Zinc ion-coordinated high-drug-loading nanoparticles for enhanced anti-tumor therapy
Bibliographic record
Abstract
No abstract is available for this record. The assistant can identify its topic from the title, but cannot infer the study’s results.
Source: Not provided · Quality: missing
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (45)
Show source-provided references
1. Yan M, Wu S, Wang Y, Liang M, Wang M, Hu W, Yu G, Mao Z, Huang F, Zhou J (2024) Recent progress of supramolecular chemotherapy based on host-guest interactions. Adv Mater 36(21):e2304249. https://doi.org/10.1002/adma.20230424910.1002/adma.202304249 ↗
2. Wei G, Wang Y, Yang G, Wang Y, Ju R (2021) Recent progress in nanomedicine for enhanced cancer chemotherapy. Theranostics 11(13):6370–6392. https://doi.org/10.7150/thno.5782810.7150/thno.57828 ↗
3. Tao L, Zhou Y, Luo Y, Qiu J, Xiao Y, Zou J, Zhang Y, Liu X, Yang X, Gou K, Xu J, Guan X, Cen X, Zhao Y (2024) Epigenetic regulation in cancer therapy: from mechanisms to clinical advances. MedComm – Oncology. https://doi.org/10.1002/mog2.5910.1002/mog2.59 ↗
4. Yang L, Yao C, Su Z, Fang Y, Pandey NK, Amador E, Diao T, Bao G, Cao D, Chen X, Xu X, He B, Zheng Y, Chen W (2024) Combination of disulfiram and Copper-Cysteamine nanoparticles induces mitochondria damage and promotes apoptosis in endometrial cancer. Bioact Mater 36:96–111. https://doi.org/10.1016/j.bioactmat.2024.02.00910.1016/j.bioactmat.2024.02.009 ↗
5. Yuan M, Shi L, Liu Y, Xiang K, Zhang Y, Zhou Y, Wang J, Ji M, Hou P (2025) Disulfiram/copper triggers cGAS-STING innate immunity pathway via ROS-induced DNA damage that potentiates antitumor response to PD-1 checkpoint blockade. Int J Biol Sci 21(4):1730–1748. https://doi.org/10.7150/ijbs.10557510.7150/ijbs.105575 ↗
6. Cui J, Li W, Bu W, Liu J, Chen X, Li X, Liu C, Meng L, Chen M, Sun H, Wang J (2022) Folic acid-modified disulfiram/Zn-IRMOF3 nanoparticles for oral cancer therapy by inhibiting ALDH1A1+ cancer stem cells. Biomater Adv 139:213038. https://doi.org/10.1016/j.bioadv.2022.21303810.1016/j.bioadv.2022.213038 ↗
7. Yang Y, Zhu Y, Wang K, Miao Y, Zhang Y, Gao J, Qin H, Zhang Y (2023) Activation of autophagy by in situ Zn(2+) chelation reaction for enhanced tumor chemoimmunotherapy. Bioact Mater 29:116–131. https://doi.org/10.1016/j.bioactmat.2023.06.02210.1016/j.bioactmat.2023.06.022 ↗
8. Lu Y, Pan Q, Gao W, Pu Y, Luo K, He B, Gu Z (2022) Leveraging disulfiram to treat cancer: mechanisms of action, delivery strategies, and treatment regimens. Biomaterials 281:121335. https://doi.org/10.1016/j.biomaterials.2021.12133510.1016/j.biomaterials.2021.121335 ↗
9. Zhao Y-Z, Lin M-T, Lan Q-H, Zhai Y-Y, Xu H-L, Xiao J, Kou L, Yao Q (2020) Silk fibroin-modified disulfiram/zinc oxide nanocomposites for pH triggered release of Zn2+ and synergistic antitumor efficacy. Mol Pharm 17(10):3857–3869. https://doi.org/10.1021/acs.molpharmaceut.0c0060410.1021/acs.molpharmaceut.0c00604 ↗
10. Tang Y, Dang M, Li Y, Sha X, Xu Z, Zhang J, Wu F, Wang S (2025) In situ activatable disulfiram-rhodium(III) nanocomplex for Cu chelation and STAT3 inhibition to potentiate photodynamic and immunotherapy. Chem Eng J. https://doi.org/10.1016/j.cej.2025.16018210.1016/j.cej.2025.160182 ↗
11. Feng Y, Chen H, Chen S, Zhang K, Yun D, Liu D, Zeng J, Yang C, Xie Q (2025) Disulfiram-loaded PLGA nanoparticles modified with a phenyl borate chitosan conjugate enhance hepatic carcinoma treatment. Int J Pharm 671:125293. https://doi.org/10.1016/j.ijpharm.2025.12529310.1016/j.ijpharm.2025.125293 ↗
12. Wang Y, Zhou Q, Luo W, Yang X, Zhang J, Lou Y, Mao J, Chen J, Wu F, Hou J, Tang G, Bai H, Yu R (2024) A collagenase-decorated Cu-based nanotheranostics: remodeling extracellular matrix for optimizing cuproptosis and MRI in pancreatic ductal adenocarcinoma. J Nanobiotechnology 22(1):689. https://doi.org/10.1186/s12951-024-02968-610.1186/s12951-024-02968-6 ↗
13. Guo Z, Gao X, Lu J, Li Y, Jin Z, Fahad A, Pambe NU, Ejima H, Sun X, Wang X, Xie W, Zhang G, Zhao L (2024) Apoptosis and paraptosis induced by disulfiram-loaded Ca2+/Cu2+ dual-ions nano trap for breast cancer treatment. ACS Nano 18(9):6975–6989. https://doi.org/10.1021/acsnano.3c1017310.1021/acsnano.3c10173 ↗
14. Xu L, Chen Q, Qian Y, Wang J, Wang C, Fan R, Shen J-W, Shen Q (2025) NIR-activatable proenzyme DSF/CuS@M for synergistic in situ chemotherapy/CDT/PTT/cuproptosis-based antitumor therapy. Chem Eng J. https://doi.org/10.1016/j.cej.2025.16173310.1016/j.cej.2025.161733 ↗
15. Zhao L, Wang X, Lou H, Jiang M, Wu X, Qin J, Zhang J, Guan X, Li W, Zhang W, Ma J (2022) Buffet-style Cu(II) for enhance disulfiram-based cancer therapy. J Colloid Interface Sci 624:734–746. https://doi.org/10.1016/j.jcis.2022.06.00910.1016/j.jcis.2022.06.009 ↗
16. Tang H-X, Zhang J-T, Liu C-G, Wang S-B, Zheng X-K, Chen A-Z (2023) An ultra-high disulfiram-loaded delivery system achieved by supercritical carbon dioxide technology for copper-enhanced chemotherapy. J CO2 Util. https://doi.org/10.1016/j.jcou.2023.10242610.1016/j.jcou.2023.102426 ↗
17. Li Q, Chao Y, Liu B, Xiao Z, Yang Z, Wu Y, Liu Z (2022) Disulfiram loaded calcium phosphate nanoparticles for enhanced cancer immunotherapy. Biomaterials 291:121880. https://doi.org/10.1016/j.biomaterials.2022.12188010.1016/j.biomaterials.2022.121880 ↗
18. Sun Z, Wei S, Guo Q, Ouyang H, Mao Z, Wang W, Tong Z, Ding Y (2025) V9302-loaded copper-polyphenol hydrogel for enhancing the anti-tumor effect of disulfiram. J Colloid Interface Sci 678(Pt B):866–877. https://doi.org/10.1016/j.jcis.2024.08.24010.1016/j.jcis.2024.08.240 ↗
19. Liang X, Li C, Yuan W, Ji M, Zhang J, Yan M, Lu Q, Gou J, Yin T, He H, Tang X, Zhang Y (2024) Activate the endogenous Cu(2+) switch for Zn(DDC)(2) liposomes conversion: providing a safer and less toxic alternative in cancer therapy. Int J Pharm 652:123800. https://doi.org/10.1016/j.ijpharm.2024.12380010.1016/j.ijpharm.2024.123800 ↗
20. Tang H-X, Liu C-G, Zhang J-T, Zheng X, Yang D-Y, Kankala RK, Wang S-B, Chen A-Z (2020) Biodegradable quantum composites for synergistic photothermal therapy and copper-enhanced chemotherapy. ACS Appl Mater Interfaces 12(42):47289–47298. https://doi.org/10.1021/acsami.0c1463610.1021/acsami.0c14636 ↗
21. Wang Y, Gao F, Zhao L, Wu Y, Li C, Li H, Jiang Y (2024) Enhancing cancer treatment via “Zn2+ interference” with Zn-based nanomaterials. Coord Chem Rev. https://doi.org/10.1016/j.ccr.2023.21553510.1016/j.ccr.2023.215535 ↗
22. Yang Y, Fan H, Xu X, Yao S, Yu W, Guo Z (2024) Zinc ion-induced immune responses in antitumor immunotherapy. CCS Chem 6(9):2210–2229. https://doi.org/10.31635/ccschem.023.20230351410.31635/ccschem.023.202303514 ↗
23. Narayan S, Dalal R, Rizvi ZA, Awasthi A (2024) Zinc dampens antitumor immunity by promoting Foxp3(+) regulatory T cells. Front Immunol 15:1389387. https://doi.org/10.3389/fimmu.2024.138938710.3389/fimmu.2024.1389387 ↗
24. Liu M, Peng Y, Nie Y, Liu P, Hu S, Ding J, Zhou W (2020) Co-delivery of doxorubicin and DNAzyme using ZnO@polydopamine core-shell nanocomposites for chemo/gene/photothermal therapy. Acta Biomater 110:242–253. https://doi.org/10.1016/j.actbio.2020.04.04110.1016/j.actbio.2020.04.041 ↗
25. Qiu L, Ouyang C, Zhang W, Liu J, Yu L, Chen G, Ren L (2023) Zn-MOF hydrogel: regulation of ROS-mediated inflammatory microenvironment for treatment of atopic dermatitis. J Nanobiotechnol 21(1):163. https://doi.org/10.1186/s12951-023-01924-010.1186/s12951-023-01924-0 ↗
26. Anson KJ, Corbet GA, Palmer AE (2021) Zn(2+) influx activates ERK and Akt signaling pathways. Proc Natl Acad Sci U S A. https://doi.org/10.1073/pnas.201578611810.1073/pnas.2015786118 ↗
27. Dalla Pozza E, Donadelli M, Costanzo C, Zaniboni T, Dando I, Franchini M, Arpicco S, Scarpa A, Palmieri M (2011) Gemcitabine response in pancreatic adenocarcinoma cells is synergistically enhanced by dithiocarbamate derivatives. Free Radic Biol Med 50(8):926–933. https://doi.org/10.1016/j.freeradbiomed.2011.01.00110.1016/j.freeradbiomed.2011.01.001 ↗
28. Zeng C, Jiang X, Ji M, Chu C, Liu B, Yin T, Tang X, Gou J, He H, Zhang Y (2025) pH-responsive ZIF-8 nanoplatform co-loaded with DSF and ICG for multiple synergistic antitumor therapy. Int J Pharm 672:125343. https://doi.org/10.1016/j.ijpharm.2025.12534310.1016/j.ijpharm.2025.125343 ↗
29. Mohankumar M, Fernandes S, Cavalieri F, Cortez-Jugo C, Caruso F (2025) Ultrasound-driven coassembly of anticancer drugs into carrier-free particles. ACS Nano 19(13):13366–13380. https://doi.org/10.1021/acsnano.5c0128410.1021/acsnano.5c01284 ↗
30. Ma B, Ma Y, Deng B, Xiao P, Huang P, Wang D, Liu L (2023) Tumor microenvironment-responsive spherical nucleic acid nanoparticles for enhanced chemo-immunotherapy. J Nanobiotechnology 21(1):171. https://doi.org/10.1186/s12951-023-01916-010.1186/s12951-023-01916-0 ↗
31. Xiang X, Pang H, Ma T, Du F, Li L, Huang J, Ma L, Qiu L (2021) Ultrasound targeted microbubble destruction combined with Fe-MOF based bio-/enzyme-mimics nanoparticles for treating of cancer. J Nanobiotechnology 19(1):92. https://doi.org/10.1186/s12951-021-00835-210.1186/s12951-021-00835-2 ↗
32. Liu X, Liu S, Jin X, Liu H, Sun K, Wang X, Li M, Wang P, Chang Y, Wang T, Wang B, Yu XA (2024) An encounter between metal ions and natural products: natural products-coordinated metal ions for the diagnosis and treatment of tumors. J Nanobiotechnol 22(1):726. https://doi.org/10.1186/s12951-024-02981-910.1186/s12951-024-02981-9 ↗
33. Chen Q, Fang C, Xia F, Wang Q, Li F, Ling D (2024) Metal nanoparticles for cancer therapy: precision targeting of DNA damage. Acta Pharm Sin B 14(3):1132–1149. https://doi.org/10.1016/j.apsb.2023.08.03110.1016/j.apsb.2023.08.031 ↗
34. Wang L, Lin D, Li M, Jiang Y, Yang Y, Wang H, Chu H, Ye J, Liu Y (2025) Bioactive metallic nanoparticles for synergistic cancer immunotherapy. Acta Pharm Sin B 15(4):1869–1911. https://doi.org/10.1016/j.apsb.2025.02.02210.1016/j.apsb.2025.02.022 ↗
35. Chen W, Yang W, Chen P, Huang Y, Li F (2018) Disulfiram copper nanoparticles prepared with a stabilized metal ion ligand complex method for treating drug-resistant prostate cancers. ACS Appl Mater Interfaces 10(48):41118–41128. https://doi.org/10.1021/acsami.8b1494010.1021/acsami.8b14940 ↗
36. Wei H, Jiang D, Yu B, Ni D, Li M, Long Y, Ellison PA, Siamof CM, Cheng L, Barnhart TE, Im HJ, Yu F, Lan X, Zhu X, He Q, Cai W (2023) Nanostructured polyvinylpyrrolidone-curcumin conjugates allowed for kidney-targeted treatment of cisplatin induced acute kidney injury. Bioact Mater 19:282–291. https://doi.org/10.1016/j.bioactmat.2022.04.00610.1016/j.bioactmat.2022.04.006 ↗
37. Dong Y, Wang H, Zhang Y, Wu Y, Lu L, Yu H, Zhou L, Zhao P, Ouyang S, Song Z, Hu Z, Lv D, Rong Y, Zhao Z, Tao J, Tang B, Luo S (2024) Nir-ii light based combinatorial management of hypertrophic scar by inducing autophagy in fibroblasts. J Nanobiotechnology 22(1):625. https://doi.org/10.1186/s12951-024-02876-910.1186/s12951-024-02876-9 ↗
38. Yang Y, Wang T, Xiao M, Hou Z, Liu Y, Zhang K, Yang L, Sun S (2025) Polysaccharides as submucosal injection materials (SIMs) in endoscopic resection: a comprehensive review. Carbohydr Polym 355:123360. https://doi.org/10.1016/j.carbpol.2025.12336010.1016/j.carbpol.2025.123360 ↗
39. Hou J, Zhao Y, Sun L, Zou X (2023) Enzyme/GSH/pH-responsive hyaluronic acid grafted porous silica nanocarriers bearing Ag(2)S QDs for fluorescence imaging and combined therapy. Carbohydr Polym 305:120547. https://doi.org/10.1016/j.carbpol.2023.12054710.1016/j.carbpol.2023.120547 ↗
40. Liu B, Bian Y, Yuan M, Zhu Y, Liu S, Ding H, Gai S, Yang P, Cheng Z, Lin J (2022) L-buthionine sulfoximine encapsulated hollow calcium peroxide as a chloroperoxidase nanocarrier for enhanced enzyme dynamic therapy. Biomaterials 289:121746. https://doi.org/10.1016/j.biomaterials.2022.12174610.1016/j.biomaterials.2022.121746 ↗
41. He Z-H, Tang H-X, Pan Y-Z, Cen M, Zhang Z-J (2024) Glutathione-responsive nanoplatforms based on coordination between Fe3+ and apigenin for synergistic chemo/chemodynamic therapy. ACS Appl Nano Mater 7(24):28380–28392. https://doi.org/10.1021/acsanm.4c0548610.1021/acsanm.4c05486 ↗
42. Zhang L, Zhao J, Hu X, Wang C, Jia Y, Zhu C, Xie S, Lee J, Li F, Ling D (2022) A peritumorally injected immunomodulating adjuvant elicits robust and safe metalloimmunotherapy against solid tumors. Adv Mater 34(41):e2206915. https://doi.org/10.1002/adma.20220691510.1002/adma.202206915 ↗
43. Xu Z, Zhang S, Zhang X, He Y, Zhang J, Yuan M, Liu C, Liu H, Gao D, Wang D (2025) Cyclized polyacrylonitrile nanoparticles: enhanced intratumoral delivery by photocatalysis and collagen denaturation. J Colloid Interface Sci. https://doi.org/10.1016/j.jcis.2025.13782910.1016/j.jcis.2025.137829 ↗
44. Huang Y, Tian H, Yue Z, liang L, Huang C, Zhu H, Yang J (2025) Copper-coordination driven nano-frameworks for efficient colorectal cancer chemo-immunotherapy by suppression of cancer cell stemness. Mater Today Bio. https://doi.org/10.1016/j.mtbio.2025.10170710.1016/j.mtbio.2025.101707 ↗
45. Wang T, Zhang F, Guimarães CF, Reis RL, Lv Y, Qu Y, Liu D, Zhou Q, Kong X, Shi J (2024) Zn/Cu bi-single-atom nanoplatform: hexagonal anti-tumor warrior by ROS amplification for DOX resistance reversal and immune activation. Adv Funct Mater. https://doi.org/10.1002/adfm.20241096210.1002/adfm.202410962 ↗