422310.1002/adma.202104223 ↗
22. Jia C, Guo Y, Wu F-G (2021) Chemodynamic therapy via fenton and fenton-like nanomaterials: strategies and recent advances. Small 18(6):2103868. https://doi.org/10.1002/smll.20210386810.1002/smll.202103868 ↗
23. Xu X, Duan J, Liu Y, Kuang Y, Duan J, Liao T, Xu Z, Jiang B, Li C (2021) Multi-stimuli responsive hollow MnO2-based drug delivery system for magnetic resonance imaging and combined chemo-chemodynamic cancer therapy. Acta Biomater 126:445–462. https://doi.org/10.1016/j.actbio.2021.03.04810.1016/j.actbio.2021.03.048 ↗
24. Liu M, Xu Y, Zhao Y, Wang Z, Shi D (2021) Hydroxyl radical-involved cancer therapy via Fenton reactions. Front Chem Sci Eng 16(3):345–363. https://doi.org/10.1007/s11705-021-2077-310.1007/s11705-021-2077-3 ↗
25. Pucci C, Martinelli C, De Pasquale D, Battaglini M, di Leo N, Degl’Innocenti A, Belenli Gümüş M, Drago F, Ciofani G (2022) Tannic acid–iron complex-based nanoparticles as a novel tool against oxidative stress. ACS Appl Mater Interfaces 14(14):15927–15941. https://doi.org/10.1021/acsami.1c2457610.1021/acsami.1c24576 ↗
26. Youness RA, Kamel R, Elkasabgy NA, Shao P, Farag MA (2021) Recent advances in tannic acid (gallotannin) anticancer activities and drug delivery systems for efficacy improvement; a comprehensive review. Molecules 26(5):1486. https://doi.org/10.3390/molecules2605148610.3390/molecules26051486 ↗
27. He M, Du C, Xia J, Zhang Z-G, Dong C-M (2022) Multivalent polypeptide and tannic acid cooperatively iron-coordinated nanohybrids for synergistic cancer photothermal ferroptosis therapy. Biomacromolecules 23(6):2655–2666. https://doi.org/10.1021/acs.biomac.2c0040910.1021/acs.biomac.2c00409 ↗
28. Farooq MU, Lawrie CH, Deng NN (2024) Engineering nanoparticles for cancer immunotherapy: current achievements, key considerations and future perspectives. Chem Eng J 486:150356. https://doi.org/10.1016/j.cej.2024.15035610.1016/j.cej.2024.150356 ↗
29. Jiang Y, Yan C, Li M, Chen S, Chen Z, Yang L, Luo K (2024) Delivery of natural products via polysaccharide-based nanocarriers for cancer therapy: a review on recent advances and future challenges. Int J Biol Macromol 278:135072. https://doi.org/10.1016/j.ijbiomac.2024.13507210.1016/j.ijbiomac.2024.135072 ↗
30. Xiang G, Wang H, Lu C, Yu S, Wu A, Wang X (2025) Luteolin-manganese nanozyme induces apoptosis and ferroptosis for enhanced cancer therapy. Inorg Chem 64(8):3885–3897. https://doi.org/10.1021/acs.inorgchem.4c0508310.1021/acs.inorgchem.4c05083 ↗
31. Chen B, Cai L, Fan R, Mu M, Chuan D, Ren Y, Chen H, Guo G (2023) Multifunctional Ce6-loaded MnO2 as an oxygen-elevated nanoplatform for synergistic photodynamic/photothermal therapy. Materials & Design 227:111702. https://doi.org/10.1016/j.matdes.2023.11170210.1016/j.matdes.2023.111702 ↗
32. Li G, Cui M, Cai C, Zhang N, Chen S, Wang Z, Liu Q, Zhang X, Ren S, An H (2025) Application of metal polyphenol nanonetworks in phototherapy. Coord Chem Rev 539:216743. https://doi.org/10.1016/j.ccr.2025.21674310.1016/j.ccr.2025.216743 ↗
33. Yu X, Shang T, Zheng G, Yang H, Li Y, Cai Y, Xie G, Yang B (2022) Metal-polyphenol-coordinated nanomedicines for Fe(II) catalyzed photoacoustic-imaging guided mild hyperthermia-assisted ferroustherapy against breast cancer. Chin Chem Lett 33(4):1895–1900. https://doi.org/10.1016/j.cclet.2021.10.02110.1016/j.cclet.2021.10.021 ↗
34. Shen J, Chen G, Zhao L, Huang G, Liu H, Liu B, Miao Y, Li Y (2023) Recent advances in nanoplatform construction strategy for alleviating tumor hypoxia. Adv Healthc Mater 12(21):2300089. https://doi.org/10.1002/adhm.20230008910.1002/adhm.202300089 ↗
35. Hao L, Wang L, Ma Y, Bottini M, Li L, Cheng H-B, Gao S, Liang X, Zhang J (2024) Nanomaterials relieving hypoxia for enhanced tumor therapy. Coord Chem Rev 499:215482. https://doi.org/10.1016/j.ccr.2023.21548210.1016/j.ccr.2023.215482 ↗
36. Xu D, Wu L, Yao H, Zhao L (2022) Catalase-like nanozymes: classification, catalytic mechanisms, and their applications. Small 18(37):2203400. https://doi.org/10.1002/smll.20220340010.1002/smll.202203400 ↗
37. Galasso M, Gambino S, Romanelli MG, Donadelli M, Scupoli MT (2021) Browsing the oldest antioxidant enzyme: catalase and its multiple regulation in cancer. Free Radic Biol Med 172:264–272. https://doi.org/10.1016/j.freeradbiomed.2021.06.01010.1016/j.freeradbiomed.2021.06.010 ↗
38. Najafi A, Keykhaee M, Khorramdelazad H, Karimi MY, Nejatbakhsh Samimi L, Aghamohamadi N, Karimi M, Falak R, Khoobi M (2022) Catalase application in cancer therapy: simultaneous focusing on hypoxia attenuation and macrophage reprogramming. Biomed Pharmacother 153:113483. https://doi.org/10.1016/j.biopha.2022.11348310.1016/j.biopha.2022.113483 ↗
39. Qi Xuchen, Jha Kumar, S., Jha, Kumar, N., Dewanjee, Saikat, Dey, Abhijit, Deka, Rahul, Pritam, Pingal, Ramgopal, Kritika, Liu, Weiting, Hou, & Kaijian (2022) Antioxidants in brain tumors: current therapeutic significance and future prospects. Mol Cancer 21(1):204. https://doi.org/10.1186/s12943-022-01668-910.1186/s12943-022-01668-9 ↗
40. Pedro AC, Paniz OG, Fernandes IdeAA, Bortolini DG, Rubio FTV, Haminiuk CWI, Maciel GM, Magalhães WLE (2022) The importance of antioxidant biomaterials in human health and technological innovation: a review. Antioxidants 11(9):1644. https://doi.org/10.3390/antiox1109164410.3390/antiox11091644 ↗
41. Guo Z, Xie W, Lu J, Guo X, Xu J, Xu W, Chi Y, Takuya N, Wu H, Zhao L (2021) Tannic acid-based metal phenolic networks for bio-applications: a review. J Mater Chem B 9(20):4098–4110. https://doi.org/10.1039/d1tb00383f10.1039/d1tb00383f ↗
42. Yuan H, Wang F, Wang Z, Gu D, Huang W, Fu C, Wang X, Ma J, Li Z, Dai L, Zhang X, Xiao W, Wang J (2023) Natural metal polyphenol nanozyme: free radical scavenging and antioxidation for the treatment of acute kidney injury. ACS Mater Lett 5(10):2807–2819. https://doi.org/10.1021/acsmaterialslett.3c0090610.1021/acsmaterialslett.3c00906 ↗
43. Dai Q, Geng H, Yu Q, Hao J, Cui J (2019) Polyphenol-based particles for theranostics. Theranostics 9(11):3170–3190. https://doi.org/10.7150/thno.3184710.7150/thno.31847 ↗
44. Wang H, Wang C, Zou Y, Hu J, Li Y, Cheng Y (2020) Natural polyphenols in drug delivery systems: current status and future challenges. Giant 3:100022. https://doi.org/10.1016/j.giant.2020.10002210.1016/j.giant.2020.100022 ↗
45. Park Y, Jeong EM (2024) Glutathione dynamics in the tumor microenvironment: a potential target of cancer stem cells and T cells. Int J Stem Cells 17(3):270–283. https://doi.org/10.15283/ijsc2406010.15283/ijsc24060 ↗
46. Martin JD, Miyazaki T, Cabral H (2021) Remodeling tumor microenvironment with nanomedicines. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology 13(6):e1730. https://doi.org/10.1002/wnan.173010.1002/wnan.1730 ↗
47. Martins AC, Oliveira-Paula GH, Tinkov AA, Skalny AV, Tizabi Y, Bowman AB, Aschner M (2025) Role of manganese in brain health and disease: focus on oxidative stress. Free Radic Biol Med 232:306–318. https://doi.org/10.1016/j.freeradbiomed.2025.03.01310.1016/j.freeradbiomed.2025.03.013 ↗
48. Zhang W-X, Li Y, Ke D, Gao Y-R, Fei T, Wang G-Q, Shu Y, Wang J-H (2023) GSH-depleting metal–polyphenol-network nanoparticles with dual enzyme activities induce enhanced ferroptosis. Biomater Sci 11(20):6906–6918. https://doi.org/10.1039/d3bm01000g10.1039/d3bm01000g ↗
49. Liu P, Peng Y, Ding J, Zhou W (2022) Fenton metal nanomedicines for imaging-guided combinatorial chemodynamic therapy against cancer. Asian J Pharm Sci 17(2):177–192. https://doi.org/10.1016/j.ajps.2021.10.00310.1016/j.ajps.2021.10.003 ↗
50. Cao C, Wang X, Yang N, Song X, Dong X (2022) Recent advances of cancer chemodynamic therapy based on Fenton/Fenton-like chemistry. Chem Sci 13(4):863–889. https://doi.org/10.1016/j.ajps.2021.10.00310.1016/j.ajps.2021.10.003 ↗
51. Wang Z, Li Z, Shi Y, Zeng L (2023) Mesoporous polydopamine delivery system for intelligent drug release and photothermal-enhanced chemodynamic therapy using MnO2 as gatekeeper. Regen Biomater 10:rbad087. https://doi.org/10.1016/j.ajps.2021.10.00310.1016/j.ajps.2021.10.003 ↗
52. Zhang S, Li Y, Liu C, Zhang Y, Sun P, Lan X, Liu C (2022) Supramolecular amino acid-based metallo-nanozyme through multicomponent coordination self-assembly for in-site tumor synergistic catalytic-chemotherapy. Chem Eng J 437:135312. https://doi.org/10.1016/j.ajps.2021.10.00310.1016/j.ajps.2021.10.003 ↗
53. Xin J, Deng C, Aras O, Zhou M, Wu C, An F (2021) Chemodynamic nanomaterials for cancer theranostics. J Nanobiotechnology 19(1):192. https://doi.org/10.1016/j.cej.2022.135312.10.1016/j.cej.2022.135312. ↗
54. Zhang W, Wang Y, Gu M, Mao Z, Guan Y, Wang J, Mao W, Yuan W-E (2025) Manganese nanosheets loaded with selenium and gemcitabine activate the tumor microenvironment to enhance anti-tumor immunity. J Colloid Interface Sci 682:556–567. https://doi.org/10.1016/j.jcis.2024.11.22410.1016/j.jcis.2024.11.224 ↗
55. Vu GT-Q, Nguyen LM, Nguyen Do KN, Tran DL, Vo TV, Nguyen DH, Vong LB (2025) Preparation of metal–polyphenol modified zeolitic imidazolate framework-8 nanoparticles for cancer drug delivery. ACS Appl Bio Mater 8(3):2052–2064. https://doi.org/10.1021/acsabm.4c0160810.1021/acsabm.4c01608 ↗
56. Dirersa WB, Kan TC, Getachew G, Wibrianto A, Ochirbat S, Rasal A, Chang Jungshan, Chang JY (2023) Preclinical assessment of enhanced chemodynamic therapy by an FeMnO x-based nanocarrier: tumor-microenvironment-mediated Fenton Reaction and ROS-induced chemotherapeutic for boosted antitumor activity. ACS Appl Mater Interfaces 15(48):55258–55275. https://doi.org/10.1021/acsami.3c1073310.1021/acsami.3c10733 ↗
57. Dirersa WB, Kan TC, Chang J, Getachew G, Ochirbat S, Kizhepat S, Wibrianto Aswandi, Rasal Akash, Chen Hung-An, Ghule Anil Vithal, Chou Tzung-Han, Chang JY (2024) Engineering H2O2 self-supplying platform for xdynamic therapies via Ru–Cu peroxide nanocarrier: tumor microenvironment-mediated synergistic therapy. ACS Appl Mater Interfaces 16(19):24172–24190. https://doi.org/10.1021/acsami.3c1888810.1021/acsami.3c18888 ↗
58. Dirersa WB, Getachew G, Hsiao CH, Wibrianto A, Rasal AS, Huang CC, Chang JY (2022) Surface-engineered CuFeS2/Camptothecin nanoassembly with enhanced chemodynamic therapy via GSH depletion for synergistic photo/chemotherapy of cancer. Mater Today Chem 26:101158. https://doi.org/10.1016/j.mtchem.2022.10115810.1016/j.mtchem.2022.101158 ↗